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The map label for this gene is hisE

Identifier: 49184340

GI number: 49184340

Start: 1354687

End: 1355010

Strand: Direct

Name: hisE

Synonym: BAS1323

Alternate gene names: 49184340

Gene position: 1354687-1355010 (Clockwise)

Preceding gene: 49184339

Following gene: 49184341

Centisome position: 25.91

GC content: 32.1

Gene sequence:

>324_bases
ATGGAAAATACCTTCAAATTACTATTCGAAACAATTGAAGAACGAAAGAGAAATCCACTTCCTGAATCATATACAAATTA
CTTGTTTTCAAAAGGAGAAGATAAAATTTTAAAGAAAATTGGTGAGGAATGCACGGAAGTAATTATCGCATCTAAAAATA
ATGATAAAGAAGAGCTGGTGAAAGAAATGGTTGATGTATTGTATCACTGCTTCGTGTTATTAGCCGAAAAAAATATACCA
TTAGAAGATATTATGGAGGAAGTGACAGAAAGAAATGGGAAGCTTTCGAGAGTAGGGGACAGAAGAGAAATAGATACATT
ATAG

Upstream 100 bases:

>100_bases
GATCAAGATGCAATCGTTGTTTTCGTAAAACAAGTAGGACCTGCTTGCCATACGGGAGAAAAAACGTGTTTTCATTACAA
AATTATATAGGGGGATACAT

Downstream 100 bases:

>100_bases
GGGGAATAGGTATGAAAGTGGATTATCACATTCATTTAGAAGAAGGACCATATTCAATAGGGTGGCTAGCTAAAATAAAT
GAAGCACTGCAACATTATGA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNIP
LEDIMEEVTERNGKLSRVGDRREIDTL

Sequences:

>Translated_107_residues
MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNIP
LEDIMEEVTERNGKLSRVGDRREIDTL
>Mature_107_residues
MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNIP
LEDIMEEVTERNGKLSRVGDRREIDTL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=83, Percent_Identity=33.7349397590361, Blast_Score=59, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_BACAA (C3P507)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002865923.1
- ProteinModelPortal:   C3P507
- SMR:   C3P507
- EnsemblBacteria:   EBBACT00000130547
- GeneID:   7852736
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1499
- GeneTree:   EBGT00050000000893
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12568; Mature: 12568

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELV
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KEMVDVLYHCFVLLAEKNIPLEDIMEEVTERNGKLSRVGDRREIDTL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELV
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KEMVDVLYHCFVLLAEKNIPLEDIMEEVTERNGKLSRVGDRREIDTL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA