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The map label for this gene is lexA [H]

Identifier: 46446903

GI number: 46446903

Start: 1515854

End: 1516465

Strand: Direct

Name: lexA [H]

Synonym: pc1269

Alternate gene names: 46446903

Gene position: 1515854-1516465 (Clockwise)

Preceding gene: 46446902

Following gene: 46446905

Centisome position: 62.78

GC content: 39.05

Gene sequence:

>612_bases
TTGACACCCAAACAACAAGCTATTTTGCAATTTATTCAACAATTTATCGAGACTCATCAATATTCACCGAGTTACAGAGA
GATTATGAAACACTTTTCTCTTGCTTCCCCAGCTTCCGTTCATAAACACATTCAATCTTTGCAACGCAAAGGGGTGCTAG
CAGCCGAAAAAAAATGCAGTCGTTCTCTCATCCCTACTCATCCTCCCGCTTCACTAACTTTTTCAGCTGAAGTGTTACTC
CCTCTTATTGGCAATATCATGGCTGGCTATCCCATTGAGATGTTTATGCGACCCCAAACCATTGCTGTTCCATCCACTTT
TGTACATCATTTAAATAATACTTATATCTTACGCGTTCAGGGTAATAGCCTGTCAGAAGAGCTCATTCAAGACGGAGACC
TTTTGGTTGTTGAAGCAAGATCTATTGTTCAGCCAGGAGAAATTATCATCGGCGCAATTAATCATCATAACACCGTTGTT
AAACGTTATTATCCTGAAGGGCAATACATTCGTTTAGAAAGCATTCATATCAATCATTCCTCTTTAACACTCCGTCACGA
TCACCTAGCTATACAAGGGGTATTAACAAATCTCATACGTTTTTATTGTTAA

Upstream 100 bases:

>100_bases
ACTTTTTTTCTGATGTGGTTTTTTCTGCATTAATTATGTGGTTGACATCGATTGGATGTTATCAAATAATCTTTAAAAGC
GGCTATTCACCATGAAAGGA

Downstream 100 bases:

>100_bases
TTAAATTTCTAAATTCTCCATTGATCAAAAAAACCATTCAAATTGAAATTTGATTCAAATATTATTTGCAAGCATTGTGC
AATATTTATTGTCGAATAAT

Product: putative SOS response regulator lexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MTPKQQAILQFIQQFIETHQYSPSYREIMKHFSLASPASVHKHIQSLQRKGVLAAEKKCSRSLIPTHPPASLTFSAEVLL
PLIGNIMAGYPIEMFMRPQTIAVPSTFVHHLNNTYILRVQGNSLSEELIQDGDLLVVEARSIVQPGEIIIGAINHHNTVV
KRYYPEGQYIRLESIHINHSSLTLRHDHLAIQGVLTNLIRFYC

Sequences:

>Translated_203_residues
MTPKQQAILQFIQQFIETHQYSPSYREIMKHFSLASPASVHKHIQSLQRKGVLAAEKKCSRSLIPTHPPASLTFSAEVLL
PLIGNIMAGYPIEMFMRPQTIAVPSTFVHHLNNTYILRVQGNSLSEELIQDGDLLVVEARSIVQPGEIIIGAINHHNTVV
KRYYPEGQYIRLESIHINHSSLTLRHDHLAIQGVLTNLIRFYC
>Mature_202_residues
TPKQQAILQFIQQFIETHQYSPSYREIMKHFSLASPASVHKHIQSLQRKGVLAAEKKCSRSLIPTHPPASLTFSAEVLLP
LIGNIMAGYPIEMFMRPQTIAVPSTFVHHLNNTYILRVQGNSLSEELIQDGDLLVVEARSIVQPGEIIIGAINHHNTVVK
RYYPEGQYIRLESIHINHSSLTLRHDHLAIQGVLTNLIRFYC

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=204, Percent_Identity=28.921568627451, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23009; Mature: 22878

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKQQAILQFIQQFIETHQYSPSYREIMKHFSLASPASVHKHIQSLQRKGVLAAEKKCS
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHC
RSLIPTHPPASLTFSAEVLLPLIGNIMAGYPIEMFMRPQTIAVPSTFVHHLNNTYILRVQ
CCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCCEEECHHHHHHHCCCEEEEEEE
GNSLSEELIQDGDLLVVEARSIVQPGEIIIGAINHHNTVVKRYYPEGQYIRLESIHINHS
CCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCC
SLTLRHDHLAIQGVLTNLIRFYC
EEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPKQQAILQFIQQFIETHQYSPSYREIMKHFSLASPASVHKHIQSLQRKGVLAAEKKCS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHC
RSLIPTHPPASLTFSAEVLLPLIGNIMAGYPIEMFMRPQTIAVPSTFVHHLNNTYILRVQ
CCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCCEEECHHHHHHHCCCEEEEEEE
GNSLSEELIQDGDLLVVEARSIVQPGEIIIGAINHHNTVVKRYYPEGQYIRLESIHINHS
CCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCC
SLTLRHDHLAIQGVLTNLIRFYC
EEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA