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The map label for this gene is cidA1

Identifier: 49186461

GI number: 49186461

Start: 3432919

End: 3433284

Strand: Direct

Name: cidA1

Synonym: BAS3458

Alternate gene names: 49186461

Gene position: 3432919-3433284 (Clockwise)

Preceding gene: 49186456

Following gene: 49186462

Centisome position: 65.66

GC content: 33.88

Gene sequence:

>366_bases
ATGAAATGGTGGAAATTAAGCGGACAAATTTTACTATTATTTTGTTTCGCTTGGACAGGTGAATGGATTGCAAAACAGGC
ACACCTCCCAATTCCAGGAAGTATTATCGGTATTTTTTTATTATTAATTTCATTAAAATTTAACCTAGTGAAAAAAGAGT
GGATACAGGATGGTGCAGACTTTTTATTAAAAGAACTTATTTTATTTTTCATTCCTTCTGCAGTCGCTGTCATACGCTAC
AAAGATACACTATCACAATATGGAATCGATCTCATCTTAATTATTATGATTAGTACACTTTGTGTCACTCTCGTTACAGG
ACTCTTAACAGAATTGCTACTAAAGCGGAAAGGATCCGTGCAATGA

Upstream 100 bases:

>100_bases
TAATTTATATATTAGACAAATTTTTCGAATGAACGTATAGTAGAAATTGTTAATTCTTTTTTACAATTTTTATGTAAAAA
AAGAAAGAGGTGGTTACTGT

Downstream 100 bases:

>100_bases
TCGGCTTTCTTTGTTTACTATTAACACTATTCACATATTGGATATCGAAGAAAATGTATCAACGCTGGAATTGGAGCCTA
CTTTCTCCTCTTCTCGTCTG

Product: holin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MKWWKLSGQILLLFCFAWTGEWIAKQAHLPIPGSIIGIFLLLISLKFNLVKKEWIQDGADFLLKELILFFIPSAVAVIRY
KDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSVQ

Sequences:

>Translated_121_residues
MKWWKLSGQILLLFCFAWTGEWIAKQAHLPIPGSIIGIFLLLISLKFNLVKKEWIQDGADFLLKELILFFIPSAVAVIRY
KDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSVQ
>Mature_121_residues
MKWWKLSGQILLLFCFAWTGEWIAKQAHLPIPGSIIGIFLLLISLKFNLVKKEWIQDGADFLLKELILFFIPSAVAVIRY
KDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSVQ

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CIDA1_BACAN (Q81Y27)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_845993.1
- RefSeq:   YP_020367.1
- RefSeq:   YP_029713.1
- EnsemblBacteria:   EBBACT00000012181
- EnsemblBacteria:   EBBACT00000018191
- EnsemblBacteria:   EBBACT00000022070
- GeneID:   1086808
- GeneID:   2818311
- GeneID:   2849077
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3730
- KEGG:   bar:GBAA_3730
- KEGG:   bat:BAS3458
- TIGR:   BA_3730
- TIGR:   GBAA_3730
- GeneTree:   EBGT00050000000864
- HOGENOM:   HBG697118
- OMA:   GDLLLFF
- ProtClustDB:   PRK01658
- BioCyc:   BANT260799:BAS3458-MONOMER
- BioCyc:   BANT261594:GBAA3730-MONOMER
- GO:   GO:0019835
- HAMAP:   MF_01143
- InterPro:   IPR005538

Pfam domain/function: PF03788 LrgA

EC number: NA

Molecular weight: Translated: 13749; Mature: 13749

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14b613e8)-; HASH(0x153a8a88)-; HASH(0x153c2dfc)-; HASH(0x15002918)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWWKLSGQILLLFCFAWTGEWIAKQAHLPIPGSIIGIFLLLISLKFNLVKKEWIQDGAD
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLKELILFFIPSAVAVIRYKDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Q
H
>Mature Secondary Structure
MKWWKLSGQILLLFCFAWTGEWIAKQAHLPIPGSIIGIFLLLISLKFNLVKKEWIQDGAD
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLKELILFFIPSAVAVIRYKDTLSQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Q
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629