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The map label for this gene is yheH [H]

Identifier: 49183834

GI number: 49183834

Start: 861434

End: 862684

Strand: Direct

Name: yheH [H]

Synonym: BAS0810

Alternate gene names: 49183834

Gene position: 861434-862684 (Clockwise)

Preceding gene: 49183833

Following gene: 49183835

Centisome position: 16.48

GC content: 37.49

Gene sequence:

>1251_bases
ATGAGCGTTTCAAAACGATTGTTTCAATACGCAATGAAAGTAAAAGGAACAATTTTTGCAGCGATGCTAATGTTATTTAT
TTTCGTCATCGCAGAGCTTGCTGGTCCTTTCGTCGCGAAAACGATGATTGACGATCATATCGTTGGAATAGAGAAACCTT
GGTATGAAACAGAAAAGAGTGAAGAGGCTGTTTCGTATAATGGAGCCTTTTATAAGAGAAGTGATCGCTTTGAACAAGGT
GAGAAAAAAGGAAAAGAAGTACGCGTGATGCAAGTCGGTTTTCAATATTACTTTGTGCCGAATAAAGTGAATGCTGAAGG
ATCACGTACTGTAAAAGGTGATATGATTACCGTTCAAAATGGTAAGGCGGTGCAAGTGTATAAAGCGAAAGCATTAACGA
AAGAAGAAGTGTTTGCGTTTTATAAACCAGAAATAAACCGACTATTATTACTTGGTGGAGGCTACTTTGCTTTATTAGTA
GTCGTTTCATTGTTTGCATATGGAAAGCAGTTTTTCTTGCAAAAAGCGGCGAACAAAATTATTCAAATTATGAGGGAAGA
TGTCTTTTCTCATATCCAAACGTTGCCGATTCGGTATTTTGATCATTTACCGGCGGGGAAAATTGTTTCGCGCGTGACGA
ATGATACGGAAGCCATTCGTGATCTATACGTAACGGTACTTGCGACATTCGTTTCTAGTATCATCTATATTATTGGGATA
TTTGCCGCGCTATTTTTACTCGATGTAAAATTGGCGACGTTATGTTTGCTTATTATCCCGATTTTAATTGTTTGGGCCAT
TTTATATAGAAAATATGCGTCTGTATACAACCATAAAATGCGTTCGCGTTTATCTGATATTAACGGAACAGTGAATGAAT
CCATTCAAGGGATGCCAATTATTCAAGCGTTCCGTCAAGAACGTGAAACGAAAAAAGAGTTTGAAGAATTAAATGGCGAT
TATTTTAAGTATCAAAATAAAATTTTAAATTTAAATGCAGCTACTTCTCATAATTTAGTAGCCGTATTAAGAAATATTGC
TTTTACAGGTGTGATCTGGTATTTCGGTGGTGCTTCATTAAGTGCTACAGGCGTTATTTCGCTAGGGATACTGTATGCGT
TCGTTGATTATTTAACACGATTGTTCTCACCGATTACAAATATGGTGAATCAGCTTGCTAACTTAGAACAATCGCGCGTT
GCATCCGAGCGCGTTTTCGAACTGTTAGAGGAAAAGGGGGAGAGACAGTAG

Upstream 100 bases:

>100_bases
AAGGTACGCATGATCAGCTTATCCAAAAGGGAGGCTGGTATGCGGAGCAGTTTGAAAGACAACAAGGTGAAAGTGAAAGT
GCGGATAGTGGGGTGAAAAT

Downstream 100 bases:

>100_bases
AAGAAGAGCGTATGCCTCGCTTACAAGGAAATGTGAAGTTTGATAATGTGTCATTTTCTTATAATGGAAAAGATGAAGTG
TTAAAAAATATTTCATTTGA

Product: ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSVSKRLFQYAMKVKGTIFAAMLMLFIFVIAELAGPFVAKTMIDDHIVGIEKPWYETEKSEEAVSYNGAFYKRSDRFEQG
EKKGKEVRVMQVGFQYYFVPNKVNAEGSRTVKGDMITVQNGKAVQVYKAKALTKEEVFAFYKPEINRLLLLGGGYFALLV
VVSLFAYGKQFFLQKAANKIIQIMREDVFSHIQTLPIRYFDHLPAGKIVSRVTNDTEAIRDLYVTVLATFVSSIIYIIGI
FAALFLLDVKLATLCLLIIPILIVWAILYRKYASVYNHKMRSRLSDINGTVNESIQGMPIIQAFRQERETKKEFEELNGD
YFKYQNKILNLNAATSHNLVAVLRNIAFTGVIWYFGGASLSATGVISLGILYAFVDYLTRLFSPITNMVNQLANLEQSRV
ASERVFELLEEKGERQ

Sequences:

>Translated_416_residues
MSVSKRLFQYAMKVKGTIFAAMLMLFIFVIAELAGPFVAKTMIDDHIVGIEKPWYETEKSEEAVSYNGAFYKRSDRFEQG
EKKGKEVRVMQVGFQYYFVPNKVNAEGSRTVKGDMITVQNGKAVQVYKAKALTKEEVFAFYKPEINRLLLLGGGYFALLV
VVSLFAYGKQFFLQKAANKIIQIMREDVFSHIQTLPIRYFDHLPAGKIVSRVTNDTEAIRDLYVTVLATFVSSIIYIIGI
FAALFLLDVKLATLCLLIIPILIVWAILYRKYASVYNHKMRSRLSDINGTVNESIQGMPIIQAFRQERETKKEFEELNGD
YFKYQNKILNLNAATSHNLVAVLRNIAFTGVIWYFGGASLSATGVISLGILYAFVDYLTRLFSPITNMVNQLANLEQSRV
ASERVFELLEEKGERQ
>Mature_415_residues
SVSKRLFQYAMKVKGTIFAAMLMLFIFVIAELAGPFVAKTMIDDHIVGIEKPWYETEKSEEAVSYNGAFYKRSDRFEQGE
KKGKEVRVMQVGFQYYFVPNKVNAEGSRTVKGDMITVQNGKAVQVYKAKALTKEEVFAFYKPEINRLLLLGGGYFALLVV
VSLFAYGKQFFLQKAANKIIQIMREDVFSHIQTLPIRYFDHLPAGKIVSRVTNDTEAIRDLYVTVLATFVSSIIYIIGIF
AALFLLDVKLATLCLLIIPILIVWAILYRKYASVYNHKMRSRLSDINGTVNESIQGMPIIQAFRQERETKKEFEELNGDY
FKYQNKILNLNAATSHNLVAVLRNIAFTGVIWYFGGASLSATGVISLGILYAFVDYLTRLFSPITNMVNQLANLEQSRVA
SERVFELLEEKGERQ

Specific function: Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9955966, Length=234, Percent_Identity=22.6495726495727, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI45243524, Length=234, Percent_Identity=22.6495726495727, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786654, Length=266, Percent_Identity=35.7142857142857, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1787143, Length=263, Percent_Identity=19.3916349809886, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17543740, Length=244, Percent_Identity=23.3606557377049, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 47304; Mature: 47173

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSKRLFQYAMKVKGTIFAAMLMLFIFVIAELAGPFVAKTMIDDHIVGIEKPWYETEKS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
EEAVSYNGAFYKRSDRFEQGEKKGKEVRVMQVGFQYYFVPNKVNAEGSRTVKGDMITVQN
CHHHHCCCCCEECCHHHHHHHHCCCEEEEEEECEEEEECCCCCCCCCCCEEECCEEEECC
GKAVQVYKAKALTKEEVFAFYKPEINRLLLLGGGYFALLVVVSLFAYGKQFFLQKAANKI
CCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQIMREDVFSHIQTLPIRYFDHLPAGKIVSRVTNDTEAIRDLYVTVLATFVSSIIYIIGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FAALFLLDVKLATLCLLIIPILIVWAILYRKYASVYNHKMRSRLSDINGTVNESIQGMPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
IQAFRQERETKKEFEELNGDYFKYQNKILNLNAATSHNLVAVLRNIAFTGVIWYFGGASL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SATGVISLGILYAFVDYLTRLFSPITNMVNQLANLEQSRVASERVFELLEEKGERQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVSKRLFQYAMKVKGTIFAAMLMLFIFVIAELAGPFVAKTMIDDHIVGIEKPWYETEKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
EEAVSYNGAFYKRSDRFEQGEKKGKEVRVMQVGFQYYFVPNKVNAEGSRTVKGDMITVQN
CHHHHCCCCCEECCHHHHHHHHCCCEEEEEEECEEEEECCCCCCCCCCCEEECCEEEECC
GKAVQVYKAKALTKEEVFAFYKPEINRLLLLGGGYFALLVVVSLFAYGKQFFLQKAANKI
CCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQIMREDVFSHIQTLPIRYFDHLPAGKIVSRVTNDTEAIRDLYVTVLATFVSSIIYIIGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FAALFLLDVKLATLCLLIIPILIVWAILYRKYASVYNHKMRSRLSDINGTVNESIQGMPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
IQAFRQERETKKEFEELNGDYFKYQNKILNLNAATSHNLVAVLRNIAFTGVIWYFGGASL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SATGVISLGILYAFVDYLTRLFSPITNMVNQLANLEQSRVASERVFELLEEKGERQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]