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The map label for this gene is gltT [H]

Identifier: 49184358

GI number: 49184358

Start: 1373996

End: 1374712

Strand: Direct

Name: gltT [H]

Synonym: BAS1341

Alternate gene names: 49184358

Gene position: 1373996-1374712 (Clockwise)

Preceding gene: 49184357

Following gene: 49184359

Centisome position: 26.28

GC content: 35.43

Gene sequence:

>717_bases
ATGTTTTACGTAACGAACCAAGTTATGAAATTTGCACCATTTGGTGTGTTCGCATTGATTGGTGTTACAGTATCTACATT
CGGTTTAGCTTCATTAATTCCGTTAGGGAAATTATTAATTGTAGTATACGGGGCAATGATTTTCTTCGTTGTAGTTGTCT
TAGGACTTACAGCGAAAATATTTGGAATTAACATTTTCCAATTCTTTAAAATTTTAAAAGACGAACTGATCTTAGCGTAT
TCAACAGCAAGTTCAGAAACAGTTTTACCGAAAATTATGGAGAAAATGGAGAAGTTCGGTTGTCCGAAAGCAATTACATC
TTTCGTTATTCCGACAGGTTATTCATTTAACTTAGATGGATCAACTTTATATCAAGCAATTGCAGCTATTTTCTTAGCGC
AAATGTACGGTATTGATTTATCTATTACAGAACAAATTACATTATTACTTGTATTAATGGTTACATCAAAAGGTATCGCA
GGTGTACCGGGCGTATCATTCGTTGTATTATTAGCGACACTTGGTACAGTAGGTATTCCAGCTGAAGGCTTAGCCTTCAT
CGCCGGTATTGACCGTATTTTAGATATGGCTCGTACAGCAGTTAACGTTGTAGGTAACTCTTTAGCAGCTGTAGTTATGT
CTAAGTGGGAAGGTCAATATGACGCTGAAAAAGGACAAGCTTATTTGAAAGAAATTTCTAATAAGCAAGCAGCTTAA

Upstream 100 bases:

>100_bases
TTGCTATTATCTTCTTCTCAGTATTATTTGGTTTAGGTGTAGCAGCAATTGGTGAAAGAGGAAGACCGGTTCTTCAATTT
TCCAAGGTGTAGCTGATGCA

Downstream 100 bases:

>100_bases
TTATAATTTGAAAAAAGCTCTCACATAATATGTGAGGGCTTTTCTATATAGAAGGGAAGCGGACGTAATGAAACGTAAAT
ATGGTGACGGTTCTTCGTGG

Product: proton/glutamate symporter protein, C-terminus

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLGLTAKIFGINIFQFFKILKDELILAY
STASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQMYGIDLSITEQITLLLVLMVTSKGIA
GVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISNKQAA

Sequences:

>Translated_238_residues
MFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLGLTAKIFGINIFQFFKILKDELILAY
STASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQMYGIDLSITEQITLLLVLMVTSKGIA
GVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISNKQAA
>Mature_238_residues
MFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLGLTAKIFGINIFQFFKILKDELILAY
STASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQMYGIDLSITEQITLLLVLMVTSKGIA
GVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISNKQAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=190, Percent_Identity=37.3684210526316, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI169790839, Length=243, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4827012, Length=167, Percent_Identity=35.9281437125749, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI66773030, Length=218, Percent_Identity=31.651376146789, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI21314632, Length=229, Percent_Identity=29.6943231441048, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI301601644, Length=185, Percent_Identity=30.8108108108108, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239697, Length=153, Percent_Identity=34.640522875817, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI223468566, Length=233, Percent_Identity=27.8969957081545, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI223468564, Length=233, Percent_Identity=27.8969957081545, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI5032093, Length=233, Percent_Identity=27.8969957081545, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI262359914, Length=243, Percent_Identity=28.3950617283951, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790514, Length=235, Percent_Identity=68.5106382978723, Blast_Score=335, Evalue=1e-93,
Organism=Escherichia coli, GI1789947, Length=238, Percent_Identity=45.3781512605042, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788024, Length=219, Percent_Identity=29.2237442922374, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1789473, Length=203, Percent_Identity=26.6009852216749, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71983106, Length=228, Percent_Identity=33.7719298245614, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=228, Percent_Identity=33.7719298245614, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17537407, Length=214, Percent_Identity=31.3084112149533, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=206, Percent_Identity=34.4660194174757, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=226, Percent_Identity=32.3008849557522, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=172, Percent_Identity=34.8837209302326, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193206654, Length=237, Percent_Identity=27.4261603375527, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=226, Percent_Identity=27.4336283185841, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17137668, Length=226, Percent_Identity=27.4336283185841, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24583023, Length=226, Percent_Identity=27.4336283185841, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI281360481, Length=212, Percent_Identity=31.6037735849057, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281360483, Length=212, Percent_Identity=31.6037735849057, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137666, Length=212, Percent_Identity=31.6037735849057, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 25492; Mature: 25492

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLGLTAKI
CCEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDG
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCH
STLYQAIAAIFLAQMYGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
AEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISNKQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLGLTAKI
CCEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDG
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCH
STLYQAIAAIFLAQMYGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
AEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSKWEGQYDAEKGQAYLKEISNKQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]