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The map label for this gene is cdr [H]

Identifier: 49183760

GI number: 49183760

Start: 791700

End: 793364

Strand: Direct

Name: cdr [H]

Synonym: BAS0736

Alternate gene names: 49183760

Gene position: 791700-793364 (Clockwise)

Preceding gene: 49183759

Following gene: 49183761

Centisome position: 15.14

GC content: 37.96

Gene sequence:

>1665_bases
ATGTCCAGAAAAATAGTTGTAGTAGGCGGAGTTGCGGGCGGGGCCTCAGTAGCTGCAAGGCTTCGTCGATTAAGTGAAGA
AGATGAAATTATTATGGTGGAGCGCGGTGAATATATTTCATTCGCAAATTGTGGATTACCATACTATATTGGCGGTGTCA
TTACAGAAAGACAAAAGTTATTAGTACAAACTGTTGAAAGAATGTCGAAGCGTTTTAATTTAGATATACGTGTATTGAGT
GAAGTAGTAAAGATTAATAAAGAAGAAAAAACAATTACGATAAAGAATGTAACGACAAATGAAACATATAACGAGGCATA
CGATGTGTTAATTCTTTCACCAGGGGCAAAACCAATTGTTCCATCTATTCCAGGGATTGAAGAAGCGAAAGCACTGTTTA
CGTTACGAAATGTACCGGATACTGATCGTATTAAAGCGTATATTGATGAGAAGAAACCACGTCATGCGACGGTGATTGGT
GGCGGATTTATTGGAGTGGAAATGGTTGAAAACTTAAGAGAACGTGGAATTGAGGTTACTCTTGTAGAGATGGCGAATCA
AGTAATGCCACCAATCGATTATGAAATGGCAGCATATGTGCATGAGCATATGAAAAATCACGATGTTGAGCTCGTTTTTG
AAGATGGTGTAGATGCGTTAGAAGAGAACGGGGCTGTTGTACGTTTAAAAAGTGGCTCAGTTATACAAACAGATATGCTT
ATTTTAGCAATTGGTGTACAACCAGAGAGTAGTTTAGCGAAGGGTGCAGGGTTAGCACTAGGAGTTAGAGGAACGATAAA
GGTAAATGAGAAATTTCAAACGTCTGACCCACATATATATGCAATTGGTGATGCGATTGAAGTAAAAGATTTTGTTACTG
AAACAGAAACGATGATTCCTTTAGCGTGGCCGGCTAATCGTCAAGGTCGTATGTTAGCAGATATTATTCATGGTCATACG
GATTCTTTATATAAAGGTACGCTCGGAACTTCTGTAGCTAAAGTTTTTGATCTAACAGTTGCTACGACTGGATTAAATGA
GAAAATATTAAAACGATTAAATATACCCTATGAGGTAGTACATGTGCAGGCAAATTCTCATGCGGGATACTACCCGAATG
CTACGCCAGTGCTAATAAAATTAATTTTTAATAAAGATAGCGGAAAAATTTATGGGGCACAGACGTTAGGACGTGACGGT
GTAGATAAGCGTATGGATGTTATCGCAACGGCAATAAAAGCAAATTTAACTGTACTTGATTTGCCAGATTTAGAATTATC
ATATGCCCCGCCATATTCTTCTGCAAAAGACCCAGTAAACATGGTAGGGTATGCAGCAAGTAATATAGTAGATGGTTTTG
TGGACACAGTACAATGGCATGAGATAGATCGTATTGTTGAAAATGGTGGATATCTTATTGATGTTCGAGAGCCTAATGAA
CTAAAGCAAGGAATGATTAAAGGCTCTATTAATATTCCGTTAGATGAATTACGTGATCGTTTGGAGGAAGTGCCAGTAGA
TAAAGATATATACATTACGTGTCAACTCGGTATGAGAGGGTATGTTGCAGCACGCATGTTAATGGAAAAAGGATATAAGG
TAAAGAATGTAGATGGTGGTTTTAAATTGTATGGGACAGTCTTACCAGAACGTATTGTATATTGA

Upstream 100 bases:

>100_bases
ATTAAATTTTTTATAATTTATTATATACCCATACAGGTATATGTTTTTCGTATGTGATACATGAGAAAATTAAATAATAA
ATAATATGGAGGTTTAAAAT

Downstream 100 bases:

>100_bases
TATTTTTTCATCTTCCACTTCAAAATTTGGTGGAAGATGAAAGCCTATAGATGAAGGTTTCGCTTTGTGTTTTGTGAATG
TATAAAATAAAATTTTAAAA

Product: pyridine nucleotide-disulfide oxidoreductase, class I

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVKINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIG
GGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLKSGSVIQTDML
ILAIGVQPESSLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
DSLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLEEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY

Sequences:

>Translated_554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVKINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIG
GGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLKSGSVIQTDML
ILAIGVQPESSLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
DSLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLEEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY
>Mature_553_residues
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLSE
VVKINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIGG
GFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLKSGSVIQTDMLI
LAIGVQPESSLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHTD
SLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDGV
DKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNEL
KQGMIKGSINIPLDELRDRLEEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=311, Percent_Identity=25.7234726688103, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI65787454, Length=311, Percent_Identity=25.7234726688103, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226437568, Length=311, Percent_Identity=25.7234726688103, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789065, Length=332, Percent_Identity=25.9036144578313, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI87082354, Length=294, Percent_Identity=26.8707482993197, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786307, Length=304, Percent_Identity=28.2894736842105, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789765, Length=289, Percent_Identity=25.9515570934256, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788892, Length=196, Percent_Identity=28.0612244897959, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787352, Length=240, Percent_Identity=26.25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=218, Percent_Identity=26.1467889908257, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585130, Length=293, Percent_Identity=24.9146757679181, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358499, Length=263, Percent_Identity=30.7984790874525, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 61191; Mature: 61060

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVKINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIGGGFIGVEMVENLRERGIEVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
LVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLKSGSVIQTDML
EEHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHCCCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGHTDSLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEVV
EECCCCCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHEEEEEECCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLEEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIVY
EEEEEECCCHHHCC
>Mature Secondary Structure 
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVKINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIGGGFIGVEMVENLRERGIEVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
LVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLKSGSVIQTDML
EEHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHCCCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGHTDSLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEVV
EECCCCCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHEEEEEECCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLEEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIVY
EEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA