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The map label for this gene is qor [C]

Identifier: 49186191

GI number: 49186191

Start: 3161598

End: 3162605

Strand: Direct

Name: qor [C]

Synonym: BAS3186

Alternate gene names: 49186191

Gene position: 3161598-3162605 (Clockwise)

Preceding gene: 49186179

Following gene: 49186202

Centisome position: 60.47

GC content: 38.39

Gene sequence:

>1008_bases
ATGAAAGCACAAATTATCCATTCTTTTGGGGATTCATCTGTATTTCAATTAGAAGAAGTTTCAAAACCAAAACTTTTACC
AGGTCATGTTCTAATCGATGTAAAAGCAACAAGTGTAAATCCAATCGATACAAAAATGCGTAGTGGTGCCGTTTCAGCAG
TCGCTCCTGAGTTTCCAGCTATATTACACGGCGATGTAGCTGGTATTGTTATTGAAGTCGGAGAAGGTGTTTCGAAATTC
AAATGTGGGGATGAAGTATACGGTTGTGCCGGAGGTTTTAAAGAAACTGGAGGTGCACTTGCAGAATTTATGCTTGCTGA
TGCGCGATTAATTGCTCATAAACCTAACAATATAACAATGGAAGAAGCAGCAGCTCTACCATTAGTTGCAATTACAGCTT
GGGAATCTTTATTTGATCGTGCAAATATTAAATCAGGTCAAAATGTGCTCATTCATGGAGCTACTGGTGGCGTAGGACAC
GTAGCCATTCAATTAGCTAAATGGGCTGGTGCTAACGTTTTCACAACTGCTTCTCAGCAGAACAAAATGGAAATAGCCCA
TCGTCTAGGAGCCGACGTAGCTATTAACTATAAAGAAGAATCTGTTCAAGAATCTGTTCAAGAATATGTTCAAAAACATA
CGAATGGCAACGGATTTGAAGTTATATTTGATACAGTAGGTGGCAAAAATCTTGATAACTCTTTCGAAGCTGCTGCAGTC
AACGGAACTGTCGTAACAATTGCAGCTCGTTCAACCCATGACCTCTCTCCTTTACACGCAAAAGGACTCTCTCTGCACGT
TACTTTTATGGCGTTAAAAATATTACATACAGATAAGCGTAATGATTGCGGAGAAATCTTAACGAAAATAACAAAAATTG
TAGAAGAAGGAAAACTTCGCCCATTGCTAGATTCTAAATCTTTTACGTTTGATGAAGTCGCACAAGCACATGAATATTTG
GAGTCGAATAAAGCAATAGGAAAAATAGTGTTGAAAAACGTTTGGTAA

Upstream 100 bases:

>100_bases
TTCCTCTTCTTTATATAAAATGCTCAATATCCAAATTCAAAATATTATACTTATTTTTCGTACTTTGCTATGCTATAAGC
ACAAACAGGAGGTATAAACA

Downstream 100 bases:

>100_bases
CTTTCACTTCATAATACAACTATTGTTGAAAAATAATAGAGGGATCGTTTTAAACGGTCATATTTTTTCTTAAGAGATAC
CACAGCGCCAAAATCGCTCC

Product: zinc-containing alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAQIIHSFGDSSVFQLEEVSKPKLLPGHVLIDVKATSVNPIDTKMRSGAVSAVAPEFPAILHGDVAGIVIEVGEGVSKF
KCGDEVYGCAGGFKETGGALAEFMLADARLIAHKPNNITMEEAAALPLVAITAWESLFDRANIKSGQNVLIHGATGGVGH
VAIQLAKWAGANVFTTASQQNKMEIAHRLGADVAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAV
NGTVVTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITKIVEEGKLRPLLDSKSFTFDEVAQAHEYL
ESNKAIGKIVLKNVW

Sequences:

