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The map label for this gene is lysP [H]

Identifier: 49185868

GI number: 49185868

Start: 2834416

End: 2835882

Strand: Direct

Name: lysP [H]

Synonym: BAS2862

Alternate gene names: 49185868

Gene position: 2834416-2835882 (Clockwise)

Preceding gene: 49185865

Following gene: 49185869

Centisome position: 54.21

GC content: 39.67

Gene sequence:

>1467_bases
ATGAATAGCGCAACGAATCAAACTACCTCTCAAACAGAAACTACAAAAGGAAAAGGTGAATTAAGACGCGGTCTAAAATC
AAAGCACCTTACGATGATTTCTCTCGGCGGTACAATTGGTACCGGACTATTTCTTGCCAGCGGTGGTGTCATTCATTCAG
CTGGACCTGGCGGCGCATTAATTGCATACGCCGCAATTGGAATTATGGTTTACTTTTTAATGACAAGCTTAGCCGAACTC
ACAGCTTACATGCCTGTTACTGGATCTTTTAGCACGTACGCAACAAAATTTGTTGATCCATCACTTGGCTTTGCACTTGG
ATGGAACTATTGGTATAACTGGGCAATTACTATCGCTGCTGAACTAGCGGCTGTAACATTAATTATGAAATTTTGGTTTC
CAGATACTCCTTCCCTCATTTGGAGCGGATTATGTTTAGCTATTATTTTCCTTTTAAACTACTTATCTGTTAAAGGATTT
GGTGAATCTGAATATTGGTTCGCACTTATTAAAGTAGCTACGATTATTATCTTTTTAATTGTCGGGTTTATGATGATTTT
CGGAATTATGGGCGGCGAAACTGTTGGATTTAAAAACTTCACTGTTGCAGATGCACCATTTAACGGCGGCATCATGGCAA
TTATCGGTGTATTTATGGCAGCTGGTTTCTCATTCCAAGGTACTGAATTATTAGGTGTAGCTGCTGGTGAAACATCTGAT
CCAGAGCGTAATATTCCAAAAGCAATTCGTTCGATCTTTTGGCGTATCCTTTTATTCTATATCCTTGCGATTCTCGTTAT
CGGTTTATTAATTCCTTATACAACTGAAAGTCTTGCCGCAAGTGATGTAACAGTAAGTCCATTTACACTTATTTTTGAAA
AAGCGGGCGTTGCCTTCGCTGCTTCTGTTATGAACGCTGTTATTTTAACGGCAGTACTATCTGCTGGTAACTCTGGTATG
TATGCATCAACTCGTATGCTTTGGGACTTAGCTCGCCAAGGGAAAGCACCAAAGTTTCTTGGTAAATTAGATAGCCGCGG
CGTACCTGTTAACGCATTAATCGTAACATCGATTGTCGGTAGTATCGCTTTCATTGCTTCTTTATTCGGTGACGGTGTTG
TATACATTTGGTTACTAAATGCATCAGGAATGTCTGGCTTTATCGCATGGGTTGGAATCGCAATTAGTCATTACCGTTTC
CGCAAAGCATATATCGCACAAGGAAAAGATTTAAATGACTTACCTTATAGAGCAAAATGGTTCCCATTCGGACCAATCTT
CGCTTTTGCGCTTTGCGTCATCGTAATTTTAGGTCAAAACTACGGCGCATTTATGGGCGAATCAATCGATTGGAACGGCG
TACTCGTTTCTTACATCGGTTTACCACTCTTCTTAGTACTTTGGTTAGGATACAAATTTACGAAAAAAACAAAAGTCATT
CCACTTGATAAATGTGAACTAAAATAA

Upstream 100 bases:

>100_bases
GGGGTGGTTATTTGTGAAACGTTCCGCCAAATTCCTTTGGCGGTTTTTTGTATTTTTCTCCCCCGCTCCTTCCTATCTTA
CAAGAAAAGGAGTGTTGAAC

Downstream 100 bases:

>100_bases
AGTGAAACGAGCAAACAAATTTGTTTGCTCGTTTTTTATTGCAAACCTCTTTGCTTCCCTATTGCCCCTGTTTTTGCAAT
AATAAAGGAAATATAAATAA

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNSATNQTTSQTETTKGKGELRRGLKSKHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
TAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Sequences:

>Translated_488_residues
MNSATNQTTSQTETTKGKGELRRGLKSKHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
TAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK
>Mature_488_residues
MNSATNQTTSQTETTKGKGELRRGLKSKHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
TAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=62.5779625779626, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=470, Percent_Identity=38.936170212766, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=37.122969837587, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=36.1702127659575, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=36.4269141531323, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87081915, Length=427, Percent_Identity=33.9578454332553, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1790653, Length=349, Percent_Identity=37.5358166189112, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1789017, Length=394, Percent_Identity=34.2639593908629, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=36.1538461538462, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87081869, Length=406, Percent_Identity=24.8768472906404, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082023, Length=411, Percent_Identity=25.7907542579075, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082250, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=484, Percent_Identity=38.0165289256198, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6324061, Length=491, Percent_Identity=34.0122199592668, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322892, Length=498, Percent_Identity=36.9477911646586, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324990, Length=494, Percent_Identity=32.9959514170041, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=494, Percent_Identity=34.8178137651822, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6324924, Length=493, Percent_Identity=33.8742393509128, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6320717, Length=495, Percent_Identity=31.7171717171717, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321629, Length=511, Percent_Identity=30.9197651663405, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=425, Percent_Identity=35.0588235294118, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319542, Length=505, Percent_Identity=30.4950495049505, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6320251, Length=501, Percent_Identity=30.3393213572854, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322967, Length=466, Percent_Identity=31.3304721030043, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=495, Percent_Identity=30.9090909090909, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319824, Length=509, Percent_Identity=28.4872298624754, Blast_Score=240, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=31.8376068376068, Blast_Score=235, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324981, Length=487, Percent_Identity=30.3901437371663, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=474, Percent_Identity=27.4261603375527, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=553, Percent_Identity=27.124773960217, Blast_Score=170, Evalue=6e-43,
Organism=Drosophila melanogaster, GI281366235, Length=390, Percent_Identity=23.5897435897436, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007820, Length=390, Percent_Identity=23.5897435897436, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007818, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI85725152, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52753; Mature: 52753

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSATNQTTSQTETTKGKGELRRGLKSKHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCCCCCCCCHHHHHHCHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELTAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC
>Mature Secondary Structure
MNSATNQTTSQTETTKGKGELRRGLKSKHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCCCCCCCCHHHHHHCHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELTAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]