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The map label for this gene is comC [H]

Identifier: 49184237

GI number: 49184237

Start: 1266057

End: 1266779

Strand: Direct

Name: comC [H]

Synonym: BAS1219

Alternate gene names: 49184237

Gene position: 1266057-1266779 (Clockwise)

Preceding gene: 49184236

Following gene: 49184238

Centisome position: 24.21

GC content: 34.16

Gene sequence:

>723_bases
ATGTTCACTTATGTATATGCATTGTTAGTTGGGATGGTGTTTGGTTCCTTTTTTATGTTAATTGCGATGAGAATTCCGCT
AGGTGAGTCTATCATTATCCCGCGTTCACATTGTCATTATTGTAAGTATGTACTCAAGCCAAAAGAATTAATTCCAATCA
TTTCTTTTTGTATACAAAGGGGACGTTGTACGAATTGTAAGAGGAAAATTTCAATTTTGTACGTAATATTTGAACTTGTA
ACCGGAATAATATGTCTTCTTACTGTATATATGATTGGGGTGGAACGAGAGCTTATCATCATTTTATCACTTTTCTCGTT
ACTTCTCATTATTTCAGTTACAGATTACATATATATGTTAATCCCTAATCGTATTTTAGCTTGGTTCTCTTGTTTACTTA
TTTTAGAATGTGTTTTTGTACCGTTAGTCACTTGGACAGAGAGTATAGTTGGGAGTGGCGTTATATTCATTTTGTTATAC
TGCATGCAAAAGATATATCCAGAAGGGCTTGGTGGAGGGGATATAAAACTACTTTCGTTACTTGGATTTATTGCGGGACT
GAAAGGGGTTTTTATGATTTTATTTTTATCATCTTTCTTTAGTCTTTGTTTCTTTGGAGCTGGTCTCGTATTAAAACGTA
TGAAAATGAGGACTCAAATACCGTTTGGCCCTTTTATTAGCCTTGGGGCAATTTGTTACATGTTGGTCACGTATGCAAAA
TAG

Upstream 100 bases:

>100_bases
CAGGCCAGAAAATGGCCTGCTTTTTTAATAGAATAGAGATAATATGAAGTAGAAGTTCTCTCCTTTTTTTGCTATGTTCT
TCTGGAAAGGAGAGGAAGGG

Downstream 100 bases:

>100_bases
AGAGGGGATAGAAAATGAATGTATATATGGATGATCAAAGAAGTTGTCCGTACGGGTATGTGCTCGCAACTACAGTAGAA
TGTGCCCTGCAAATGGTTCG

Product: late competence protein comC

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MFTYVYALLVGMVFGSFFMLIAMRIPLGESIIIPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVIFELV
TGIICLLTVYMIGVERELIIILSLFSLLLIISVTDYIYMLIPNRILAWFSCLLILECVFVPLVTWTESIVGSGVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIAGLKGVFMILFLSSFFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK

Sequences:

>Translated_240_residues
MFTYVYALLVGMVFGSFFMLIAMRIPLGESIIIPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVIFELV
TGIICLLTVYMIGVERELIIILSLFSLLLIISVTDYIYMLIPNRILAWFSCLLILECVFVPLVTWTESIVGSGVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIAGLKGVFMILFLSSFFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK
>Mature_240_residues
MFTYVYALLVGMVFGSFFMLIAMRIPLGESIIIPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVIFELV
TGIICLLTVYMIGVERELIIILSLFSLLLIISVTDYIYMLIPNRILAWFSCLLILECVFVPLVTWTESIVGSGVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIAGLKGVFMILFLSSFFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27167; Mature: 27167

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
9.2 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
9.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]