>Translated_335_residues
MKAQIIHSFGDSSVFQLEEVSKPKLLPGHVLIDVKATSVNPIDTKMRSGAVSAVAPEFPAILHGDVAGIVIEVGEGVSKF
KCGDEVYGCAGGFKETGGALAEFMLADARLIAHKPNNITMEEAAALPLVAITAWESLFDRANIKSGQNVLIHGATGGVGH
VAIQLAKWAGANVFTTASQQNKMEIAHRLGADVAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAV
NGTVVTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITKIVEEGKLRPLLDSKSFTFDEVAQAHEYL
ESNKAIGKIVLKNVW
>Mature_335_residues
MKAQIIHSFGDSSVFQLEEVSKPKLLPGHVLIDVKATSVNPIDTKMRSGAVSAVAPEFPAILHGDVAGIVIEVGEGVSKF
KCGDEVYGCAGGFKETGGALAEFMLADARLIAHKPNNITMEEAAALPLVAITAWESLFDRANIKSGQNVLIHGATGGVGH
VAIQLAKWAGANVFTTASQQNKMEIAHRLGADVAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAV
NGTVVTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITKIVEEGKLRPLLDSKSFTFDEVAQAHEYL
ESNKAIGKIVLKNVW

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=365, Percent_Identity=33.1506849315069, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI22538446, Length=333, Percent_Identity=31.2312312312312, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI22538444, Length=333, Percent_Identity=31.2312312312312, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI194239674, Length=333, Percent_Identity=28.2282282282282, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI13236495, Length=333, Percent_Identity=28.2282282282282, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI194239676, Length=333, Percent_Identity=26.4264264264264, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI18379349, Length=327, Percent_Identity=28.1345565749235, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24308257, Length=361, Percent_Identity=24.9307479224377, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI41872631, Length=238, Percent_Identity=28.9915966386555, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI28557745, Length=251, Percent_Identity=30.2788844621514, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI197927207, Length=196, Percent_Identity=25.5102040816327, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI90669511, Length=211, Percent_Identity=29.8578199052133, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI226056130, Length=252, Percent_Identity=25, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI226059159, Length=252, Percent_Identity=25, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI226059133, Length=252, Percent_Identity=25, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1790485, Length=332, Percent_Identity=30.1204819277108, Blast_Score=114, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17507255, Length=335, Percent_Identity=29.2537313432836, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71987554, Length=363, Percent_Identity=29.4765840220386, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI212642053, Length=240, Percent_Identity=27.5, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17556000, Length=335, Percent_Identity=25.9701492537313, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=253, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323801, Length=334, Percent_Identity=27.8443113772455, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319520, Length=268, Percent_Identity=30.2238805970149, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=280, Percent_Identity=28.2142857142857, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=258, Percent_Identity=27.5193798449612, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320948, Length=403, Percent_Identity=22.8287841191067, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=259, Percent_Identity=25.8687258687259, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319401, Length=173, Percent_Identity=30.0578034682081, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=23.2558139534884, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581341, Length=372, Percent_Identity=26.0752688172043, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24581339, Length=372, Percent_Identity=26.3440860215054, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24581345, Length=277, Percent_Identity=28.8808664259928, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920632, Length=236, Percent_Identity=27.5423728813559, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI221330659, Length=236, Percent_Identity=27.5423728813559, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35921; Mature: 35921

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAQIIHSFGDSSVFQLEEVSKPKLLPGHVLIDVKATSVNPIDTKMRSGAVSAVAPEFPA
CCCEEEECCCCCCEEEHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKCGDEVYGCAGGFKETGGALAEFMLADARLIAHKPNNITM
EECCCCEEEEEECCCCCHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCH
EEAAALPLVAITAWESLFDRANIKSGQNVLIHGATGGVGHVAIQLAKWAGANVFTTASQQ
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHEEHHHHCCCCEEEECCCC
NKMEIAHRLGADVAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAV
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
NGTVVTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITKIVEEGKLR
CCEEEEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
PLLDSKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
>Mature Secondary Structure
MKAQIIHSFGDSSVFQLEEVSKPKLLPGHVLIDVKATSVNPIDTKMRSGAVSAVAPEFPA
CCCEEEECCCCCCEEEHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKCGDEVYGCAGGFKETGGALAEFMLADARLIAHKPNNITM
EECCCCEEEEEECCCCCHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCH
EEAAALPLVAITAWESLFDRANIKSGQNVLIHGATGGVGHVAIQLAKWAGANVFTTASQQ
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHEEHHHHCCCCEEEECCCC
NKMEIAHRLGADVAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAV
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
NGTVVTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITKIVEEGKLR
CCEEEEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
PLLDSKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA