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The map label for this gene is dxr1

Identifier: 49186165

GI number: 49186165

Start: 3134329

End: 3135486

Strand: Direct

Name: dxr1

Synonym: BAS3160

Alternate gene names: 49186165

Gene position: 3134329-3135486 (Clockwise)

Preceding gene: 49186155

Following gene: 49186168

Centisome position: 59.95

GC content: 36.01

Gene sequence:

>1158_bases
ATGGTAAAATATATATCCATTTTAGGTTCAACAGGATCCATCGGCACATCGGCATTAGATGTCGTTTCAGCTCATCCCGA
ACATTTTAAAATCGTCGGTTTAACCGCAAATTATAATATCGAGCTTCTTGAACAACAAATCAAAACGTTTCAACCTCGCA
TTGTAAGCGTCGCGACAAAAGAATTAGCAGACACGCTTCGTACGCGTATTTCAACCAACACAAAAATCACATACGGAACA
GATGGCTTAATTGCAGTAGCTACTCACCCTAATTCAAATCTTGTATTAAGTTCCGTCGTTGGTGTTTCAGGATTACTCCC
AACAATTGAAGCATTAAAAGCGAAGAAAGATATTGCCATCGCTAATAAAGAAACGTTAGTTGCAGCTGGTCATATTGTAA
CTGAACTGGCCAAACAAAACGGATGTCGTTTAATTCCAGTCGATAGCGAACATTCAGCTATTTTCCAATGTTTAAACGGA
GAAAATAATAAAGAAATTGACAAATTAATCGTTACAGCTTCTGGCGGTGCATTCCGTGATAAAACACGTGAAGAAATGAA
AACTCTACAAGCAAAAGATGCTTTAAAGCACCCAAACTGGTTAATGGGGGCAAAACTAACGATTGATTCTGCCACGTTAA
TGAATAAAGGATTTGAAGTAATGGAAGCGAGATGGTTATTTGATATTCCTTATGAAAAAATTAATGTAATGATTCATAAA
GAAAGCATTATTCATTCTTTAGTAGAGTTTATCGATGGATCAGTTATAGCACAGCTCGGTGCTCCTGATATGAGGATGCC
GATTCAATATGCGTTTCACTACCCTACTCGGCTGCCTTCTTCCTATGAAAAATTAAATTTATTAGAAATCGGTAGTTTAC
ATTTTGAAAAACCAGATTTAGAGAAGTTTCCTTGTCTACAATACGCATATGAATGTGGCAAAATTGGTGGTATTACTCCT
GCTGTATTAAACGCAGCAAATGAAATTGCGAATGCACTATTCTTAAAAAATGAAATTGCCTTTTTCGATATTGAAAAAAC
AATTTACAAAACAGTTGAAGCCCATCATAACGTAAAAGATCCTTCACTAGATGCTATATTAGAAGCGGATCAATGGGCAC
GCCAATATGCAAATCAATTGTTAATAAAAAAGAGCTAA

Upstream 100 bases:

>100_bases
AACCCGAATTTTCTATTTTATTTAGCAGGAATTTCCACTTCAATTGTCTAATATTATATAGGTTTGCAGAAATACTCGAA
ACAACTTTGGAGGTTTTTTC

Downstream 100 bases:

>100_bases
AACAGATAATACTGTTTTAGCTCTTTTTCCTACGTATTCAACTTAACAAATCGATAACCGTGCGTAACTAACACTTTTAA
GATCGCATACCCTGGAATTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 1; 1-deoxyxylulose-5-phosphate reductoisomerase 1; 2-C-methyl-D-erythritol 4-phosphate synthase 1

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGITP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Sequences:

>Translated_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGITP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS
>Mature_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGITP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=39.1414141414141, Blast_Score=293, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR1_BACAN (Q81N10)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_845693.1
- RefSeq:   YP_020043.1
- RefSeq:   YP_029417.1
- ProteinModelPortal:   Q81N10
- SMR:   Q81N10
- EnsemblBacteria:   EBBACT00000009002
- EnsemblBacteria:   EBBACT00000018754
- EnsemblBacteria:   EBBACT00000022801
- GeneID:   1085180
- GeneID:   2817385
- GeneID:   2849772
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3409
- KEGG:   bar:GBAA_3409
- KEGG:   bat:BAS3160
- TIGR:   BA_3409
- TIGR:   GBAA_3409
- GeneTree:   EBGT00050000001768
- HOGENOM:   HBG430762
- OMA:   GLLPTIE
- ProtClustDB:   PRK12464
- BioCyc:   BANT260799:BAS3160-MONOMER
- BioCyc:   BANT261594:GBAA3409-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42558; Mature: 42558

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
ELADTLRTRISTNTKITYGTDGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGITPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
ELADTLRTRISTNTKITYGTDGLIAVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGITPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629