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The map label for this gene is proC [H]

Identifier: 49185927

GI number: 49185927

Start: 2889919

End: 2890749

Strand: Reverse

Name: proC [H]

Synonym: BAS2921

Alternate gene names: 49185927

Gene position: 2890749-2889919 (Counterclockwise)

Preceding gene: 49185928

Following gene: 49185926

Centisome position: 55.29

GC content: 32.97

Gene sequence:

>831_bases
ATGAATAAACAAATAGGATTTATCGGATGTGGAAACATGGGTATTGCTATGATAGGTGGGATGATTAATAAAAATATAGT
GTCTCCAAATCAAATAATTTGTTCAGATTTAAACGTCAGTAATTTAAAAAATGCTAGTGATAAATATGGCATAACTATAA
CTACTAATAATAATGAAGTTGCTAACAGTGCCGACATTTTAATTTTATCAATTAAACCAGACTTATACACATCGGTAATT
AACCAAATAAAAAACCAAATAAAAAACCAAATAAAAAATGATGTAATTGTTGTAACTATTGCTGCAGGAAAAAGTATTAA
GAGCACTGAGAATGAATTTGATAGAAAGTTAAAGGTTATTAGAGTAATGCCGAATACACCGGTACTTGTTGGGGAAGGAA
TGTCTGCATTATCTTTTAATGAAATGGTTACAGAAAAAGATATAAAAGAGGTACTAAATATATTTAATAGTTTCGGCCAG
ACGGAGGTCGTAAATGAAAAATTAATGGATGTTGTTACATCTATTAGTGGTTCTTCTCCAGCATATGTGTATATGTTTAT
AGAAGCCATGGCAGATGCTGCTGTACTTGACGGTATGCCGAGAAAACAGGCTTATAAATTTGCGGCTCAGGCTGTATTAG
GTTCTGCAAAAATGGTATTGGAAACGGGAATACATCCAGGTGAATTGAAGGATATGGTTTGTTCTCCAGGGGGAACGACG
ATAGAAGCTGTAGCAACATTAGAAGAAAAAGGTTTAAGAACAGCTATCATTTCAGCTATGAAACGTTGTACGAAAAAATC
TATGGAAATGTCTCGTTTAACTAGTAAGTGA

Upstream 100 bases:

>100_bases
AAATTCTATTGATAAACCCAGTAATTGTAATAGCCCTAACTTAGAATAATAATTTCAAAATCAATAAAGTTTAGAATAGA
AGGAGCAAGATCAAATTATT

Downstream 100 bases:

>100_bases
GAAGATTTGTTTAGGCGTAACTTCATATCCATTAATGTAAGCTATTATTTAAATTAAAAGCTTGTTGCTATTCTCTTATA
GAGAGCGGGGCATAAAATTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPNQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYTSVI
NQIKNQIKNQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQ
TEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTT
IEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK

Sequences:

>Translated_276_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPNQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYTSVI
NQIKNQIKNQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQ
TEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTT
IEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
>Mature_276_residues
MNKQIGFIGCGNMGIAMIGGMINKNIVSPNQIICSDLNVSNLKNASDKYGITITTNNNEVANSADILILSIKPDLYTSVI
NQIKNQIKNQIKNDVIVVTIAAGKSIKSTENEFDRKLKVIRVMPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQ
TEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTT
IEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=277, Percent_Identity=37.1841155234657, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=35.7400722021661, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=35.7400722021661, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=35.1851851851852, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=52.9411764705882, Blast_Score=294, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=36.2264150943396, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=289, Percent_Identity=32.5259515570934, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=28.1786941580756, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=37.9061371841155, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=36.4312267657993, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.603550295858, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29867; Mature: 29867

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQIGFIGCGNMGIAMIGGMINKNIVSPNQIICSDLNVSNLKNASDKYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYTSVINQIKNQIKNQIKNDVIVVTIAAGKSIKSTENEFDRKLKVI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHEEEE
RVMPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSP
EECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
AYVYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTT
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCE
IEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
EHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKQIGFIGCGNMGIAMIGGMINKNIVSPNQIICSDLNVSNLKNASDKYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYTSVINQIKNQIKNQIKNDVIVVTIAAGKSIKSTENEFDRKLKVI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHEEEE
RVMPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSP
EECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
AYVYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTT
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCE
IEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
EHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]