Click here to switch to the map view.

The map label for this gene is ntdR [H]

Identifier: 49184035

GI number: 49184035

Start: 1067942

End: 1068682

Strand: Direct

Name: ntdR [H]

Synonym: BAS1014

Alternate gene names: 49184035

Gene position: 1067942-1068682 (Clockwise)

Preceding gene: 49184034

Following gene: 49184036

Centisome position: 20.42

GC content: 38.6

Gene sequence:

>741_bases
GTGTCGACTATAGAGGACGTGGCGAAATTAGCGGGGTTATCAAGGACAACGGTTTCTAGGGTGATTAATAATCATCCATA
TGTTTCAGATGAGAAGAAAAAAAGGGTTCAATTAGCAATGAAGCATTTAGGCTTTGTTCCTAATTCTGCGGCGAGAAGGC
TTCGTAAACAAAAAACGGAAACAATTGCGGTGCTAGTTCCAAGGATTACAAATCCTTTCTTCAGTAGATTTATTGAAGCA
ATCGAGATTGCTGCTTCTGAACATAAATATAAACTGATTATTTGTCAAACAAGATATTTACCGGAAAAAGAGATGGAGTA
TTTACAATTATTATCTACGAAACAAGTGGATGGGATTATTCTATGTTCATTAGAAAATCCGTGGGAAGATGTAGAGCCAT
ACTTACAACACGGTCCAATCGTGTTATGTAATGAATATATTGAGGAAGCAAATATTCCAACAGTGAAGTTTGATCATGCG
CAAGGAGCATACATAGCTGCGAAGCATGTGTTAGAACAAGGATATCGTAATCTTATTTTTTGCCGTGGTAACGAAACCAA
AGTTGTTAGCCAACAGCGAAAAATGGGCTTTTTACGTGCCATAACGGAAAAGAGCCGCCAAGTAGAAGCGATCGATTTTC
TTGAAAACGCTTTCTCTTGGGAAGATGGCAAACGAATATTCCATGAAGTATTGAAAGACAAAAAAATCCTACCGCGATTT
TGGCAGGAGGCGATGAGGTAG

Upstream 100 bases:

>100_bases
TATTAATATAGTAAAATCATAAGAAGCCGTATTGCAGTTTCCAATAATATACTATATAATCAATTTAAGAAAACGTTTTC
ATTCAAAGGGGGAGAATTTC

Downstream 100 bases:

>100_bases
CAGCTGGAATTATTTCAGAGGCGAAACGCCATAATTGGAGCATTCCAGATGATCTCGCTGTTATCGGTTTTGATAATCAA
ATTTTATCACAGATTACAGA

Product: LacI family sugar-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEA
IEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHA
QGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKILPRF
WQEAMR

Sequences:

>Translated_246_residues
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEA
IEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHA
QGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKILPRF
WQEAMR
>Mature_245_residues
STIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEAI
EIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQ
GAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKILPRFW
QEAMR

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=231, Percent_Identity=30.3030303030303, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787948, Length=239, Percent_Identity=30.9623430962343, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789202, Length=206, Percent_Identity=30.5825242718447, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1790194, Length=203, Percent_Identity=29.064039408867, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788474, Length=205, Percent_Identity=28.2926829268293, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790689, Length=192, Percent_Identity=26.5625, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790715, Length=201, Percent_Identity=28.8557213930348, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789068, Length=209, Percent_Identity=27.7511961722488, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI48994940, Length=236, Percent_Identity=25.8474576271186, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787906, Length=197, Percent_Identity=23.8578680203046, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786268, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787580, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786540, Length=244, Percent_Identity=24.1803278688525, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 28563; Mature: 28432

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTE
CCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGII
HHEEHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
LCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQGAYIAAKHVLEQGYRNLIF
EEECCCCHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEE
CRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKILPRF
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
WQEAMR
HHHHCC
>Mature Secondary Structure 
STIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTE
CHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGII
HHEEHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
LCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQGAYIAAKHVLEQGYRNLIF
EEECCCCHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEE
CRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKILPRF
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
WQEAMR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]