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The map label for this gene is clpP

Identifier: 46447010

GI number: 46447010

Start: 1650179

End: 1650802

Strand: Direct

Name: clpP

Synonym: pc1376

Alternate gene names: 46447010

Gene position: 1650179-1650802 (Clockwise)

Preceding gene: 46447009

Following gene: 46447011

Centisome position: 68.35

GC content: 38.94

Gene sequence:

>624_bases
ATGTCACACTCTTCTCATCCAAGACCTGAAATGTCTTTAACTCCTTACGTTATTGAAGATACAGGCCGTGGCGAACGTTC
CATGGATATTTACTCTCGTTTACTTAAAGACCGCATTATTTTTATTGGAACTGAAATCACGGATCAAGTAGCAAACGTTG
TTGTAGCTCAACTACTTTTTTTGAAAATGGAAGATCCTAAGAAAGATGTTCATATTTATATTAACTCTTTAGGTGGATAT
ATCACTTCAGGCCTTGCGATCTATGATACTATGCAATACCTTGGATGTGACATCAATACCTATTGTATTGGGCAAGCAGC
CTCGATGGGAGCCTTACTTTTGACTGCCGGAACAAAAGGTAAGCGATTTGCTTTACCAAACAGCCGTATCATGATTCACC
AACCTTATGGTGGTGTCGGTGGAACTTCTGCCGATGTTGCATTGCAAGCTAAAGAAATTCTCGAATTGAAGAAAAGATTA
AATCATATCATGGCTGATAGCACAAGACAGCCTTTAGAAAAAATTGCTGCGGATTCTGAGAGAGATTTTTACATGAGTGC
TGTGGAAGCTAAAGATTATGGCCTAATTGATGAAGTTGTCGTCCCCAAAAAAAAGACAACATGA

Upstream 100 bases:

>100_bases
TTTTATTGTTTGGCAATCATATACATCGTAGATGATTGAACAGTTGTTAAAAACACATTCAATACTTATCTGAAGCTAAT
GATTTTAATTGAGGATTCAT

Downstream 100 bases:

>100_bases
TAGAATTTACCTAGGGTGTATAAAACTGAAAACAAAATTTGATCTTCTTTCTCAAAAGCAAGTTTTAGAAATCCTCAAAC
TTGCTTTAAATAAAAACTCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSHSSHPRPEMSLTPYVIEDTGRGERSMDIYSRLLKDRIIFIGTEITDQVANVVVAQLLFLKMEDPKKDVHIYINSLGGY
ITSGLAIYDTMQYLGCDINTYCIGQAASMGALLLTAGTKGKRFALPNSRIMIHQPYGGVGGTSADVALQAKEILELKKRL
NHIMADSTRQPLEKIAADSERDFYMSAVEAKDYGLIDEVVVPKKKTT

Sequences:

>Translated_207_residues
MSHSSHPRPEMSLTPYVIEDTGRGERSMDIYSRLLKDRIIFIGTEITDQVANVVVAQLLFLKMEDPKKDVHIYINSLGGY
ITSGLAIYDTMQYLGCDINTYCIGQAASMGALLLTAGTKGKRFALPNSRIMIHQPYGGVGGTSADVALQAKEILELKKRL
NHIMADSTRQPLEKIAADSERDFYMSAVEAKDYGLIDEVVVPKKKTT
>Mature_206_residues
SHSSHPRPEMSLTPYVIEDTGRGERSMDIYSRLLKDRIIFIGTEITDQVANVVVAQLLFLKMEDPKKDVHIYINSLGGYI
TSGLAIYDTMQYLGCDINTYCIGQAASMGALLLTAGTKGKRFALPNSRIMIHQPYGGVGGTSADVALQAKEILELKKRLN
HIMADSTRQPLEKIAADSERDFYMSAVEAKDYGLIDEVVVPKKKTT

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=58.1151832460733, Blast_Score=234, Evalue=4e-62,
Organism=Escherichia coli, GI1786641, Length=196, Percent_Identity=57.6530612244898, Blast_Score=251, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=185, Percent_Identity=52.972972972973, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=52.1052631578947, Blast_Score=213, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_PARUW (Q6MBE9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008375.1
- ProteinModelPortal:   Q6MBE9
- SMR:   Q6MBE9
- STRING:   Q6MBE9
- MEROPS:   S14.001
- GeneID:   2779715
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1376
- NMPDR:   fig|264201.1.peg.1376
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   CPRO264201:PC1376-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22904; Mature: 22773

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 108-108 ACT_SITE 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSSHPRPEMSLTPYVIEDTGRGERSMDIYSRLLKDRIIFIGTEITDQVANVVVAQLLF
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHH
LKMEDPKKDVHIYINSLGGYITSGLAIYDTMQYLGCDINTYCIGQAASMGALLLTAGTKG
HHCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCC
KRFALPNSRIMIHQPYGGVGGTSADVALQAKEILELKKRLNHIMADSTRQPLEKIAADSE
CEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
RDFYMSAVEAKDYGLIDEVVVPKKKTT
CCHHHHHHCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SHSSHPRPEMSLTPYVIEDTGRGERSMDIYSRLLKDRIIFIGTEITDQVANVVVAQLLF
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHH
LKMEDPKKDVHIYINSLGGYITSGLAIYDTMQYLGCDINTYCIGQAASMGALLLTAGTKG
HHCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCC
KRFALPNSRIMIHQPYGGVGGTSADVALQAKEILELKKRLNHIMADSTRQPLEKIAADSE
CEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
RDFYMSAVEAKDYGLIDEVVVPKKKTT
CCHHHHHHCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA