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The map label for this gene is npr [H]

Identifier: 49183592

GI number: 49183592

Start: 613632

End: 615332

Strand: Direct

Name: npr [H]

Synonym: BAS0567

Alternate gene names: 49183592

Gene position: 613632-615332 (Clockwise)

Preceding gene: 49183591

Following gene: 49183594

Centisome position: 11.74

GC content: 38.1

Gene sequence:

>1701_bases
ATGAAAAAGAAAAGTTTAGCGTTAGTGTTAGCGACAGGAATGGCAGTTACAACGTTTGGAGGGACAGGCTCTGCTTTTGC
AGATTCTAAAAATGTGCTCTCTACGAAGAAGTACAATGAGACAGTACAGTCACCGGAGTTTATTTCTGGGGATTTAACTG
AAGCAACTGGTAAGAAAGCAGAATCTGTTGTGTTTGATTACTTAAATGCAGCAAAAGGTGATTATAAGTTAGGGGAAAAG
AGTGCGCAAGATTCTTTCAAAGTGAAACAAGCGAAGAAAGATGCTGTAACTGATTCAACAGTATTACGTTTGCAACAAGT
TTACGAAGGAGTACCTGTATGGGGTTCTACGCAAGTAGCTCACGTAAGTAAAGATGGTTCATTAAAAGTATTGTCTGGAA
CAGTTGCACCTGATTTAGACAAAAAAGAAAAGTTGAAAAATAAAAATAAGATCGAAGGCGCAAAAGCAATTGAAATTGCG
CAAAAAGATTTAGGTGTTACACCTAAATATGAGGTAGAACCAAAAGCGGACTTATATGTATATCAAAATGGTGAAGAAAC
AACATATGCATACGTTGTAAATTTAAACTTCTTAGAGCCAAGCCCAGGAAACTACTACTATTTCATTGAAGCGGACAGCG
GTAAAGTATTAAATAAATATAATAAATTGGATCATGTAGCAAATGAAGATAAGTCACCAGTTAAGCAAGAGGCACCTAAA
CAAGAAGCGAAACCGGCTGTAAAGCCTGTAACAGGCACAAATGCAGTGGGTACTGGTAAAGGTGTATTAGGAGATACGAA
GTCACTTAATACAACGTTATCTGCATCATCTTACTATTTACAAGATAATACGCGCGGAGCAACGATTTTCACATATGATG
CGAAAAACCGCTCAACATTACCAGGAACGTTATGGGTAGATGCGGATAATGTTTTCAATGCAGCGTATGATGCAGCGGCA
GTAGATGCTCACTACTATGCTGGTAGAACATATGATTACTATAAAGCGACATTTAATAGAAACTCTATTAATGATGCAGG
AGCACCATTAAAATCAACAGTTCATTATGGAAGTAGATATAATAATGCGTTCTGGAATGGCTCTCAAATGGTATACGGAG
ATGGTGATGGTGTAACATTCACTTCATTGTCTGGTGGAATTGATGTAATTGGCCATGAATTAACGCATGCTGTTACAGAG
TATAGCTCAGATTTAATTTATCAAAATGAATCAGGAGCATTAAATGAAGCTATTTCAGATGTATTTGGTACATTAGTAGA
GTATTATGATAACCGTAACCCTGATTGGGAAATTGGTGAAGATATTTACACGCCTGGTAAAGCTGGAGATGCACTTCGCT
CTATGAGTGATCCAACGAAATATGGTGATCCAGATCATTATTCTAAGCGTTACACAGGTACTGGTGATAACGGTGGCGTT
CATACAAATAGCGGTATTATTAACAAAGCGGCTTACTTACTAGCGAATGGTGGTACGCATTACGGTGTTACTGTAAACGG
TATTGGTAAAGATAAAGTAGGAGCGATTTATTACCGTGCAAATACGCAATATTTCACACAATCTACTACGTTTAGTCAAG
CTCGTGCTGGATTAGTACAAGCTGCAGCTGACTTATATGGTGCTAGCTCTGCAGAAGTAGCAGCAGTTAAGCAATCATAT
AGTGCTGTTGGCGTAAACTAA

Upstream 100 bases:

>100_bases
GAGAAATAAATTAATTGAATTTTTAGTATATTAATAGTGAAAACATAATGCTAATATGAAACTACTCTTTTTCAAAAAAA
AATTATTAGGGGGAAGGTTC

Downstream 100 bases:

>100_bases
GGCTTTAAGGGATAGTTATAATAAAATACCTCAAAAATAAAGAAGGAGCATAGGCTCCTTCTTTATTTTTTTCTCCATTT
TTTCCACAAATAAAACAACC

Product: neutral protease

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTEATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQAKKDAVTDSTVLRLQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QKDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLEPSPGNYYYFIEADSGKVLNKYNKLDHVANEDKSPVKQEAPK
QEAKPAVKPVTGTNAVGTGKGVLGDTKSLNTTLSASSYYLQDNTRGATIFTYDAKNRSTLPGTLWVDADNVFNAAYDAAA
VDAHYYAGRTYDYYKATFNRNSINDAGAPLKSTVHYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
YSSDLIYQNESGALNEAISDVFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGTGDNGGV
HTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSY
SAVGVN

Sequences:

>Translated_566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTEATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQAKKDAVTDSTVLRLQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QKDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLEPSPGNYYYFIEADSGKVLNKYNKLDHVANEDKSPVKQEAPK
QEAKPAVKPVTGTNAVGTGKGVLGDTKSLNTTLSASSYYLQDNTRGATIFTYDAKNRSTLPGTLWVDADNVFNAAYDAAA
VDAHYYAGRTYDYYKATFNRNSINDAGAPLKSTVHYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
YSSDLIYQNESGALNEAISDVFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGTGDNGGV
HTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSY
SAVGVN
>Mature_566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTEATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQAKKDAVTDSTVLRLQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QKDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLEPSPGNYYYFIEADSGKVLNKYNKLDHVANEDKSPVKQEAPK
QEAKPAVKPVTGTNAVGTGKGVLGDTKSLNTTLSASSYYLQDNTRGATIFTYDAKNRSTLPGTLWVDADNVFNAAYDAAA
VDAHYYAGRTYDYYKATFNRNSINDAGAPLKSTVHYGSRYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
YSSDLIYQNESGALNEAISDVFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGTGDNGGV
HTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGASSAEVAAVKQSY
SAVGVN

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 61005; Mature: 61005

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTEATGKKA
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCHH
ESVVFDYLNAAKGDYKLGEKSAQDSFKVKQAKKDAVTDSTVLRLQQVYEGVPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIAQKDLGVTPKYEVEPKADLYV
EECCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
YQNGEETTYAYVVNLNFLEPSPGNYYYFIEADSGKVLNKYNKLDHVANEDKSPVKQEAPK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHCCH
QEAKPAVKPVTGTNAVGTGKGVLGDTKSLNTTLSASSYYLQDNTRGATIFTYDAKNRSTL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCC
PGTLWVDADNVFNAAYDAAAVDAHYYAGRTYDYYKATFNRNSINDAGAPLKSTVHYGSRY
CEEEEEECCHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCC
NNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISD
CCCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
VFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGTGDNGGV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCE
HTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQ
ECCCCCHHCEEEEEECCCEEEEEEEECCCCCCCEEEEEEECCEEEECCCCHHHHHHHHHH
AAADLYGASSAEVAAVKQSYSAVGVN
HHHHHHCCCCCHHHHHHHCCHHCCCC
>Mature Secondary Structure
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTEATGKKA
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCHH
ESVVFDYLNAAKGDYKLGEKSAQDSFKVKQAKKDAVTDSTVLRLQQVYEGVPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIAQKDLGVTPKYEVEPKADLYV
EECCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
YQNGEETTYAYVVNLNFLEPSPGNYYYFIEADSGKVLNKYNKLDHVANEDKSPVKQEAPK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHCCH
QEAKPAVKPVTGTNAVGTGKGVLGDTKSLNTTLSASSYYLQDNTRGATIFTYDAKNRSTL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCC
PGTLWVDADNVFNAAYDAAAVDAHYYAGRTYDYYKATFNRNSINDAGAPLKSTVHYGSRY
CEEEEEECCHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCC
NNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSDLIYQNESGALNEAISD
CCCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
VFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGTGDNGGV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCE
HTNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQ
ECCCCCHHCEEEEEECCCEEEEEEEECCCCCCCEEEEEEECCEEEECCCCHHHHHHHHHH
AAADLYGASSAEVAAVKQSYSAVGVN
HHHHHHCCCCCHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1495388; 3092843; 3127592; 1633827 [H]