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The map label for this gene is qor [C]

Identifier: 49186265

GI number: 49186265

Start: 3227117

End: 3227689

Strand: Direct

Name: qor [C]

Synonym: BAS3260

Alternate gene names: 49186265

Gene position: 3227117-3227689 (Clockwise)

Preceding gene: 49186263

Following gene: 49186266

Centisome position: 61.72

GC content: 36.3

Gene sequence:

>573_bases
ATGAAAGCAATTGGTTTACATGAATATTTACCTATTGAAGAAGAAAACAGTTTAATTGATATGGAAATTGAAAGACCTGT
TGCTACAGGAAGAGATATACTCGTTAAAATTAACGCTATTTCCGTTAATCCAGTTGATACAAAAGTTCGCTCTCCGAAAG
ATAAAAAAGAAGAAGTAGCGAAAATACTTGGCTGGGATGCGAGTGGTGTTGTTGTACAAACCGGCGAAAGTTGTACGTTA
TTTAAAGAAGGCGATGAAGTGTTTTACGCTGGAAGCATTACGAAACAAGGTACATATAGTGAATACCACCTAGTTGATGA
AAGAATTGTTGGTAAAAAACCAAAAACGTTAAGTAATGCTGAATCAGCAGCACTTCCGTTAACAGCTATTACAGCTTGGG
AAGGTTTATTTGAACGTTTAGGTATTGATTATAATAAGAAAGATACGAACTCCTTTAAAAACATTTTAATTATAGGCGGT
GCTGGTGGTGTAGGTTCAATTGCCATTCAACTTGCGAAATGGGCTGGACTAAATGTTATCACAACTGCATCCCGCAATGA
AACGATACACTAG

Upstream 100 bases:

>100_bases
GTACAGCTTACATAAAAAAGAGGGTATTTTTTTACATAGCAGTATTTCACCATCTATAATATAGAAGTAAAGGATTCTTA
CTTTAATGGAGGGAATACAA

Downstream 100 bases:

>100_bases
GTTGAAAAATTTGGTGCCGATTATATTATTAACCATCACCAACCTTTACAAGATCAAATATTAGAATTCGGGATAAAAGA
TGTAGATTATATTTTTTGCT

Product: zinc-binding dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKAIGLHEYLPIEEENSLIDMEIERPVATGRDILVKINAISVNPVDTKVRSPKDKKEEVAKILGWDASGVVVQTGESCTL
FKEGDEVFYAGSITKQGTYSEYHLVDERIVGKKPKTLSNAESAALPLTAITAWEGLFERLGIDYNKKDTNSFKNILIIGG
AGGVGSIAIQLAKWAGLNVITTASRNETIH

Sequences:

>Translated_190_residues
MKAIGLHEYLPIEEENSLIDMEIERPVATGRDILVKINAISVNPVDTKVRSPKDKKEEVAKILGWDASGVVVQTGESCTL
FKEGDEVFYAGSITKQGTYSEYHLVDERIVGKKPKTLSNAESAALPLTAITAWEGLFERLGIDYNKKDTNSFKNILIIGG
AGGVGSIAIQLAKWAGLNVITTASRNETIH
>Mature_190_residues
MKAIGLHEYLPIEEENSLIDMEIERPVATGRDILVKINAISVNPVDTKVRSPKDKKEEVAKILGWDASGVVVQTGESCTL
FKEGDEVFYAGSITKQGTYSEYHLVDERIVGKKPKTLSNAESAALPLTAITAWEGLFERLGIDYNKKDTNSFKNILIIGG
AGGVGSIAIQLAKWAGLNVITTASRNETIH

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=172, Percent_Identity=37.7906976744186, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI194239676, Length=167, Percent_Identity=31.7365269461078, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI194239674, Length=167, Percent_Identity=31.7365269461078, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI13236495, Length=167, Percent_Identity=31.7365269461078, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=169, Percent_Identity=32.5443786982249, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=170, Percent_Identity=31.1764705882353, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 20673; Mature: 20673

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGLHEYLPIEEENSLIDMEIERPVATGRDILVKINAISVNPVDTKVRSPKDKKEEVA
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHH
KILGWDASGVVVQTGESCTLFKEGDEVFYAGSITKQGTYSEYHLVDERIVGKKPKTLSNA
HHHCCCCCCEEEECCCCEEEEECCCEEEEECCCCCCCCCCHHEEHHHHHCCCCCCCCCCC
ESAALPLTAITAWEGLFERLGIDYNKKDTNSFKNILIIGGAGGVGSIAIQLAKWAGLNVI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHEEHHHHCCCEEE
TTASRNETIH
EECCCCCCCC
>Mature Secondary Structure
MKAIGLHEYLPIEEENSLIDMEIERPVATGRDILVKINAISVNPVDTKVRSPKDKKEEVA
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHH
KILGWDASGVVVQTGESCTLFKEGDEVFYAGSITKQGTYSEYHLVDERIVGKKPKTLSNA
HHHCCCCCCEEEECCCCEEEEECCCEEEEECCCCCCCCCCHHEEHHHHHCCCCCCCCCCC
ESAALPLTAITAWEGLFERLGIDYNKKDTNSFKNILIIGGAGGVGSIAIQLAKWAGLNVI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHEEHHHHCCCEEE
TTASRNETIH
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA