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The map label for this gene is hom [H]

Identifier: 49185441

GI number: 49185441

Start: 2430038

End: 2431081

Strand: Direct

Name: hom [H]

Synonym: BAS2433

Alternate gene names: 49185441

Gene position: 2430038-2431081 (Clockwise)

Preceding gene: 49185440

Following gene: 49185442

Centisome position: 46.48

GC content: 33.05

Gene sequence:

>1044_bases
ATGAAAATTAAAGTTGTACTATCAGGATATGGAACAGTAGGAAGAGAGTTTATAAAATTATTAAATGAAAAATATTTATA
TATAAATGAAACGTATGGAATAGATTTAGTGGTAAGCGGTGTATTAGGCAGAAATGTTGCAATACATAATGAAGATGGAT
TATCTATTCATCATTTATTAAGATATGGTGGCGGTAGCTGTGCAATTGAAAAATATATTGAACATCATCCAGAGGAACGT
GCAACAGATAACATAAGTGGTACAGTGCTGGTAGAATCAACAGTTACAAACCTTAAAGATGGAAATCCAGGGAAACAATA
TATAAAACAAGCGATTGAGAAAAAAATGGATATAGTAGCAATTTCAAAAGGTGCGCTAGTTACAAACTGGAGAGAAATAA
ATGAAGCTGCAAAAATCGCAAATGTACGAATTCGATACAGTGGGGCAACTGCTGCGGCATTACCAACACTTGATATCGGT
CAATTTAGTTTAGCTGGTTGCCATATTGAAAAAATAGAAGGAATATTAAATGGGACAACAAATTATATTCTTTCGAAAAT
GAATGAGGAAGATATTGCATTTGAAGAAGCACTGAAAGAAGCGCAAAGTAAAGGAATTGCTGAAACGAACCCAATATTAG
ATGTAAGTGGTTCTGATAGTGCGTGTAAATTGTTACTTTTGACAAACAGTTTAATGGGAACAGAGAATAAGCTTACAGAT
ATACATATTAAAGGAATCGAACATGTTACAAAACAACAAATTCGAAATGCGAAGGAACAAAATAAAATTATTAAATTGAT
AGCATCAGCCTATAAAGATAATGAAGGTAATGTGAATCTAAATGTTGAACCGTACAAATTACATAAAAATCATCCGCTAG
CAAATGTAAATGGAACAGAAAAAGGGATTACGTTCTTTACAGATACGATGGGCCAAGTTACTACAATTGGTGGTGCATCA
AATCCACGCGTAGCCGCAGCAGCAGCTTTAAAAGATATAATTAATTTATATCGTAAAGATTTGTCACGTATTAACAGGGA
GTAA

Upstream 100 bases:

>100_bases
TTTACCGAAATAGATAGTAATAAAGCGCTCTCGATGGAATTCGAGGGCGCTTTATATTATATTGAAAGAGGGCTTTGGTA
GAAAAATATAGGGGGATATT

Downstream 100 bases:

>100_bases
AGTTACTAATTGATTAAAGTTGTATTTTATAAAACCGTACCGCCCTTTATAAAAAATACATATGCAGTGGACCTTTTGAG
AATGAAATAAATATGCAAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDIAFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD
IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKLHKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS
NPRVAAAAALKDIINLYRKDLSRINRE

Sequences:

>Translated_347_residues
MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDIAFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD
IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKLHKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS
NPRVAAAAALKDIINLYRKDLSRINRE
>Mature_347_residues
MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDIAFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD
IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKLHKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS
NPRVAAAAALKDIINLYRKDLSRINRE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=229, Percent_Identity=24.4541484716157, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 38009; Mature: 38009

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLL
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHCCCEEEECCCCCHHHHHH
RYGGGSCAIEKYIEHHPEERATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVA
HHCCCHHHHHHHHHHCCHHHCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCCEEE
ISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTT
EECCCEEECHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEECCCHHHHHHHHHCCHH
NYILSKMNEEDIAFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECHHCCCCCCEEE
IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKLHKNHPLANVNGTE
EEECHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCCCCCCCC
KGITFFTDTMGQVTTIGGASNPRVAAAAALKDIINLYRKDLSRINRE
CCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLL
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHCCCEEEECCCCCHHHHHH
RYGGGSCAIEKYIEHHPEERATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVA
HHCCCHHHHHHHHHHCCHHHCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCCEEE
ISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTT
EECCCEEECHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEECCCHHHHHHHHHCCHH
NYILSKMNEEDIAFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECHHCCCCCCEEE
IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKLHKNHPLANVNGTE
EEECHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCCCCCCCC
KGITFFTDTMGQVTTIGGASNPRVAAAAALKDIINLYRKDLSRINRE
CCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]