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The map label for this gene is uvrA [H]

Identifier: 46446879

GI number: 46446879

Start: 1483362

End: 1486175

Strand: Direct

Name: uvrA [H]

Synonym: pc1245

Alternate gene names: 46446879

Gene position: 1483362-1486175 (Clockwise)

Preceding gene: 46446866

Following gene: 46446889

Centisome position: 61.44

GC content: 36.74

Gene sequence:

>2814_bases
ATGTCAGTTTTTTCTTACCATAGATTTATTAATTTACAAGGATGTAAAGAACATAATTTAAAAAACTTGTCTGTTCAATT
ACCTAAGCATGCCATCACTGTGATCACAGGAGTAAGCGGATCTGGAAAATCTTCTTTAGCATTTGATACTTTATTTGCCG
AAGGACAACGTCGCTATCTAGAATACCTTTCCCCTCAAGCGCGCCCCTGGATCAAGCAAATGCCTAAGCCTGATGTTGAT
TTGATTGAAGGGTTGTCTCCTACCTTAGCGATTGGACAGCATAGACAACCCCTTTACTTTTATGGGACTGTGGCGACCTA
TACAGATCTTTACGATTTTTTATCGCTCTTATATGCAAAAGTTGGGGATCAATATAGCCCAGCCACCGGCAAAAAATTGT
CCCGTTTCACGCGTCAAGAAATGATTGATTGGATTTTAAAAAATTATTCCGCGGGCTCTCGCTTACAATTAATAGCTCCT
ATCAAATTGGTCAAAGAAAACGGACATCAAGCCATTACACGTCTGCAACAAATGGGCTTTATACGGATGCGAATCAATGA
GCAAGAATGGTGCGGAGAAAACCCTTTTCCAATCAACAAAGCCATTTCAAATTTAGAAGTTGTTGTAGATCGTTTAGAAA
TTAGAGAAGGCATACGTGATCGTTTGGCCCCATCTGTGGAAACTGCTTTAGATTTGAGTCAAGGTATTTTAAAAATCCAA
GAAGGAAAGGAAGGCAATACTCATTATCTAACAGAGATTTATGTATGTCCAGAAACAGGATTTTCTTTTGCACCTTTAGA
AGCTGGGGACTTTAATTTTAATTCTCCAAAAGGAGCTTGCGCAGCTTGCAATGGACTGGGTGGGCGAGAACAAGTCAATC
CCTCTCAAGTTATTTTTGATGAAAACGAACCTTTATTAGATCAAATTCAGGTGATTTTAGATCACCTTCCCAAAAAGGCA
GCTTATTCTTTCAAGTCTCTTTTAAAAGCTTTATGGAAAATTTTAAATCTTTCGGAAGAAAATTTTATCAAAGACATTTC
GCAGATGATTTTAAATAAAATTTTATTTGGTCATTCCCAAGAAATTGTTTTTAACGTTCAGATAAATGAAGAATCAGAAC
AATTAAAAGCGAAATGGAAAGGCCTTATTCCTGTTTTAAACGAAGCCTTGGAAATGAAAAAAAACAAAGGGTCTTTAAGC
