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The map label for this gene is prsA

Identifier: 49184104

GI number: 49184104

Start: 1137581

End: 1138438

Strand: Reverse

Name: prsA

Synonym: BAS1084

Alternate gene names: 49184104

Gene position: 1138438-1137581 (Counterclockwise)

Preceding gene: 49184106

Following gene: 49184101

Centisome position: 21.77

GC content: 33.33

Gene sequence:

>858_bases
ATGAGAGGAAAACATATTTTCATTATTACTGCACTAATAAGTATATTAATGCTAGCTGCTTGCGGGCAAAAAAATAGCTC
GGCTACAGTCGCTACGGCAACAGACTCAACCATTACGAAGAGCGACTTCGAAAAACAGTTGAAAGATCGTTACGGAAAAG
ACATGTTATACGAAATGATAGCGCAAGACGTTATCACGAAAAAATATAAAGTATCTGACGATGATGTAGATAAAGAAGTA
CAAAAAGCGAAAAGTCAATACGGAGATCAATTCAAAAACGTGTTGAAAAACAACGGTTTAAAAGATGAAGCTGATTTTAA
AAATCAAATTAAGTTCAAACTTTCTATGAATAAAGCAATTAAACAAAGTGTTACAGAAAAAGACGTGAAAGACCACTACA
AACCAGAAATTAAAGCGAGCCACATTTTAGTAAGTGACGAAAATGAAGCAAAAGAAATAAAGAAAAAATTAGATACTGGT
GCTTCATTTGAAGAACTAGCAAAACAAGAATCGCAAGACCTACTATCAAAAGAGAAAGGCGGAGACCTCGGATACTTCCA
TTCAGGTGCAATGACACCTGAATTTGAAACAGCTGCCTACAAACTAAAAATTGGTCAAATTAGTGATCCTGTCCAATCAC
CAAATGGTTATCACATTATTAAACTAACTGGTAAAAAAGATCTAAAACCTTACGATGAGGTAAAAAACTCTATTCGCAAA
AACTTAGAGGAAGAACGTACTGCTGATCCTATATTTGGTAAAAAATTATTACAAAGTGAATTAAAAAAAGCAAATATTAA
AATAAACGATAGTGAGTTGGAAGATACGTTTACTATTGTTTCTCCGCAAGGAAATTAA

Upstream 100 bases:

>100_bases
TGTACTTTTTTACATTTTACAGGAAAAAACATTAAAAATTCACTTCATGTTCACTTCTATATTCTACAATAGCGATAACA
TATTCGGATGAGGTGTTAGC

Downstream 100 bases:

>100_bases
AAAAGCACAACCTTATTTTTTCAGATAAGGTTGTGCTTTTTTAATCTTTCATCAATATTTTCAACTTTTTCTTCAAGCTT
TTATAATGCCAATTGATGTG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVDKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDTG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN

Sequences:

>Translated_285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVDKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDTG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
>Mature_285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVDKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDTG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

Organism=Escherichia coli, GI1786645, Length=167, Percent_Identity=28.1437125748503, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=38.0952380952381, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=105, Percent_Identity=43.8095238095238, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRSA2_BACAN (Q81TU1)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843648.1
- RefSeq:   YP_017783.1
- RefSeq:   YP_027356.1
- ProteinModelPortal:   Q81TU1
- SMR:   Q81TU1
- EnsemblBacteria:   EBBACT00000013243
- EnsemblBacteria:   EBBACT00000018188
- EnsemblBacteria:   EBBACT00000020041
- GeneID:   1089182
- GeneID:   2817771
- GeneID:   2848589
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1169
- KEGG:   bar:GBAA_1169
- KEGG:   bat:BAS1084
- TIGR:   BA_1169
- TIGR:   GBAA_1169
- GeneTree:   EBGT00050000000187
- HOGENOM:   HBG712792
- OMA:   KAKSQYG
- ProtClustDB:   PRK03002
- BioCyc:   BANT260799:BAS1084-MONOMER
- BioCyc:   BANT261594:GBAA1169-MONOMER
- BRENDA:   5.2.1.8
- HAMAP:   MF_01145
- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 32079; Mature: 32079

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMI
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVDKEVQKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHHH
KQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDTGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
CCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCC
>Mature Secondary Structure
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMI
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVDKEVQKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHHH
KQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDTGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
CCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539