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The map label for this gene is kbl [C]

Identifier: 49183611

GI number: 49183611

Start: 634182

End: 635372

Strand: Direct

Name: kbl [C]

Synonym: BAS0586

Alternate gene names: 49183611

Gene position: 634182-635372 (Clockwise)

Preceding gene: 49183609

Following gene: 49183612

Centisome position: 12.13

GC content: 36.69

Gene sequence:

>1191_bases
ATGTCTAGTAAAACACTTGCGAAATTTTTAGAAGAAAATTTAGAGGATTTAAAATCAAAGGGGCTTTATAACGTAATTGA
TCCGCTTGAAAGTTCAAATGGACCGATCATTACAATTGGCGGAAAAGAATATATTAACTTATCTTCAAACAACTATCTTG
GATTAGCAACAGATAGCCGTTTGCAAGAAGCAGCAATTGGTGCAATTCATAAGTACGGCGTTGGAGCAGGAGCGGTTCGT
ACAATTAACGGTACTTTAGATTTGCATATTAAATTAGAAGAAACAATTGCAAAGTTTAAACATACAGAAGCAGCGATTGC
TTATCAATCAGGATTTAATTGTAATATGGCAGCGATTTCAGCCGTTATGGATAAAAATGATGCGATTCTTTCAGACGAGT
TAAACCATGCTTCTATTATTGATGGTAGTCGTCTATCAAAAGCAAAAATTATTGTTTATAAACATTCTGATATGGAAGAT
TTACGCCAAAAAGCAATCGCGGCGAAAGAATCAGGTCTTTACAATAAATTAATGGTAATTACAGACGGTGTCTTTTCAAT
GGATGGAGATGTTGCAAAACTACCAGAAATTGTTGAGATTGCGGAAGAATTAGATTTAATGACATACGTAGACGATGCAC
ACGGTTCAGGTGTACTTGGAAAAGGTGCAGGAACGGTAAAGCACTTCGGTCTGTCTGATAAAGTTGATTTCCAAATTGGT
ACATTATCAAAAGCAATTGGGGTAATTGGTGGATATGTAGCAGGGAAACAAAACTTAATTGACTGGTTAAAAGTTCGTTC
ACGTCCATTCTTATTCTCTACAGCAGTAACGCCAGCTGATGCAGCGGCTTGCATGAGATCAATTGAAATCTTAATGGAAA
GCACAGAGTTGCACGATCGTTTATGGGAAAATGGTCGCTATTTAAAACAAGGGTTAAAAGAACTTGGCTTTAACATCGGA
GAAAGTGAAACGCCAATTACACCTTGTATTATTGGTGACGAAGTATTAACACAAGAATTTAGTAAACGTCTAAATGAAGA
AGGCGTATATGCAAAATCTATCGTGTTCCCAACTGTAGCTAAAGGAACCGGACGCGTTCGTAATATGCCAACAGCAGCTC
ATACGAAAGAAATGTTAGATGAAGCAATTCGTAAGTATGAAAAAGTAGGGAAAGAAATGGGCATCATTTAA

Upstream 100 bases:

>100_bases
TTTTTCTATAATAAATTCTGAAAACGTGTTAAGCTAGTAGAGGGATTATTAGAACTATTAAGACAATAATTCGCTTACAT
GAACGATGGGAGGCTTCACG

Downstream 100 bases:

>100_bases
GTAACGACATCTTTTGAATAGCTTGCAAATGAGGAGTGGGGAAAATGAAAAAAATTCTAGTAACCGGTTCTTTAGGGCAA
ATTGGTTCAGAACTAGTAAT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase 1; 7-keto-8-amino-pelargonic acid synthase 1; 7-KAP synthase 1; KAPA synthase 1; 8-amino-7-ketopelargonate synthase 1; Alpha-oxoamine synthase 1; L-alanine--pimeloyl-CoA ligase 1

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSSKTLAKFLEENLEDLKSKGLYNVIDPLESSNGPIITIGGKEYINLSSNNYLGLATDSRLQEAAIGAIHKYGVGAGAVR
TINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKNDAILSDELNHASIIDGSRLSKAKIIVYKHSDMED
LRQKAIAAKESGLYNKLMVITDGVFSMDGDVAKLPEIVEIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADAAACMRSIEILMESTELHDRLWENGRYLKQGLKELGFNIG
ESETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVAKGTGRVRNMPTAAHTKEMLDEAIRKYEKVGKEMGII

Sequences:

>Translated_396_residues
MSSKTLAKFLEENLEDLKSKGLYNVIDPLESSNGPIITIGGKEYINLSSNNYLGLATDSRLQEAAIGAIHKYGVGAGAVR
TINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKNDAILSDELNHASIIDGSRLSKAKIIVYKHSDMED
LRQKAIAAKESGLYNKLMVITDGVFSMDGDVAKLPEIVEIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADAAACMRSIEILMESTELHDRLWENGRYLKQGLKELGFNIG
ESETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVAKGTGRVRNMPTAAHTKEMLDEAIRKYEKVGKEMGII
>Mature_395_residues
SSKTLAKFLEENLEDLKSKGLYNVIDPLESSNGPIITIGGKEYINLSSNNYLGLATDSRLQEAAIGAIHKYGVGAGAVRT
INGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKNDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDL
RQKAIAAKESGLYNKLMVITDGVFSMDGDVAKLPEIVEIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIGT
LSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADAAACMRSIEILMESTELHDRLWENGRYLKQGLKELGFNIGE
SETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVAKGTGRVRNMPTAAHTKEMLDEAIRKYEKVGKEMGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=35.1898734177215, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=36.1581920903955, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4758668, Length=421, Percent_Identity=33.4916864608076, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI119220554, Length=419, Percent_Identity=31.0262529832936, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=29.0140845070423, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=29.0140845070423, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=29.0140845070423, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=29.5285359801489, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=29.5285359801489, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI5454084, Length=314, Percent_Identity=29.6178343949045, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=38.7179487179487, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=31.9327731092437, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=393, Percent_Identity=37.6590330788804, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=32.520325203252, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17560912, Length=355, Percent_Identity=32.9577464788732, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=355, Percent_Identity=32.9577464788732, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71982617, Length=304, Percent_Identity=28.2894736842105, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=304, Percent_Identity=28.2894736842105, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=390, Percent_Identity=31.5384615384615, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=31.9034852546917, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6323954, Length=259, Percent_Identity=28.1853281853282, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662918, Length=395, Percent_Identity=37.4683544303797, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=34.1954022988506, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17136286, Length=368, Percent_Identity=30.4347826086957, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24653280, Length=291, Percent_Identity=28.1786941580756, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653276, Length=291, Percent_Identity=28.1786941580756, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653278, Length=291, Percent_Identity=28.1786941580756, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB1_BACAN (Q81V80)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843151.1
- RefSeq:   YP_017247.1
- RefSeq:   YP_026863.1
- ProteinModelPortal:   Q81V80
- SMR:   Q81V80
- EnsemblBacteria:   EBBACT00000009491
- EnsemblBacteria:   EBBACT00000014120
- EnsemblBacteria:   EBBACT00000022608
- GeneID:   1087998
- GeneID:   2814953
- GeneID:   2848088
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_0620
- KEGG:   bar:GBAA_0620
- KEGG:   bat:BAS0586
- TIGR:   BA_0620
- TIGR:   GBAA_0620
- GeneTree:   EBGT00050000000589
- HOGENOM:   HBG649839
- OMA:   MELHVEL
- ProtClustDB:   PRK06939
- BioCyc:   BANT260799:BAS0586-MONOMER
- BioCyc:   BANT261594:GBAA0620-MONOMER
- BRENDA:   2.3.1.29
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR13693:SF15
- TIGRFAMs:   TIGR01825

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 43093; Mature: 42962

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 136-136 BINDING 186-186 BINDING 358-358

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKTLAKFLEENLEDLKSKGLYNVIDPLESSNGPIITIGGKEYINLSSNNYLGLATDSR
CCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCEEEEECCCCEEEECCCHH
LQEAAIGAIHKYGVGAGAVRTINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAIS
HHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEHHHHHHHHHHHHHEEECCCCCCCHHHHH
AVMDKNDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDLRQKAIAAKESGLYNKLMVI
HHHCCCCCEECCCCCCCEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHEEEEE
TDGVFSMDGDVAKLPEIVEIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
ECCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCEECCCCCCCCEEHH
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADAAACMRSIEILMESTELHDR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LWENGRYLKQGLKELGFNIGESETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVA
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEHHEECCHHC
KGTGRVRNMPTAAHTKEMLDEAIRKYEKVGKEMGII
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSKTLAKFLEENLEDLKSKGLYNVIDPLESSNGPIITIGGKEYINLSSNNYLGLATDSR
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCEEEEECCCCEEEECCCHH
LQEAAIGAIHKYGVGAGAVRTINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAIS
HHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEHHHHHHHHHHHHHEEECCCCCCCHHHHH
AVMDKNDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDLRQKAIAAKESGLYNKLMVI
HHHCCCCCEECCCCCCCEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHEEEEE
TDGVFSMDGDVAKLPEIVEIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
ECCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCEECCCCCCCCEEHH
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADAAACMRSIEILMESTELHDR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LWENGRYLKQGLKELGFNIGESETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVA
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEHHEECCHHC
KGTGRVRNMPTAAHTKEMLDEAIRKYEKVGKEMGII
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629