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The map label for this gene is phoR [H]

Identifier: 46447515

GI number: 46447515

Start: 2241946

End: 2243715

Strand: Direct

Name: phoR [H]

Synonym: pc1881

Alternate gene names: 46447515

Gene position: 2241946-2243715 (Clockwise)

Preceding gene: 46447514

Following gene: 46447516

Centisome position: 92.85

GC content: 33.79

Gene sequence:

>1770_bases
ATGTTTAGTTTCCGACAAAAAATTTTTATTAGCTATGTATTTGTCTTTTGTATCTTCATTATTCCTTTGTTTCCTTTAGT
TTCTCATTGGGTTCATCGAATTATCGTCAAAGGGATGGAAAATCGTGCTTCGGAAATTATAGCTCATATTCAAGATGCTC
CTAATAAAGAGACTTTAATCAAACGCTTAAAAGATCAAAAGAGTAATATTTTCTTTCGCATGGGAATTATCAGTGAAGAA
AGTAAAGTATTATACGATTCTCACGTTAAACGTATTCTAGGGCCTAAGTTTCATCAGAATTATGTCCTAGATCATCCTGA
AGTTCGTGAAGCATTTGATTGCGGATTAGGTTTTCACGAAGCATATTCCAAAATTCTTCAGCAAAAGTTTACTTATTTTG
CTAAATCGTTTGGTTATCAGAATAAAACATACGTTTTGAGAACCGCCTTTCCTCAGCAATATGTCGATGAAATGACTCGA
GATTTTGAAATTGGTTTCTTGGTATTTGCAACTGCGATTTTACTTTTATTTAGCATGATCACATGGATTGCCATGAATCA
TTTAACAAAACCTATTCAAAAAATCATCCAATCAGCTAGATCTTATCAAATGGGAGGCCAACAAAGCTTTTCAGAGATAG
ATACAAGTAATTTAAATCCTAAAGATGATTTTACAAAATTAGCTCTTACTCTCAATAGCCTATCAGCAAAAATTAGAAAT
CATATTCATATTTTAACGCAAGAGCGAGATGAGAAAGAAGCCATCTTAGAATCACTTGTGGAAGGAGTAATTGCCGTTGA
CCGTACAATGTGTATCGCTTATGCAAATCACATGGCAATCAAATTTATTGGATTAAATCAACTTGATTTAATAGGTCAAA
AATTTTCTTCTCTAAACCAAGAAAAATACTTAACACTATTAAGACAATGTCAAGAAGAAGAAAAACCTTTAACAGACACT
CTAGAAATAAATATTGAGGGGAAAAAACTTTACCTTGATATTGTTGCGGCTCCCAAAAGGAATAACAGTGGAGCAATACT
TGTTCTACAAGATAAAACAGCGCACTATAAAATATTCGAAATGCGAAGAGATTTTATTGCTAACGCTTCCCATGAATTAA
AAACACCTATTACTATTATCCGTGGATTTGCTGAAGCACTTTACGATAATCCGGGGCTACCTCAAGATATTCAAAATGAA
ATTACCACTAAAATTGTCCGTAACTGTAAGCGCATGACGGCTCTCATTAAAGATTTATTAACCTTAGCAGATATTGAGAA
CATTCCTTCTTCTCGCTTAAGCTTATGTGATCTTTTTGATTTAACAACTCGTTGTCAATCTATGCTTCATGAAATATTTC
CTGATGCCGAAGTGAATATCGAAACGTCAAGCGATGACATTAAATTAATAGTAGATGAAGATTTATTCGAATTAGCGATC
ATGAACTTGATTGAAAATGCTGCGAAATATTCTTCGAGGCCGGCGCATATTTTTGTCAAATTAAACGATTTATCCGATCA
TATTGTGATTGAAGTTTCTGATCAAGGTATCGGCATTCCGCTTGCCGATCAAGAGCATATTTTTGATCGTTTTTACACGG
TAGATAAAGCTCACTCTCAAAAAATGGGAGGATCAGGCCTTGGACTTTCTATCGTTAAAACAATTATTGAAAAACACTTT
GGTACAATTACCTTAAAATCTGAACTAGGTAAAGGATCGACTTTCACGATTACCCTTCCTAAATCAATTCGTCCAGAAGT
GGAATTCTAA

Upstream 100 bases:

>100_bases
TTAACCCAATCTTAACTAACTAACAGCAAATTATTTACTTTTTCTTAATTAAAATAGTTGTTACAATTTTTATTAAATAA
AAAAAGTTCCTGGCTTAAAC

Downstream 100 bases:

>100_bases
AGATTTTATTTACCGAAAATAGTGAGATTTCCCACAATGCGAGAAAACACTTGATAGGGAGATTTGATGACTAATGATGT
TCGCTTAACTTCAGATTTAA

Product: putative two-component sensor histidine kinase phoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MFSFRQKIFISYVFVFCIFIIPLFPLVSHWVHRIIVKGMENRASEIIAHIQDAPNKETLIKRLKDQKSNIFFRMGIISEE
SKVLYDSHVKRILGPKFHQNYVLDHPEVREAFDCGLGFHEAYSKILQQKFTYFAKSFGYQNKTYVLRTAFPQQYVDEMTR
DFEIGFLVFATAILLLFSMITWIAMNHLTKPIQKIIQSARSYQMGGQQSFSEIDTSNLNPKDDFTKLALTLNSLSAKIRN
HIHILTQERDEKEAILESLVEGVIAVDRTMCIAYANHMAIKFIGLNQLDLIGQKFSSLNQEKYLTLLRQCQEEEKPLTDT
LEINIEGKKLYLDIVAAPKRNNSGAILVLQDKTAHYKIFEMRRDFIANASHELKTPITIIRGFAEALYDNPGLPQDIQNE
ITTKIVRNCKRMTALIKDLLTLADIENIPSSRLSLCDLFDLTTRCQSMLHEIFPDAEVNIETSSDDIKLIVDEDLFELAI
MNLIENAAKYSSRPAHIFVKLNDLSDHIVIEVSDQGIGIPLADQEHIFDRFYTVDKAHSQKMGGSGLGLSIVKTIIEKHF
GTITLKSELGKGSTFTITLPKSIRPEVEF

Sequences:

>Translated_589_residues
MFSFRQKIFISYVFVFCIFIIPLFPLVSHWVHRIIVKGMENRASEIIAHIQDAPNKETLIKRLKDQKSNIFFRMGIISEE
SKVLYDSHVKRILGPKFHQNYVLDHPEVREAFDCGLGFHEAYSKILQQKFTYFAKSFGYQNKTYVLRTAFPQQYVDEMTR
DFEIGFLVFATAILLLFSMITWIAMNHLTKPIQKIIQSARSYQMGGQQSFSEIDTSNLNPKDDFTKLALTLNSLSAKIRN
HIHILTQERDEKEAILESLVEGVIAVDRTMCIAYANHMAIKFIGLNQLDLIGQKFSSLNQEKYLTLLRQCQEEEKPLTDT
LEINIEGKKLYLDIVAAPKRNNSGAILVLQDKTAHYKIFEMRRDFIANASHELKTPITIIRGFAEALYDNPGLPQDIQNE
ITTKIVRNCKRMTALIKDLLTLADIENIPSSRLSLCDLFDLTTRCQSMLHEIFPDAEVNIETSSDDIKLIVDEDLFELAI
MNLIENAAKYSSRPAHIFVKLNDLSDHIVIEVSDQGIGIPLADQEHIFDRFYTVDKAHSQKMGGSGLGLSIVKTIIEKHF
GTITLKSELGKGSTFTITLPKSIRPEVEF
>Mature_589_residues
MFSFRQKIFISYVFVFCIFIIPLFPLVSHWVHRIIVKGMENRASEIIAHIQDAPNKETLIKRLKDQKSNIFFRMGIISEE
SKVLYDSHVKRILGPKFHQNYVLDHPEVREAFDCGLGFHEAYSKILQQKFTYFAKSFGYQNKTYVLRTAFPQQYVDEMTR
DFEIGFLVFATAILLLFSMITWIAMNHLTKPIQKIIQSARSYQMGGQQSFSEIDTSNLNPKDDFTKLALTLNSLSAKIRN
HIHILTQERDEKEAILESLVEGVIAVDRTMCIAYANHMAIKFIGLNQLDLIGQKFSSLNQEKYLTLLRQCQEEEKPLTDT
LEINIEGKKLYLDIVAAPKRNNSGAILVLQDKTAHYKIFEMRRDFIANASHELKTPITIIRGFAEALYDNPGLPQDIQNE
ITTKIVRNCKRMTALIKDLLTLADIENIPSSRLSLCDLFDLTTRCQSMLHEIFPDAEVNIETSSDDIKLIVDEDLFELAI
MNLIENAAKYSSRPAHIFVKLNDLSDHIVIEVSDQGIGIPLADQEHIFDRFYTVDKAHSQKMGGSGLGLSIVKTIIEKHF
GTITLKSELGKGSTFTITLPKSIRPEVEF

Specific function: Member of the two-component regulatory system resD/resE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates resD [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=334, Percent_Identity=28.7425149700599, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788549, Length=383, Percent_Identity=25.8485639686684, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=31.9327731092437, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790861, Length=203, Percent_Identity=29.5566502463054, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=29.3859649122807, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=28.82096069869, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=30.8016877637131, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=28.9915966386555, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=26.1603375527426, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=26.9709543568465, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI145693157, Length=277, Percent_Identity=27.4368231046931, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=29.5964125560538, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=30.9322033898305, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790300, Length=356, Percent_Identity=26.123595505618, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=27.8008298755187, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=26.3829787234043, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=29.9145299145299, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787374, Length=220, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=219, Percent_Identity=27.8538812785388, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=82, Percent_Identity=43.9024390243902, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67341; Mature: 67341

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSFRQKIFISYVFVFCIFIIPLFPLVSHWVHRIIVKGMENRASEIIAHIQDAPNKETLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KRLKDQKSNIFFRMGIISEESKVLYDSHVKRILGPKFHQNYVLDHPEVREAFDCGLGFHE
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHH
AYSKILQQKFTYFAKSFGYQNKTYVLRTAFPQQYVDEMTRDFEIGFLVFATAILLLFSMI
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TWIAMNHLTKPIQKIIQSARSYQMGGQQSFSEIDTSNLNPKDDFTKLALTLNSLSAKIRN
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HIHILTQERDEKEAILESLVEGVIAVDRTMCIAYANHMAIKFIGLNQLDLIGQKFSSLNQ
HEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCH
EKYLTLLRQCQEEEKPLTDTLEINIEGKKLYLDIVAAPKRNNSGAILVLQDKTAHYKIFE
HHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHH
MRRDFIANASHELKTPITIIRGFAEALYDNPGLPQDIQNEITTKIVRNCKRMTALIKDLL
HHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLADIENIPSSRLSLCDLFDLTTRCQSMLHEIFPDAEVNIETSSDDIKLIVDEDLFELAI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHH
MNLIENAAKYSSRPAHIFVKLNDLSDHIVIEVSDQGIGIPLADQEHIFDRFYTVDKAHSQ
HHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KMGGSGLGLSIVKTIIEKHFGTITLKSELGKGSTFTITLPKSIRPEVEF
CCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MFSFRQKIFISYVFVFCIFIIPLFPLVSHWVHRIIVKGMENRASEIIAHIQDAPNKETLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KRLKDQKSNIFFRMGIISEESKVLYDSHVKRILGPKFHQNYVLDHPEVREAFDCGLGFHE
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHH
AYSKILQQKFTYFAKSFGYQNKTYVLRTAFPQQYVDEMTRDFEIGFLVFATAILLLFSMI
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TWIAMNHLTKPIQKIIQSARSYQMGGQQSFSEIDTSNLNPKDDFTKLALTLNSLSAKIRN
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HIHILTQERDEKEAILESLVEGVIAVDRTMCIAYANHMAIKFIGLNQLDLIGQKFSSLNQ
HEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCH
EKYLTLLRQCQEEEKPLTDTLEINIEGKKLYLDIVAAPKRNNSGAILVLQDKTAHYKIFE
HHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHH
MRRDFIANASHELKTPITIIRGFAEALYDNPGLPQDIQNEITTKIVRNCKRMTALIKDLL
HHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLADIENIPSSRLSLCDLFDLTTRCQSMLHEIFPDAEVNIETSSDDIKLIVDEDLFELAI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHH
MNLIENAAKYSSRPAHIFVKLNDLSDHIVIEVSDQGIGIPLADQEHIFDRFYTVDKAHSQ
HHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KMGGSGLGLSIVKTIIEKHFGTITLKSELGKGSTFTITLPKSIRPEVEF
CCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715 [H]