Click here to switch to the map view.

The map label for this gene is hemZ [H]

Identifier: 49183855

GI number: 49183855

Start: 882702

End: 884198

Strand: Direct

Name: hemZ [H]

Synonym: BAS0831

Alternate gene names: 49183855

Gene position: 882702-884198 (Clockwise)

Preceding gene: 49183852

Following gene: 49183856

Centisome position: 16.88

GC content: 36.81

Gene sequence:

>1497_bases
GTGATAATGTTGTTAATTTCAATTAAAACGTTACAAGATGATCGTTTTTTACGTCCGCTGCAAAATATTAGCGGCTTATT
TTTTGAAGATAGTACGATTGGATTTGAACAAGAGGAAGCAAATCTTATCGTTGATATACACATTGAAGAGAATGTGAAAG
CATCAGCTCGTTTAACAGATGTTGCGACTGGAAATGTGTATGAAGAAACATTCGCAAAAGATTTATCTGCTTTTACAGAT
GAAAAAGAGCGTATGAAGCAAGTGAAGCACGTTGTTTCTTATGTATATCTTTCTGTTCTTCAGCAGTTAACTGGTATTGA
GCAAAGCTGGGGTATTTTAACGGGAGTTCGTCCGACAAAACTTCTTCATAAAATGCTTCAAAATGGTATGTCAAAAGAAG
AGGCGCACCAAGAACTTCGTGAAAGTTATTTAATTCATGAAGAGAAAATTGAACTTCTTCAGCGTATTGTTGACTGCCAA
TTAGCGGTAGTTCCGGATTTATATCGTTTGAAAGAGGAAGTAAGTATTTATATCGGTATTCCATTCTGCCCAACAAAATG
TGCATATTGTACATTCCCAGCGTATGCAATTAACGGACGTCAAGGTTCTGTTGATTCATTCTTAGGTGGTTTACATTATG
AAGTTCGTGAAATTGGTAAGTTTTTAAAAGAAAAAGGTGTAACAGTTACGACGATTTATTACGGCGGCGGTACACCGACA
AGTATTACAGCAGAAGAGATGGATATGCTGTATGAAGAAATGTATGAAGCGTTCCCAGATGTGAAAAATGTGCGTGAAGT
AACAGTTGAGGCAGGTCGCCCAGATACAATTACGCCAGCGAAGCTAGAAGTGTTAAATAAATGGAATATTGACCGTATTA
GTATTAATCCGCAGTCATACCATCAAGAAACATTAAAAGCAATTGGGCGTCACCATACTGTAGAAGAAACAATTGAGAAG
TACCACTTAGCTCGTGAAATGGGAATGAACAATATTAATATGGACTTAATTATTGGTCTTCCTGGTGAAGGGTTAGATAT
CTTCAAGCACACATTAGATGAAACAGAAAAGTTAATGCCAGAATCGTTAACAGTTCATACGTTATCATTTAAACGCGCTT
CTGAAATGACGCAAAACAAACGTAAATATAAAGTAGCAGGTCGCGAAGAAATTACAGCGATGATGCACGAAGCAGAAGAG
TGGACGCAAAAGCATAATTACGTACCATATTACCTATACCGTCAAAAGAATATTTTAGGTAACTTAGAGAACGTTGGTTA
CGCAATGCCGACGCAAGAAAGTATTTACAACATTGTCATTATGGAAGAAGTACAATCGATTATCGGACTTGGCTGTGGTG
CATCAAGTAAATTTGTTCATCCGAAGACAGGTGCAATTACGCACTTTGCTAATCCGAAAGATCCAAAATCATATAACGAT
GGCTTCGTAAAATATACAGAAGACAAACTGAAAATTTTAGAAGAGCTATTTGCATAA

Upstream 100 bases:

>100_bases
TTCAGTTTGTTTTAAATAGGATATTAAAATAAGGTAAAACCTTCTGTATTGACCTGCAAACGCCCTTCAAGTAAACTAAA
GAGAGTTTGCAAATGAAAAG

Downstream 100 bases:

>100_bases
GAAGAAAGGAGCTGTTCCGAGTCGGGACAGCTTCTTTTTTATCTTGTCAGTTTTTGTCGGTAAGTCGATATATTCGAAAA
ATCGCTGATATAATTCAAGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MIMLLISIKTLQDDRFLRPLQNISGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTD
EKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQ
LAVVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVTVTTIYYGGGTPT
SITAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEK
YHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEE
WTQKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYND
GFVKYTEDKLKILEELFA

Sequences:

>Translated_498_residues
MIMLLISIKTLQDDRFLRPLQNISGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTD
EKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQ
LAVVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVTVTTIYYGGGTPT
SITAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEK
YHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEE
WTQKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYND
GFVKYTEDKLKILEELFA
>Mature_498_residues
MIMLLISIKTLQDDRFLRPLQNISGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTD
EKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQ
LAVVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVTVTTIYYGGGTPT
SITAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEK
YHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEE
WTQKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYND
GFVKYTEDKLKILEELFA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=302, Percent_Identity=24.1721854304636, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1789325, Length=322, Percent_Identity=26.3975155279503, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082341, Length=192, Percent_Identity=28.125, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 56935; Mature: 56935

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMLLISIKTLQDDRFLRPLQNISGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTD
CEEEEEEEEHHCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEE
VATGNVYEETFAKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTK
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHH
LLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
PFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVTVTTIYYGGGTPT
CCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
SITAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSY
CCCHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHH
HQETLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMP
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
ESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILG
CCEEEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHC
NLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYND
CHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
GFVKYTEDKLKILEELFA
CCEEECHHHHHHHHHHHC
>Mature Secondary Structure
MIMLLISIKTLQDDRFLRPLQNISGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTD
CEEEEEEEEHHCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEE
VATGNVYEETFAKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTK
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHH
LLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
PFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVTVTTIYYGGGTPT
CCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
SITAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSY
CCCHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHH
HQETLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMP
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
ESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILG
CCEEEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHC
NLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYND
CHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
GFVKYTEDKLKILEELFA
CCEEECHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]