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The map label for this gene is asd [H]

Identifier: 49185277

GI number: 49185277

Start: 2266606

End: 2267649

Strand: Direct

Name: asd [H]

Synonym: BAS2268

Alternate gene names: 49185277

Gene position: 2266606-2267649 (Clockwise)

Preceding gene: 49185274

Following gene: 49185278

Centisome position: 43.35

GC content: 37.45

Gene sequence:

>1044_bases
ATGAGTGAAAAGGGCTATCATTTAGCTGTTGTTGGGGCTACGGGTGCAGTAGGTCAGAAAATTATTGAACTGTTAGAAAA
AGAAACAAAGTTTAATATAGCTGAAGTTACGTTACTTTCGTCAAAAAGATCGGCTGGTAAGACAGTACAATTTAAAGGGC
GAGAGATCATTATACAAGAAGCAAAAATAAATAGCTTTGAAGGGATAGATATTGCCTTTTTTAGTGCTGGAGGAGAAGTT
TCTAGGCAATTTGTAAATCAAGCTGTCTCTAGTGGTGCAATCGTAATTGACAATACTAGTGAATACCGAATGGCACATGA
TGTACCGCTTGTTGTTCCGGAAGTGAATACGCACACTTTAAAGGAACATAAAGGGATAATAGCAGTTCCGAATTGTTCAG
CATTACAGATGGTAACAGCTCTTCAGCCAATACGAAAAGTATTCGGATTAGAACGAATTATCGTTTCCACTTATCAGGCT
GTATCGGGTTCTGGTATTCATGCGATTCAAGAATTAAAAGAACAGGCTAAGTCAATACTTGCAGGTGAAGAAGTGGAGAG
TACTATATTACCAGCGAAAAAAGATAAAAAACATTATCCAATTGCATTTAATGTACTTCCTCAAGTAGATATATTCACGG
ATAATGATTTCACCTTTGAAGAAGTAAAGATGATACAAGAAACGAAGAAAATTTTAGAAGACCCAAACTTGAAAATGGCA
GCTACTTGTGTGCGTGTTCCAGTTATATCAGGTCACTCAGAATCGGTTTATATAGAGCTTGAAAAAGAAGCAACTGTTGC
AGAAATTAAAGAAGTATTGTTTGATGCACCAGGTGTTATTTTGCAGGATAACCCTAGTGAACAGCTGTATCCAATGCCAT
TATATGCAGAAGGGAAAATAGATACATTTGTCGGTAGAATTAGAAAAGATCCTGATACACCAAACGGATTCCATCTTTGG
ATCGTTTCCGATAATTTATTAAAAGGTGCGGCGTGGAACTCGGTGCAAATTGCAGAAACGATGGCGGAAGAGGGAATCAT
TTAG

Upstream 100 bases:

>100_bases
GTGAATGATTATATCACGTATTTCAATTTTCCAAATGATTAAATTCCTTATAAAATGAAATTGTAGAAATATTTATTCAT
TTAATATTGGAGGAGAAAAG

Downstream 100 bases:

>100_bases
TATTAACGAAACTAGGGAACTGTTAAAGATTACAGTTTCCTAGTTTTTATTTTATAACTGTTCGCTTTATTCCAGCCGTA
TTTGATTTGAAAGACAGTAA

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSEKGYHLAVVGATGAVGQKIIELLEKETKFNIAEVTLLSSKRSAGKTVQFKGREIIIQEAKINSFEGIDIAFFSAGGEV
SRQFVNQAVSSGAIVIDNTSEYRMAHDVPLVVPEVNTHTLKEHKGIIAVPNCSALQMVTALQPIRKVFGLERIIVSTYQA
VSGSGIHAIQELKEQAKSILAGEEVESTILPAKKDKKHYPIAFNVLPQVDIFTDNDFTFEEVKMIQETKKILEDPNLKMA
ATCVRVPVISGHSESVYIELEKEATVAEIKEVLFDAPGVILQDNPSEQLYPMPLYAEGKIDTFVGRIRKDPDTPNGFHLW
IVSDNLLKGAAWNSVQIAETMAEEGII

Sequences:

>Translated_347_residues
MSEKGYHLAVVGATGAVGQKIIELLEKETKFNIAEVTLLSSKRSAGKTVQFKGREIIIQEAKINSFEGIDIAFFSAGGEV
SRQFVNQAVSSGAIVIDNTSEYRMAHDVPLVVPEVNTHTLKEHKGIIAVPNCSALQMVTALQPIRKVFGLERIIVSTYQA
VSGSGIHAIQELKEQAKSILAGEEVESTILPAKKDKKHYPIAFNVLPQVDIFTDNDFTFEEVKMIQETKKILEDPNLKMA
ATCVRVPVISGHSESVYIELEKEATVAEIKEVLFDAPGVILQDNPSEQLYPMPLYAEGKIDTFVGRIRKDPDTPNGFHLW
IVSDNLLKGAAWNSVQIAETMAEEGII
>Mature_346_residues
SEKGYHLAVVGATGAVGQKIIELLEKETKFNIAEVTLLSSKRSAGKTVQFKGREIIIQEAKINSFEGIDIAFFSAGGEVS
RQFVNQAVSSGAIVIDNTSEYRMAHDVPLVVPEVNTHTLKEHKGIIAVPNCSALQMVTALQPIRKVFGLERIIVSTYQAV
SGSGIHAIQELKEQAKSILAGEEVESTILPAKKDKKHYPIAFNVLPQVDIFTDNDFTFEEVKMIQETKKILEDPNLKMAA
TCVRVPVISGHSESVYIELEKEATVAEIKEVLFDAPGVILQDNPSEQLYPMPLYAEGKIDTFVGRIRKDPDTPNGFHLWI
VSDNLLKGAAWNSVQIAETMAEEGII

Specific function: Unknown

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788658, Length=348, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789841, Length=361, Percent_Identity=25.207756232687, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320362, Length=399, Percent_Identity=28.3208020050125, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR012080
- InterPro:   IPR005986
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 38146; Mature: 38015

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKGYHLAVVGATGAVGQKIIELLEKETKFNIAEVTLLSSKRSAGKTVQFKGREIIIQE
CCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCEEEEEE
AKINSFEGIDIAFFSAGGEVSRQFVNQAVSSGAIVIDNTSEYRMAHDVPLVVPEVNTHTL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEEECCCCHHH
KEHKGIIAVPNCSALQMVTALQPIRKVFGLERIIVSTYQAVSGSGIHAIQELKEQAKSIL
HHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AGEEVESTILPAKKDKKHYPIAFNVLPQVDIFTDNDFTFEEVKMIQETKKILEDPNLKMA
CCCHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEE
ATCVRVPVISGHSESVYIELEKEATVAEIKEVLFDAPGVILQDNPSEQLYPMPLYAEGKI
EEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCEECCCEEECCCH
DTFVGRIRKDPDTPNGFHLWIVSDNLLKGAAWNSVQIAETMAEEGII
HHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SEKGYHLAVVGATGAVGQKIIELLEKETKFNIAEVTLLSSKRSAGKTVQFKGREIIIQE
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCEEEEEE
AKINSFEGIDIAFFSAGGEVSRQFVNQAVSSGAIVIDNTSEYRMAHDVPLVVPEVNTHTL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEEECCCCHHH
KEHKGIIAVPNCSALQMVTALQPIRKVFGLERIIVSTYQAVSGSGIHAIQELKEQAKSIL
HHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AGEEVESTILPAKKDKKHYPIAFNVLPQVDIFTDNDFTFEEVKMIQETKKILEDPNLKMA
CCCHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEE
ATCVRVPVISGHSESVYIELEKEATVAEIKEVLFDAPGVILQDNPSEQLYPMPLYAEGKI
EEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCEECCCEEECCCH
DTFVGRIRKDPDTPNGFHLWIVSDNLLKGAAWNSVQIAETMAEEGII
HHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8098035; 9384377; 8345520 [H]