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The map label for this gene is pbp [H]

Identifier: 49186256

GI number: 49186256

Start: 3220557

End: 3221681

Strand: Direct

Name: pbp [H]

Synonym: BAS3251

Alternate gene names: 49186256

Gene position: 3220557-3221681 (Clockwise)

Preceding gene: 49186255

Following gene: 49186261

Centisome position: 61.59

GC content: 34.76

Gene sequence:

>1125_bases
ATGAAGTTTTTCTTTTTCTCTCATTCTCTCTATTTACTACTGTATAATAGAACTAACATTCTGTCTTTTTTGAAGAAAGG
AGTCACTATGAAATTAAAAAGTAACAATATATACGAAAAAATGAACCAATATTCTGTTGTAGGTTTAAGTCTTGCTGTTA
TACGCGACGGCAAACTAGATGAAACAGCTGCTTTCGGAACGCTTGAATCCGGAACTAATAGAACTGTCACTATAGATTCC
ATATTCAATTCTTGTTCTATTAGTAAATTTATCACCACAATTCTCATACTAACATTATCCGATCTCAAAATCGTACATTT
AGACGAAGACGTTAATGATAGACTCACATCTTGGAACATCCCTACTAATCTATTTACTTCACAGAAAAAAGTCACATTGC
GAAACTTGTTAAGTCACCAATCTGGAATCATTGATCCTCCTAATAGCTTTGAACATTATCTACTTGCACAAGGGCAACCA
AACATGTCTGAACTCCTTGCCGGTAAAACATTATATTGCTCCGTACCTATTGAAGTAACTTATAAACCAGAAAGCGAATT
TCACTACTCGGATGCAAACTTTTGTATAATCGAAATACTACTTGAAGATATAACTGGAAAGCCATTCAACCTTTTACTAG
AAGAATCTATATTTCAACCACTGCAAATGAAGAATAGTACAATCTTCTCTCCTGAAGACATAGATAAAACCGATGCTTTT
GCTTGCGGACATAATAAAGATGGCACCGTTACAAATGAGAAGTATCCATTTTATCCATTCGCAGCTGCTTCAGGTATTTG
GACAACACCAACTGACTTATCAGCTTTAGTTATTGAAATCATTCATTCCTTACAAGGAAAAGGCAAACTAAAACTTTCTC
AAAAAACAGTACAAGATATGATTTCTCCTCAAGGTTGCTCAAAATGGACTGGCTTAGGTGTTTTTCTAGATGATTTGAAT
GAAGACTTACAAATTTATTCACTCGGATGGGGCGTTGGATTTCAATGTATGATGATATGCTATCCATACCGAGGTAATGG
CGCTATTATAATGACGAACGCTGACTTAGGTGTTCATCAAATGGAAGGGATTATTGGTGACGTTTTAAAAACGTTATCGT
TATAA

Upstream 100 bases:

>100_bases
TTATTTCCTTTATTACAGCCTCATGGCTTATGTACATATACCGCGATAAATTTTTTAAAGCATTCACTTCGAATTAACTA
AAAAACTTCATCTTTAATCG

Downstream 100 bases:

>100_bases
TGAAAAAGAAAGAAGCTGTTCCTTTCAGCTTCTTTCTTATATAACATTTTTCGCAACAATTTTTATATGTTCTGGTGCGA
TAATCTCCGTTATACTTTCT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKFFFFSHSLYLLLYNRTNILSFLKKGVTMKLKSNNIYEKMNQYSVVGLSLAVIRDGKLDETAAFGTLESGTNRTVTIDS
IFNSCSISKFITTILILTLSDLKIVHLDEDVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYLLAQGQP
NMSELLAGKTLYCSVPIEVTYKPESEFHYSDANFCIIEILLEDITGKPFNLLLEESIFQPLQMKNSTIFSPEDIDKTDAF
ACGHNKDGTVTNEKYPFYPFAAASGIWTTPTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDLN
EDLQIYSLGWGVGFQCMMICYPYRGNGAIIMTNADLGVHQMEGIIGDVLKTLSL