GAACTTTCTTTTATTGATTGGCAAACCTGTTCATCTTGTTTAGGAGGAAGACTTAAACCAGAAAGTCTAGCTTGTCTTAT
CCAGGAAAAAAACATCTATCAACTCTGCTCATTAACCGTAGCTGAGTGTTTAATAAAGATTAAAGCATGGTTATTTACCG
GAAAACAAGAGGCCATTGTTAAAGAAATTCTTCCTCATATTCAATCTCGATTAGAATTTCTCGACCAAGTAGGATTGGGA
TACTTGACATTAACTAGAGAAGGGAAAACACTCAGTGATGGAGAAGCTCATCGAATTCAATTAGCATCTCAAATTGGAGC
CAAATTATCCGGAATTATCTACATACTAGATGAACCCTCATTAGGACTGCATCGACAAGATATCCAACATTTGCACAAAG
TCATTCATGAACTAAAAGCCTTGGGTAATACTGTTGTAATTGTTGAACATGAAAAAAGCTTAATTCAACAAGCTGATTAT
ATTTTGGAACTCGGTCCAGGAGCTGGAAGCTTAGGAGGGCAAATTTGTTTTCAAGGAACTATTACAGACCTTCTTAATGA
CTCAAACAGTCTAACCGGAAAATGGCTCAGTGGTAAACTTTCATTACCTATCCCTCCAAGAAGAAAAATTCAACAAGACT
GGTTAGAAATTCGTGGAGCGACTTTAAATAATTTAAATGATTTCTCTGCAAATATTCCATTAGGCTGCTTTGTAGGTTTT
TGTGGAGTGTCCGGATCGGGAAAATCTACCCTTGTTTTAGATATCATTGGACAACAGCTAAAAAATTTTCTAGTAAGAGG
AATAATCCCTCATTTTTTAAATAAATATCAAACAATCAAACGTTTAATCAGCCATGAAAAACAAACAGATCGCTTATCGG
CACGCTCTATTCCAGCTACCTATATAGGTATAATGACTCCACTCAGACAACTTTTTGCCGAAACTCGTCTTGCTAAAGCA
AGAGGCTATACAGCTTCTCGTTTTAGTTTAAATAAGCGAGGTGGAAGATGTGAAGCTTGTGAAGGACTGGGTTATATTGA
AGTGAATATGCACCTTATGCCAGATTTTTTTATGCCTTGTGATATTTGCCAAGGGTTACGCTATAACTATGAAACATTAC
AGATTACATGGGAAAATAAAAATATTGCTGATATTCTACGTCTGTCGGCTTTAGAATCTTTTCAGTTGTTTAAACATATT
CCCTCTCTAGCACCCACCTTAGAACTGATGACAGAGCTTGGTTTAGATTATTTACAGTTGGGACAACCCTTCAATACTTT
ATCCGGAGGAGAAATTCAGCGATTGAAATTGATTGCTGATTTAGCAGGCAAAACACAAGAAAAAACATTATATATTTTGG
ATGAACCTTCGTCCGGTCTTCATTTACAAGACATTGAAAAACTCGTTAAAATTCTTCATAAACTAGTAGAAAAAGGACAC
ACAGTTTTTGTGATTGAACATCATTTAGACATCCTTTACCAAGCAGACTGGCTCATTGAATTAGGTCCGGAAGGAGGGCC
AAAAGGAGGAAGGCTCATTTTTGAGGGCCCTTCAACTAAGATGATCAAAGCCCATACACCAACTGGAAAAGTTTTCTCTC
AGTTTAATCAATGA

Upstream 100 bases:

>100_bases
GCTTAAATGATTGCTTAAAAACCAAGTTATTAATTCACTTGCCTATATCTTTAAATTAACGTGTTTTAAGTGAAATTGCA
ACAAAATTATAAGTATTTAT

Downstream 100 bases:

>100_bases
TAAATAACCTCCTATGATCTCTCAAACATTTTAAAATTCTTTAGTTTATTACACTAATTTCTTCTGTTTTTTTGTTTAAA
TAACTCATAGTATTTTTTTG

Product: putative excinuclease ABC chain A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 937; Mature: 936

Protein sequence:

>937_residues
MSVFSYHRFINLQGCKEHNLKNLSVQLPKHAITVITGVSGSGKSSLAFDTLFAEGQRRYLEYLSPQARPWIKQMPKPDVD
LIEGLSPTLAIGQHRQPLYFYGTVATYTDLYDFLSLLYAKVGDQYSPATGKKLSRFTRQEMIDWILKNYSAGSRLQLIAP
IKLVKENGHQAITRLQQMGFIRMRINEQEWCGENPFPINKAISNLEVVVDRLEIREGIRDRLAPSVETALDLSQGILKIQ
EGKEGNTHYLTEIYVCPETGFSFAPLEAGDFNFNSPKGACAACNGLGGREQVNPSQVIFDENEPLLDQIQVILDHLPKKA
AYSFKSLLKALWKILNLSEENFIKDISQMILNKILFGHSQEIVFNVQINEESEQLKAKWKGLIPVLNEALEMKKNKGSLS
ELSFIDWQTCSSCLGGRLKPESLACLIQEKNIYQLCSLTVAECLIKIKAWLFTGKQEAIVKEILPHIQSRLEFLDQVGLG
YLTLTREGKTLSDGEAHRIQLASQIGAKLSGIIYILDEPSLGLHRQDIQHLHKVIHELKALGNTVVIVEHEKSLIQQADY
ILELGPGAGSLGGQICFQGTITDLLNDSNSLTGKWLSGKLSLPIPPRRKIQQDWLEIRGATLNNLNDFSANIPLGCFVGF
CGVSGSGKSTLVLDIIGQQLKNFLVRGIIPHFLNKYQTIKRLISHEKQTDRLSARSIPATYIGIMTPLRQLFAETRLAKA
RGYTASRFSLNKRGGRCEACEGLGYIEVNMHLMPDFFMPCDICQGLRYNYETLQITWENKNIADILRLSALESFQLFKHI
PSLAPTLELMTELGLDYLQLGQPFNTLSGGEIQRLKLIADLAGKTQEKTLYILDEPSSGLHLQDIEKLVKILHKLVEKGH
TVFVIEHHLDILYQADWLIELGPEGGPKGGRLIFEGPSTKMIKAHTPTGKVFSQFNQ

Sequences:

>Translated_937_residues
MSVFSYHRFINLQGCKEHNLKNLSVQLPKHAITVITGVSGSGKSSLAFDTLFAEGQRRYLEYLSPQARPWIKQMPKPDVD
LIEGLSPTLAIGQHRQPLYFYGTVATYTDLYDFLSLLYAKVGDQYSPATGKKLSRFTRQEMIDWILKNYSAGSRLQLIAP
IKLVKENGHQAITRLQQMGFIRMRINEQEWCGENPFPINKAISNLEVVVDRLEIREGIRDRLAPSVETALDLSQGILKIQ
EGKEGNTHYLTEIYVCPETGFSFAPLEAGDFNFNSPKGACAACNGLGGREQVNPSQVIFDENEPLLDQIQVILDHLPKKA
AYSFKSLLKALWKILNLSEENFIKDISQMILNKILFGHSQEIVFNVQINEESEQLKAKWKGLIPVLNEALEMKKNKGSLS
ELSFIDWQTCSSCLGGRLKPESLACLIQEKNIYQLCSLTVAECLIKIKAWLFTGKQEAIVKEILPHIQSRLEFLDQVGLG
YLTLTREGKTLSDGEAHRIQLASQIGAKLSGIIYILDEPSLGLHRQDIQHLHKVIHELKALGNTVVIVEHEKSLIQQADY
ILELGPGAGSLGGQICFQGTITDLLNDSNSLTGKWLSGKLSLPIPPRRKIQQDWLEIRGATLNNLNDFSANIPLGCFVGF
CGVSGSGKSTLVLDIIGQQLKNFLVRGIIPHFLNKYQTIKRLISHEKQTDRLSARSIPATYIGIMTPLRQLFAETRLAKA
RGYTASRFSLNKRGGRCEACEGLGYIEVNMHLMPDFFMPCDICQGLRYNYETLQITWENKNIADILRLSALESFQLFKHI
PSLAPTLELMTELGLDYLQLGQPFNTLSGGEIQRLKLIADLAGKTQEKTLYILDEPSSGLHLQDIEKLVKILHKLVEKGH
TVFVIEHHLDILYQADWLIELGPEGGPKGGRLIFEGPSTKMIKAHTPTGKVFSQFNQ
>Mature_936_residues
SVFSYHRFINLQGCKEHNLKNLSVQLPKHAITVITGVSGSGKSSLAFDTLFAEGQRRYLEYLSPQARPWIKQMPKPDVDL
IEGLSPTLAIGQHRQPLYFYGTVATYTDLYDFLSLLYAKVGDQYSPATGKKLSRFTRQEMIDWILKNYSAGSRLQLIAPI
KLVKENGHQAITRLQQMGFIRMRINEQEWCGENPFPINKAISNLEVVVDRLEIREGIRDRLAPSVETALDLSQGILKIQE
GKEGNTHYLTEIYVCPETGFSFAPLEAGDFNFNSPKGACAACNGLGGREQVNPSQVIFDENEPLLDQIQVILDHLPKKAA
YSFKSLLKALWKILNLSEENFIKDISQMILNKILFGHSQEIVFNVQINEESEQLKAKWKGLIPVLNEALEMKKNKGSLSE
LSFIDWQTCSSCLGGRLKPESLACLIQEKNIYQLCSLTVAECLIKIKAWLFTGKQEAIVKEILPHIQSRLEFLDQVGLGY
LTLTREGKTLSDGEAHRIQLASQIGAKLSGIIYILDEPSLGLHRQDIQHLHKVIHELKALGNTVVIVEHEKSLIQQADYI
LELGPGAGSLGGQICFQGTITDLLNDSNSLTGKWLSGKLSLPIPPRRKIQQDWLEIRGATLNNLNDFSANIPLGCFVGFC
GVSGSGKSTLVLDIIGQQLKNFLVRGIIPHFLNKYQTIKRLISHEKQTDRLSARSIPATYIGIMTPLRQLFAETRLAKAR
GYTASRFSLNKRGGRCEACEGLGYIEVNMHLMPDFFMPCDICQGLRYNYETLQITWENKNIADILRLSALESFQLFKHIP
SLAPTLELMTELGLDYLQLGQPFNTLSGGEIQRLKLIADLAGKTQEKTLYILDEPSSGLHLQDIEKLVKILHKLVEKGHT
VFVIEHHLDILYQADWLIELGPEGGPKGGRLIFEGPSTKMIKAHTPTGKVFSQFNQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=906, Percent_Identity=38.8520971302428, Blast_Score=645, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 105073; Mature: 104942

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFSYHRFINLQGCKEHNLKNLSVQLPKHAITVITGVSGSGKSSLAFDTLFAEGQRRYL
CCCCCEEEEEEECCCCCCCCCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
EYLSPQARPWIKQMPKPDVDLIEGLSPTLAIGQHRQPLYFYGTVATYTDLYDFLSLLYAK
HHHCCCCCCHHHHCCCCCHHHHHCCCCHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
VGDQYSPATGKKLSRFTRQEMIDWILKNYSAGSRLQLIAPIKLVKENGHQAITRLQQMGF
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHCCE
IRMRINEQEWCGENPFPINKAISNLEVVVDRLEIREGIRDRLAPSVETALDLSQGILKIQ
EEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEE
EGKEGNTHYLTEIYVCPETGFSFAPLEAGDFNFNSPKGACAACNGLGGREQVNPSQVIFD
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEC
ENEPLLDQIQVILDHLPKKAAYSFKSLLKALWKILNLSEENFIKDISQMILNKILFGHSQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
EIVFNVQINEESEQLKAKWKGLIPVLNEALEMKKNKGSLSELSFIDWQTCSSCLGGRLKP
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCCCH
ESLACLIQEKNIYQLCSLTVAECLIKIKAWLFTGKQEAIVKEILPHIQSRLEFLDQVGLG
HHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
YLTLTREGKTLSDGEAHRIQLASQIGAKLSGIIYILDEPSLGLHRQDIQHLHKVIHELKA
EEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGNTVVIVEHEKSLIQQADYILELGPGAGSLGGQICFQGTITDLLNDSNSLTGKWLSGKL
CCCEEEEEECHHHHHHHCCCEEEECCCCCCCCCCEEECCHHHHHHCCCCCCCCEEECCEE
SLPIPPRRKIQQDWLEIRGATLNNLNDFSANIPLGCFVGFCGVSGSGKSTLVLDIIGQQL
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHH
KNFLVRGIIPHFLNKYQTIKRLISHEKQTDRLSARSIPATYIGIMTPLRQLFAETRLAKA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RGYTASRFSLNKRGGRCEACEGLGYIEVNMHLMPDFFMPCDICQGLRYNYETLQITWENK
CCCCCCEEEECCCCCCCCHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCC
NIADILRLSALESFQLFKHIPSLAPTLELMTELGLDYLQLGQPFNTLSGGEIQRLKLIAD
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHH
LAGKTQEKTLYILDEPSSGLHLQDIEKLVKILHKLVEKGHTVFVIEHHLDILYQADWLIE
HCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHEECCEEEE
LGPEGGPKGGRLIFEGPSTKMIKAHTPTGKVFSQFNQ
ECCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHCCC
>Mature Secondary Structure 
SVFSYHRFINLQGCKEHNLKNLSVQLPKHAITVITGVSGSGKSSLAFDTLFAEGQRRYL
CCCCEEEEEEECCCCCCCCCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
EYLSPQARPWIKQMPKPDVDLIEGLSPTLAIGQHRQPLYFYGTVATYTDLYDFLSLLYAK
HHHCCCCCCHHHHCCCCCHHHHHCCCCHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
VGDQYSPATGKKLSRFTRQEMIDWILKNYSAGSRLQLIAPIKLVKENGHQAITRLQQMGF
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHCCE
IRMRINEQEWCGENPFPINKAISNLEVVVDRLEIREGIRDRLAPSVETALDLSQGILKIQ
EEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEE
EGKEGNTHYLTEIYVCPETGFSFAPLEAGDFNFNSPKGACAACNGLGGREQVNPSQVIFD
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEC
ENEPLLDQIQVILDHLPKKAAYSFKSLLKALWKILNLSEENFIKDISQMILNKILFGHSQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
EIVFNVQINEESEQLKAKWKGLIPVLNEALEMKKNKGSLSELSFIDWQTCSSCLGGRLKP
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCCCH
ESLACLIQEKNIYQLCSLTVAECLIKIKAWLFTGKQEAIVKEILPHIQSRLEFLDQVGLG
HHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
YLTLTREGKTLSDGEAHRIQLASQIGAKLSGIIYILDEPSLGLHRQDIQHLHKVIHELKA
EEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGNTVVIVEHEKSLIQQADYILELGPGAGSLGGQICFQGTITDLLNDSNSLTGKWLSGKL
CCCEEEEEECHHHHHHHCCCEEEECCCCCCCCCCEEECCHHHHHHCCCCCCCCEEECCEE
SLPIPPRRKIQQDWLEIRGATLNNLNDFSANIPLGCFVGFCGVSGSGKSTLVLDIIGQQL
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHH
KNFLVRGIIPHFLNKYQTIKRLISHEKQTDRLSARSIPATYIGIMTPLRQLFAETRLAKA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RGYTASRFSLNKRGGRCEACEGLGYIEVNMHLMPDFFMPCDICQGLRYNYETLQITWENK
CCCCCCEEEECCCCCCCCHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEEECCC
NIADILRLSALESFQLFKHIPSLAPTLELMTELGLDYLQLGQPFNTLSGGEIQRLKLIAD
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHH
LAGKTQEKTLYILDEPSSGLHLQDIEKLVKILHKLVEKGHTVFVIEHHLDILYQADWLIE
HCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHEECCEEEE
LGPEGGPKGGRLIFEGPSTKMIKAHTPTGKVFSQFNQ
ECCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]