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The map label for this gene is rnr [H]

Identifier: 46447205

GI number: 46447205

Start: 1885398

End: 1886966

Strand: Direct

Name: rnr [H]

Synonym: pc1571

Alternate gene names: 46447205

Gene position: 1885398-1886966 (Clockwise)

Preceding gene: 46447199

Following gene: 46447206

Centisome position: 78.09

GC content: 33.84

Gene sequence:

>1569_bases
TTGGCAGTTTCAAAAAATCATTTTCCCATTTCACTTGTGTATAAATCATCAACCACATTAAAAAACATAGAAAGATTAAC
ATATCCATTCAATAGGATTTTTATGGCAATTCAAGAGCTCAAACCGACTTTTGACTTAACAGAAATCGCCAAAAAAACAA
TGCGCGAAAAAAATCTTCTGACGGAATTTTTACTGGATGTCCAAAAAGCGACAGAAAAAACTTTCGACCATGGTGCCATT
TCCCCCGCTACAAAAAGAATGACAGATTTTCTTTGGTGTTCAATTGATAACGATGATTCAAAGTATCTAGATCAGTTAAC
ATATGCGGAAAAATTGGATGATGAAACGTATAAAATCTATATTGCTATTGCTGAAGTCGATCACCTTGTTCCTCAAAATT
CTGTCATTGATAGACATGCCCAATATAATACTGTCTCGATTTATACTCCTACAAAAGTTTTTCCAATGCTTCCTGAGAAA
CTATCGGCAGGTTTAACTTCTTTAAATGAAGGTGTAGATCGCTTAGCGATAGTGGTTGAAGTTGAAGTTAATGATAATGG
AGCTTTAGGAAACTTCAACATTTATTCAGCTCTTGTACACAATCATGCTAAGCTCGCTTATAATAGTGTATCGACATGGT
TAGAAGGAAATGGGCCTATCCCAGAAAAAGTTGCCAATGTAACAGGAATGGAAGCACAATTGTATCTTCAAGATACTATT
ACTCAACTTTTAAAAGAGTTTCGAAATCAAAAAGGAGCATTAGCCTTAGAGACGATTAAACCAAAAACTATCGTTGAAAA
GGAAGATGCTATTGATATTAAAATTTCTAAAAAAAATCGAGCCCGGGATTTAATTGAAAATTTTATGATTGTAGCCAACA
CAATCACAGCTCTTTATTTAAAATCTAAACAACTCCCTTCATTTCGCAAAATAGTCAGGGTACCAAAAAAGTGGGATCGT
ATTGTAGAAATTGCACGCGACCTTGGTGAAACATTGCCAGATCAACCAGACTCCAAAGCTTTAGATTTATTCTTAATTAA
ACAAAAATTATTAGATCCTGTCCATTTCCCTGATTTATCGCTGACAATTATTAAGCTTCTTGGAAATGGAGAATATATCG
TTGAATATTATGATGATATGCCGATTGGTCATTTTGGTTTAGCTCATGCTGATTATACACATTCTACAGCTCCTAATCGT
CGATATCTCGATTTAATTACACAAAGAATCATTAAAGCTGCTTTGGAAAATAAAGAAATGCCTTACACTTTAAATGAACT
TGAAAAATTGGCTAAACATTGCACAATTCAAGAAGTCGAAGCTGATAAAGTAGAGCGTAAAATGAGAAAATCAGCAGCCA
TGATGCTTTTATTTTCTAAATTTGGTGAAGTTTTTGATGCGATCATCACAGGAGCTGGAACTAAAGGAACTTGGGTACAC
ATTTTTAATCCCTCTGTTGACGGGAAATTAGTTGGTGGATTTGAAAATAAGGATGTAGGCGATTTAATTTTAGTTAAGCT
TATCCATTTAGATATTGAAAATGGGCATATTGATTTTACAAAGGTATAA

Upstream 100 bases:

>100_bases
TAAACGCTGAGGATAACGATGAATAAAATTTTGAGAAGGATCAGTTCGATGTAATACCCTTTCATTCATTGAATCTCTCC
ATTCCTTACATAATTATGCT

Downstream 100 bases:

>100_bases
GTTTTAGTAATTCGCTTGACTTTGTAAAAGTTAAATTTTTTAGTTCACTTGTGAATAAAGTCCGCTCTGAATTAAAATAA
GTGTACCGTGCTTTTTTCTT

Product: putative ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAVSKNHFPISLVYKSSTTLKNIERLTYPFNRIFMAIQELKPTFDLTEIAKKTMREKNLLTEFLLDVQKATEKTFDHGAI
SPATKRMTDFLWCSIDNDDSKYLDQLTYAEKLDDETYKIYIAIAEVDHLVPQNSVIDRHAQYNTVSIYTPTKVFPMLPEK
LSAGLTSLNEGVDRLAIVVEVEVNDNGALGNFNIYSALVHNHAKLAYNSVSTWLEGNGPIPEKVANVTGMEAQLYLQDTI
TQLLKEFRNQKGALALETIKPKTIVEKEDAIDIKISKKNRARDLIENFMIVANTITALYLKSKQLPSFRKIVRVPKKWDR
IVEIARDLGETLPDQPDSKALDLFLIKQKLLDPVHFPDLSLTIIKLLGNGEYIVEYYDDMPIGHFGLAHADYTHSTAPNR
RYLDLITQRIIKAALENKEMPYTLNELEKLAKHCTIQEVEADKVERKMRKSAAMMLLFSKFGEVFDAIITGAGTKGTWVH
IFNPSVDGKLVGGFENKDVGDLILVKLIHLDIENGHIDFTKV

Sequences:

>Translated_522_residues
MAVSKNHFPISLVYKSSTTLKNIERLTYPFNRIFMAIQELKPTFDLTEIAKKTMREKNLLTEFLLDVQKATEKTFDHGAI
SPATKRMTDFLWCSIDNDDSKYLDQLTYAEKLDDETYKIYIAIAEVDHLVPQNSVIDRHAQYNTVSIYTPTKVFPMLPEK
LSAGLTSLNEGVDRLAIVVEVEVNDNGALGNFNIYSALVHNHAKLAYNSVSTWLEGNGPIPEKVANVTGMEAQLYLQDTI
TQLLKEFRNQKGALALETIKPKTIVEKEDAIDIKISKKNRARDLIENFMIVANTITALYLKSKQLPSFRKIVRVPKKWDR
IVEIARDLGETLPDQPDSKALDLFLIKQKLLDPVHFPDLSLTIIKLLGNGEYIVEYYDDMPIGHFGLAHADYTHSTAPNR
RYLDLITQRIIKAALENKEMPYTLNELEKLAKHCTIQEVEADKVERKMRKSAAMMLLFSKFGEVFDAIITGAGTKGTWVH
IFNPSVDGKLVGGFENKDVGDLILVKLIHLDIENGHIDFTKV
>Mature_521_residues
AVSKNHFPISLVYKSSTTLKNIERLTYPFNRIFMAIQELKPTFDLTEIAKKTMREKNLLTEFLLDVQKATEKTFDHGAIS
PATKRMTDFLWCSIDNDDSKYLDQLTYAEKLDDETYKIYIAIAEVDHLVPQNSVIDRHAQYNTVSIYTPTKVFPMLPEKL
SAGLTSLNEGVDRLAIVVEVEVNDNGALGNFNIYSALVHNHAKLAYNSVSTWLEGNGPIPEKVANVTGMEAQLYLQDTIT
QLLKEFRNQKGALALETIKPKTIVEKEDAIDIKISKKNRARDLIENFMIVANTITALYLKSKQLPSFRKIVRVPKKWDRI
VEIARDLGETLPDQPDSKALDLFLIKQKLLDPVHFPDLSLTIIKLLGNGEYIVEYYDDMPIGHFGLAHADYTHSTAPNRR
YLDLITQRIIKAALENKEMPYTLNELEKLAKHCTIQEVEADKVERKMRKSAAMMLLFSKFGEVFDAIITGAGTKGTWVHI
FNPSVDGKLVGGFENKDVGDLILVKLIHLDIENGHIDFTKV

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=355, Percent_Identity=24.2253521126761, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI190014623, Length=387, Percent_Identity=24.031007751938, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI134288890, Length=375, Percent_Identity=25.6, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082383, Length=469, Percent_Identity=28.1449893390192, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1787542, Length=384, Percent_Identity=25.78125, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17553506, Length=404, Percent_Identity=25.990099009901, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645896, Length=419, Percent_Identity=22.1957040572792, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324552, Length=386, Percent_Identity=27.2020725388601, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24649634, Length=367, Percent_Identity=22.6158038147139, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24654592, Length=369, Percent_Identity=27.10027100271, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922976, Length=369, Percent_Identity=27.10027100271, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24654597, Length=369, Percent_Identity=27.10027100271, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 59189; Mature: 59058

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSKNHFPISLVYKSSTTLKNIERLTYPFNRIFMAIQELKPTFDLTEIAKKTMREKNLL
CCCCCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TEFLLDVQKATEKTFDHGAISPATKRMTDFLWCSIDNDDSKYLDQLTYAEKLDDETYKIY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
IAIAEVDHLVPQNSVIDRHAQYNTVSIYTPTKVFPMLPEKLSAGLTSLNEGVDRLAIVVE
EEEEHHHHHCCCCCHHHHCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHCCCCEEEEEEE
VEVNDNGALGNFNIYSALVHNHAKLAYNSVSTWLEGNGPIPEKVANVTGMEAQLYLQDTI
EEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEHHHHHH
TQLLKEFRNQKGALALETIKPKTIVEKEDAIDIKISKKNRARDLIENFMIVANTITALYL
HHHHHHHHCCCCCEEEEECCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
KSKQLPSFRKIVRVPKKWDRIVEIARDLGETLPDQPDSKALDLFLIKQKLLDPVHFPDLS
HCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
LTIIKLLGNGEYIVEYYDDMPIGHFGLAHADYTHSTAPNRRYLDLITQRIIKAALENKEM
EEHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
PYTLNELEKLAKHCTIQEVEADKVERKMRKSAAMMLLFSKFGEVFDAIITGAGTKGTWVH
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IFNPSVDGKLVGGFENKDVGDLILVKLIHLDIENGHIDFTKV
EECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCEEEEEEC
>Mature Secondary Structure 
AVSKNHFPISLVYKSSTTLKNIERLTYPFNRIFMAIQELKPTFDLTEIAKKTMREKNLL
CCCCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TEFLLDVQKATEKTFDHGAISPATKRMTDFLWCSIDNDDSKYLDQLTYAEKLDDETYKIY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
IAIAEVDHLVPQNSVIDRHAQYNTVSIYTPTKVFPMLPEKLSAGLTSLNEGVDRLAIVVE
EEEEHHHHHCCCCCHHHHCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHCCCCEEEEEEE
VEVNDNGALGNFNIYSALVHNHAKLAYNSVSTWLEGNGPIPEKVANVTGMEAQLYLQDTI
EEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEHHHHHH
TQLLKEFRNQKGALALETIKPKTIVEKEDAIDIKISKKNRARDLIENFMIVANTITALYL
HHHHHHHHCCCCCEEEEECCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
KSKQLPSFRKIVRVPKKWDRIVEIARDLGETLPDQPDSKALDLFLIKQKLLDPVHFPDLS
HCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
LTIIKLLGNGEYIVEYYDDMPIGHFGLAHADYTHSTAPNRRYLDLITQRIIKAALENKEM
EEHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
PYTLNELEKLAKHCTIQEVEADKVERKMRKSAAMMLLFSKFGEVFDAIITGAGTKGTWVH
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IFNPSVDGKLVGGFENKDVGDLILVKLIHLDIENGHIDFTKV
EECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]