Sequences:

>Translated_374_residues
MKFFFFSHSLYLLLYNRTNILSFLKKGVTMKLKSNNIYEKMNQYSVVGLSLAVIRDGKLDETAAFGTLESGTNRTVTIDS
IFNSCSISKFITTILILTLSDLKIVHLDEDVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYLLAQGQP
NMSELLAGKTLYCSVPIEVTYKPESEFHYSDANFCIIEILLEDITGKPFNLLLEESIFQPLQMKNSTIFSPEDIDKTDAF
ACGHNKDGTVTNEKYPFYPFAAASGIWTTPTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDLN
EDLQIYSLGWGVGFQCMMICYPYRGNGAIIMTNADLGVHQMEGIIGDVLKTLSL
>Mature_374_residues
MKFFFFSHSLYLLLYNRTNILSFLKKGVTMKLKSNNIYEKMNQYSVVGLSLAVIRDGKLDETAAFGTLESGTNRTVTIDS
IFNSCSISKFITTILILTLSDLKIVHLDEDVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYLLAQGQP
NMSELLAGKTLYCSVPIEVTYKPESEFHYSDANFCIIEILLEDITGKPFNLLLEESIFQPLQMKNSTIFSPEDIDKTDAF
ACGHNKDGTVTNEKYPFYPFAAASGIWTTPTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDLN
EDLQIYSLGWGVGFQCMMICYPYRGNGAIIMTNADLGVHQMEGIIGDVLKTLSL

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI115533026, Length=354, Percent_Identity=27.4011299435028, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 41814; Mature: 41814

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFFFSHSLYLLLYNRTNILSFLKKGVTMKLKSNNIYEKMNQYSVVGLSLAVIRDGKLD
CEEEEEECEEEEEEECCHHHHHHHHCCCEEEEECCCHHHHHCCEEEEEEEEEEEECCCCC
ETAAFGTLESGTNRTVTIDSIFNSCSISKFITTILILTLSDLKIVHLDEDVNDRLTSWNI
CHHHCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCEECCC
PTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYLLAQGQPNMSELLAGKTLYCSVPIEVT
CCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHCCCEEEEEEEEEEE
YKPESEFHYSDANFCIIEILLEDITGKPFNLLLEESIFQPLQMKNSTIFSPEDIDKTDAF
ECCCCCEEECCCCHHHEEEHHHHHCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCE
ACGHNKDGTVTNEKYPFYPFAAASGIWTTPTDLSALVIEIIHSLQGKGKLKLSQKTVQDM
ECCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
ISPQGCSKWTGLGVFLDDLNEDLQIYSLGWGVGFQCMMICYPYRGNGAIIMTNADLGVHQ
CCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEEEEECCCEEEEEECCCCHHH
MEGIIGDVLKTLSL
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKFFFFSHSLYLLLYNRTNILSFLKKGVTMKLKSNNIYEKMNQYSVVGLSLAVIRDGKLD
CEEEEEECEEEEEEECCHHHHHHHHCCCEEEEECCCHHHHHCCEEEEEEEEEEEECCCCC
ETAAFGTLESGTNRTVTIDSIFNSCSISKFITTILILTLSDLKIVHLDEDVNDRLTSWNI
CHHHCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCEECCC
PTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYLLAQGQPNMSELLAGKTLYCSVPIEVT
CCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHCCCEEEEEEEEEEE
YKPESEFHYSDANFCIIEILLEDITGKPFNLLLEESIFQPLQMKNSTIFSPEDIDKTDAF
ECCCCCEEECCCCHHHEEEHHHHHCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCE
ACGHNKDGTVTNEKYPFYPFAAASGIWTTPTDLSALVIEIIHSLQGKGKLKLSQKTVQDM
ECCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
ISPQGCSKWTGLGVFLDDLNEDLQIYSLGWGVGFQCMMICYPYRGNGAIIMTNADLGVHQ
CCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEEEEECCCEEEEEECCCCHHH
MEGIIGDVLKTLSL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]