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The map label for this gene is dnaA

Identifier: 47525234

GI number: 47525234

Start: 30

End: 1367

Strand: Direct

Name: dnaA

Synonym: GSU0000.1

Alternate gene names: 47525234

Gene position: 30-1367 (Clockwise)

Preceding gene: NA

Following gene: 39995112

Centisome position: 0.0

GC content: 54.33

Gene sequence:

>1338_bases
ATGGAAGAAGTTTGGCTCCAGGCACAATCCAATCTCGCTAAGGTTCTCACACATCAGACCTTTAACACCTGGATCGAACC
GATCAAGTATCTCGGATCCAAGAAGAATGTGCTGCTGCTGGAAGCCCCGAACCAGTTCGTCAGGGACCGGGTAAGCGAAA
GCTATCTTCCCATGATTCTCGAATCGGTTCAATCGCTTACCGATTCCCAGACCAAGATCGAACTTCTGATCGCAAAGCCC
AAAACGGAAAAACCCAAACAGCCTGCGGCCTCTGAGGTCACCGCCGCGGAACCGGAAGCCTGTTCGGGGCCCGATCACTC
AACCAACCTGAACCCCAAGTACACCTTCGACACGTTCGTCTGCGGCGGCAGCAACCAGTTCGCTCACGCGGCGGCCCAGT
CGGTGGCGAACAGCCCGGCCGGCAAGTACAATCCCCTTTTCATATACGGTGGCGTGGGACTGGGTAAAACCCACCTCCTC
AACGCAATCGGCAACCATGTGCTGTCGGTGAACCGCAAGGCACGGATCTGTTTCTACACGTCGGAAAAATTCATGAACGA
ACTCATCAACTGCCTGCGGTACCAGAAGATGGATCAGTTCAGAAACAAGTTCCGTAAGATGGACATTCTTCTCATCGACG
ACATCCAGTTCATCGCCGGCAAGGAACGGACCCAGGAGGAGTTTTTCCACACCTTCAACTCGCTCTACGAATCCCACAAG
CAGATCGTAGTGACGTCCGACAAGTTCCCCAAGGATATTCCCGGCCTGGAAGAGCGCCTCCGCTCACGTTTCGAGTGGGG
CCTCATCGCCGATATCCAGGCGCCCGACACGGAAACCAAGGTAGCGATCCTGCGCAAGAAGGCGGATGCGGACCATATCT
CGCTCCCCGACGATGTGGCCCTGTTTCTGGCATCCAGCTCAACAACCAACGTGCGGGAACTGGAAGGAATGCTCATCAGA
CTCGGTGCCGTTTCGAGCCTGACCGGCAAGAACATCACCCTCGACATGGCACGGGAAGTCCTCAAGGACATCATTGTGGA
CAAGTCGAAGGAAATAACGGTTGAGATGATCCAGAAATTCGTGGCCGAACACTTCAGCCTCAAGGTGGCTGATCTCAAAT
CGGACAAGCGGCTCAAGGCGCTGGTGATACCACGCCAGATTGCCATATTCCTGTGCCGTGATCTTACCAAATCTTCATAT
CCGGAGATCGGTGAACGGTTCGGCGGCAAAGATCATTCAACCATCATCCACTCGGTGAAAAAGGTGGAAAAGCTCCTCAG
TCAGGATTTCGAACTCAGAAACACCGTCGACACCCTGAGGAAGGGGCTGTTGAGCTGA

Upstream 100 bases:

>100_bases
GTTGTTGAAAAACCTGTGTATAACTAATAAGTTTCACTATCTCCCGGCGAGTACGGGTTCTGAGCGACTGAGCTTCGCGT
TTCCCGAGAAGGTCTGGTTT

Downstream 100 bases:

>100_bases
GAGGCAACAACCCTGTGGACAGAGGAACAGTTATCTACATGCCGTTGTCCCTGTCCGAGGACGTCCGTGGATAACCAACG
CCGTGCCCACAGGACGGCAT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MEEVWLQAQSNLAKVLTHQTFNTWIEPIKYLGSKKNVLLLEAPNQFVRDRVSESYLPMILESVQSLTDSQTKIELLIAKP
KTEKPKQPAASEVTAAEPEACSGPDHSTNLNPKYTFDTFVCGGSNQFAHAAAQSVANSPAGKYNPLFIYGGVGLGKTHLL
NAIGNHVLSVNRKARICFYTSEKFMNELINCLRYQKMDQFRNKFRKMDILLIDDIQFIAGKERTQEEFFHTFNSLYESHK
QIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQAPDTETKVAILRKKADADHISLPDDVALFLASSSTTNVRELEGMLIR
LGAVSSLTGKNITLDMAREVLKDIIVDKSKEITVEMIQKFVAEHFSLKVADLKSDKRLKALVIPRQIAIFLCRDLTKSSY
PEIGERFGGKDHSTIIHSVKKVEKLLSQDFELRNTVDTLRKGLLS

Sequences:

>Translated_445_residues
MEEVWLQAQSNLAKVLTHQTFNTWIEPIKYLGSKKNVLLLEAPNQFVRDRVSESYLPMILESVQSLTDSQTKIELLIAKP
KTEKPKQPAASEVTAAEPEACSGPDHSTNLNPKYTFDTFVCGGSNQFAHAAAQSVANSPAGKYNPLFIYGGVGLGKTHLL
NAIGNHVLSVNRKARICFYTSEKFMNELINCLRYQKMDQFRNKFRKMDILLIDDIQFIAGKERTQEEFFHTFNSLYESHK
QIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQAPDTETKVAILRKKADADHISLPDDVALFLASSSTTNVRELEGMLIR
LGAVSSLTGKNITLDMAREVLKDIIVDKSKEITVEMIQKFVAEHFSLKVADLKSDKRLKALVIPRQIAIFLCRDLTKSSY
PEIGERFGGKDHSTIIHSVKKVEKLLSQDFELRNTVDTLRKGLLS
>Mature_445_residues
MEEVWLQAQSNLAKVLTHQTFNTWIEPIKYLGSKKNVLLLEAPNQFVRDRVSESYLPMILESVQSLTDSQTKIELLIAKP
KTEKPKQPAASEVTAAEPEACSGPDHSTNLNPKYTFDTFVCGGSNQFAHAAAQSVANSPAGKYNPLFIYGGVGLGKTHLL
NAIGNHVLSVNRKARICFYTSEKFMNELINCLRYQKMDQFRNKFRKMDILLIDDIQFIAGKERTQEEFFHTFNSLYESHK
QIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQAPDTETKVAILRKKADADHISLPDDVALFLASSSTTNVRELEGMLIR
LGAVSSLTGKNITLDMAREVLKDIIVDKSKEITVEMIQKFVAEHFSLKVADLKSDKRLKALVIPRQIAIFLCRDLTKSSY
PEIGERFGGKDHSTIIHSVKKVEKLLSQDFELRNTVDTLRKGLLS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=43.8709677419355, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI226510964, Length=233, Percent_Identity=27.0386266094421, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_GEOSL (Q74GG6)

Other databases:

- EMBL:   AE017180
- RefSeq:   YP_016331.1
- ProteinModelPortal:   Q74GG6
- GeneID:   2808007
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0000.1
- TIGR:   GSU0000.1
- HOGENOM:   HBG695666
- OMA:   TRINDEM
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50191; Mature: 50191

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVWLQAQSNLAKVLTHQTFNTWIEPIKYLGSKKNVLLLEAPNQFVRDRVSESYLPMIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ESVQSLTDSQTKIELLIAKPKTEKPKQPAASEVTAAEPEACSGPDHSTNLNPKYTFDTFV
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
CGGSNQFAHAAAQSVANSPAGKYNPLFIYGGVGLGKTHLLNAIGNHVLSVNRKARICFYT
ECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHEECCCCEEEEEEE
SEKFMNELINCLRYQKMDQFRNKFRKMDILLIDDIQFIAGKERTQEEFFHTFNSLYESHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCC
QIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQAPDTETKVAILRKKADADHISLPDDVA
EEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHE
LFLASSSTTNVRELEGMLIRLGAVSSLTGKNITLDMAREVLKDIIVDKSKEITVEMIQKF
EEEECCCCCHHHHHHHHHHHHCCHHCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHH
VAEHFSLKVADLKSDKRLKALVIPRQIAIFLCRDLTKSSYPEIGERFGGKDHSTIIHSVK
HHHHHCEEEECCCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHH
KVEKLLSQDFELRNTVDTLRKGLLS
HHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEVWLQAQSNLAKVLTHQTFNTWIEPIKYLGSKKNVLLLEAPNQFVRDRVSESYLPMIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ESVQSLTDSQTKIELLIAKPKTEKPKQPAASEVTAAEPEACSGPDHSTNLNPKYTFDTFV
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
CGGSNQFAHAAAQSVANSPAGKYNPLFIYGGVGLGKTHLLNAIGNHVLSVNRKARICFYT
ECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHEECCCCEEEEEEE
SEKFMNELINCLRYQKMDQFRNKFRKMDILLIDDIQFIAGKERTQEEFFHTFNSLYESHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCC
QIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQAPDTETKVAILRKKADADHISLPDDVA
EEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHE
LFLASSSTTNVRELEGMLIRLGAVSSLTGKNITLDMAREVLKDIIVDKSKEITVEMIQKF
EEEECCCCCHHHHHHHHHHHHCCHHCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHH
VAEHFSLKVADLKSDKRLKALVIPRQIAIFLCRDLTKSSYPEIGERFGGKDHSTIIHSVK
HHHHHCEEEECCCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHH
KVEKLLSQDFELRNTVDTLRKGLLS
HHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA