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The map label for this gene is fumC

Identifier: 49184651

GI number: 49184651

Start: 1655437

End: 1656825

Strand: Direct

Name: fumC

Synonym: BAS1637

Alternate gene names: 49184651

Gene position: 1655437-1656825 (Clockwise)

Preceding gene: 49184650

Following gene: 49184654

Centisome position: 31.66

GC content: 37.51

Gene sequence:

>1389_bases
ATGGAGTACAGAATTGAAAGAGATACATTAGGAGAAATAAAAGTTCCAGCTGATAAATTATGGGCAGCACAAACACAACG
TAGTAAAGAAAACTTCCCGATTGGAACAGAGCAAATGCCGCTTGAAATTGTAAAAGCATTTGCAATTTTAAAGAAGAGTG
CAGCGCTTAGCAATCAAAAATTAGGAAAGCTATCAGAAGAAAAAGCAGAAGCAATTGTGGTAGCTGCTGACGAAATCATT
GCAGGGAAATGGAATGAACATTTTCCGCTTGTCGTGTGGCAAACAGGTAGTGGTACACAATCAAACATGAATGTGAATGA
AGTAATTGCAAATCGTGGGAATCAAATTTTGAAAGAAAAGGGATCTGACGTACATATTCATCCGAATGATGATGTGAACA
TGTCCCAAAGTTCAAATGATACATTTCCAACAGCGCTTCATGTAGCATGTGTACTCGCAGTAGAAAATCACGTATTACCA
GCTATTACGAAATTAAAAGAAACGTTAGCAGAAAAAGTAACTGCATTTGAACATATTATAAAAATTGGTCGTACACATTT
ACAAGATGCGACACCGTTAACATTAGGACAAGAAATTAGTGGATGGCACCGTATGCTTGAAAAAACAGAGCGTATGATTG
CAGAGAGCAATACATATATGAAAGAGCTTGCGATTGGTGGTACAGCAGTTGGAACAGGTATTAACGCTCATCCTAAATTT
GGTGAGATGGTATCAGAGGAAATTAGCCAATTTACAGGTAAACAATTTATTTCTGCACCAAATAAGTTCCATGCATTAAC
GAGCCATGATGAAGTTGTATATACTCACGGTGCATTAAAAGCATTAGCTGCGGATTTAATGAAAATCGCTAACGATGTAC
GTTGGCTGGCAAGTGGTCCACGTAGTGGTTTAGGAGAAATTATTATTCCGGCGAATGAGCCAGGAAGCTCTATTATGCCA
GGTAAAGTAAATCCAACGCAAAGTGAAGCGTTAACGATGGTTGTAGCGCAAGTGATGGGAAATGACGCAACAATCGGATT
TGCTGCGAGTCAAGGTAATTTTGAGTTAAACGTATTTAAACCTGTTATTGCGTATAACTTCTTACAATCCGCTCACTTAT
TAGCAGATGCAATTGTTTCATTTAATGATAATTGTGCAGTTGGTATTGAAGCTGATGAAGAAATCATTAAAGAGAATGTG
AATCGTTCATTAATGCTTGTTACAGCATTAAACCCGCATATCGGATATGAAAATGCAGCAAAAATTGCGAAGCATGCTCA
TAAAGAAGGGTTAACTTTAAAAGAAGCAGCATTGCAATCTGGACTACTAACAGAAGAGCAATTTAATGAAATTGTCGATC
CGAAAAAAATGATTGCTCCGAAAGAGTAA

Upstream 100 bases:

>100_bases
ATATAGAATATCTATATATAAGAGTGAGAATTCTTATCATTTAAGAGAAAGTCTGTTATTATAAGAGATGTAGGTATTAT
ATTTTCAAGGGGATGAAAAC

Downstream 100 bases:

>100_bases
TAAAAAAAGCCGAGATTCTTTGTTTAGAATCTTGGCTTTTTTAATATTTATCTTTTCTATTTGTATTACTGTAAGTACCA
AAATAAATTATTTGTTAGCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVVAADEII
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEIIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFNEIVDPKKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVVAADEII
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEIIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFNEIVDPKKMIAPKE
>Mature_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVVAADEII
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEIIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFNEIVDPKKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=59.0909090909091, Blast_Score=531, Evalue=1e-151,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.2691466083151, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.3947939262473, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=58.1344902386117, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=57.0121951219512, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=57.7006507592191, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.8965517241379, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.8965517241379, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.9568965517241, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.763440860215, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.2365591397849, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_BACAN (Q81SA0)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_844195.1
- RefSeq:   YP_018408.1
- RefSeq:   YP_027903.1
- ProteinModelPortal:   Q81SA0
- SMR:   Q81SA0
- EnsemblBacteria:   EBBACT00000008169
- EnsemblBacteria:   EBBACT00000015588
- EnsemblBacteria:   EBBACT00000019515
- GeneID:   1086574
- GeneID:   2818045
- GeneID:   2851297
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1767
- KEGG:   bar:GBAA_1767
- KEGG:   bat:BAS1637
- TIGR:   BA_1767
- TIGR:   GBAA_1767
- GeneTree:   EBGT00070000031773
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   BANT260799:BAS1637-MONOMER
- BioCyc:   BANT261594:GBAA1767-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50345; Mature: 50345

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 99-99

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVVAADEIIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCCHHHHHCEEEEEECHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEIIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFNEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVVAADEIIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCCHHHHHCEEEEEECHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEIIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFNEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629