Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 46446737

GI number: 46446737

Start: 1321975

End: 1323474

Strand: Reverse

Name: pepA

Synonym: pc1103

Alternate gene names: 46446737

Gene position: 1323474-1321975 (Counterclockwise)

Preceding gene: 46446738

Following gene: 46446736

Centisome position: 54.81

GC content: 37.13

Gene sequence:

>1500_bases
ATGGAATTTGCCTTAACTTTACACATTGAAAAAAGAAAAAAAGCTGATGTTTTAGTACTTCCTTTTTGGAAAGGCACATC
TCAGCCAGAAGCAGCGATTGCTTTGCATCCTTTAAAATTATCATTAGATTCTGTGTTTAACACAGGAGATTTTAAGGGAA
AGGAAGGGGAGACCTTATTTTTATATGTAGAAGGATTAGTAGAAATGCGAGTGGCTTTGCTCGGTCTTGGTGAGAAAAAT
AAAGTATCAACCGAAGCTTTAAGAAAAAGCTATGGGTGTCTAGCAAAAGCTTGTTTGGGAAAGAAGTTAAAAACGCTTAA
TATTTTAATGCCTGAGTTTAATAAAACAGAAGAGGATGCATTTATTAAAGCAATAACAGAAGGTCTTTTATTACCTAACT
ACGTTTACGATCGACTGAAAAGTAAGCAAGAAGAGGATGATGAAGTGACTTTATTACAGAAAATTAACTTTATCAGTTCG
AATAAACACGTTTTAGCTCTTGCTGAAGAAGTTGCTGCAATTTGTGATGGTGTTTATTATACGAGAGATTTAATCAATGG
GAATGCGGATGAAATTACTCCTCAATACTTGGCCAAATGTGCCCAGGGTTTATCCCAAGAGTATCCCCAAATTAAGACCA
CCGTGTTTGATAAGAAACGATTGGAAAAAGAGCAAATGGGCCTTCTCCTTGCTGTTAATCGGGGATCAAATTTAGATCCA
ACTTTGATTATTATGGAGTATAAAGGAAATCCTAAATCAAAAGATCATACCGTAATTATTGGAAAAGGAGTTACTTATGA
TACTGGTGGGCTTAATATTAAGCCAACGGGAGGAATAGAAACCATGAAATGCGATATGTCGGGCGGTGCTGCTTGTTTTG
GGACTATGCTAGCTGCCTGTCATTTAGATTTAAAGGTGAATTTAACAGCCATTATTCCAGCAACAGAAAATAGCGTGGAT
GCTGCGAGTTTTAAACCTGGTGATGTTTATCGAAGCTATTTAGGTAAAACTGTTGAAATGACCAATTCAGATGCGGAAGG
ACGTTTAATATTAGCTGACGCCTTAGCTTATGCGAGCCAAAATTTGAAGCCTTCTCGTTTAATTGATATCGCTACATTAA
CAGGTGCTATTGAAATTTCGCTAGGTTCAGAAGCTTCGGGATTGATGAGTACAGATGACCAGTTAGCGAAAAGTTTGATT
CAGGCAGGAGAAAATACACATGAGCGTCTCTGGCGTATGCCTCTTTATGAAGGATATCAAGAAAAACTTAAATCAGATAT
TGCCGATCTTAAAAGTTGGAATGGCCGTTCAGGAAGTTCCTGCGTAGCAGCAATGTTTCTCAAAAATTTTGTTGGAAAAG
ATATTCCTTGGGCACACTTGGATATTGCAGGAACAGCTTATGTGACAGAACCTAAAAAATACATGCCGAAATATGCATCT
GGAGTTGGTGTGAGATTACTTGTGGAGTTTTTAAAGCAGCTTTCAATGGTAAAAAATTAA

Upstream 100 bases:

>100_bases
TAAGAAATGATGCAGGAAAATTCACCTTATAAACGGTTCGAGTTTGCAAATTTACTTTTGGTATGCGATATAGATTTTTC
TTTAACCTTTGGAGTATTTC

Downstream 100 bases:

>100_bases
TTTTTATGATGAGCGGAGATTTCTTCTTTCGTAACAAAATTCCTGTTGCGATTTTAGGGGCCACAGGTTGTGTAGGGCAA
AAGTTCGTGCAACTTTTAAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLFLYVEGLVEMRVALLGLGEKN
KVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDAFIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISS
NKHVLALAEEVAAICDGVYYTRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDP
TLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAACHLDLKVNLTAIIPATENSVD
AASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQNLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLI
QAGENTHERLWRMPLYEGYQEKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYAS
GVGVRLLVEFLKQLSMVKN

Sequences:

>Translated_499_residues
MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLFLYVEGLVEMRVALLGLGEKN
KVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDAFIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISS
NKHVLALAEEVAAICDGVYYTRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDP
TLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAACHLDLKVNLTAIIPATENSVD
AASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQNLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLI
QAGENTHERLWRMPLYEGYQEKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYAS
GVGVRLLVEFLKQLSMVKN
>Mature_499_residues
MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLFLYVEGLVEMRVALLGLGEKN
KVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDAFIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISS
NKHVLALAEEVAAICDGVYYTRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDP
TLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAACHLDLKVNLTAIIPATENSVD
AASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQNLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLI
QAGENTHERLWRMPLYEGYQEKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYAS
GVGVRLLVEFLKQLSMVKN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=377, Percent_Identity=35.8090185676393, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI47155554, Length=411, Percent_Identity=28.4671532846715, Blast_Score=148, Evalue=9e-36,
Organism=Escherichia coli, GI1790710, Length=518, Percent_Identity=32.6254826254826, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=34.5794392523364, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=290, Percent_Identity=35.8620689655172, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=351, Percent_Identity=27.9202279202279, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355725, Length=276, Percent_Identity=36.231884057971, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI20129969, Length=327, Percent_Identity=31.4984709480122, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24661038, Length=276, Percent_Identity=35.1449275362319, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662227, Length=332, Percent_Identity=31.6265060240964, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI161077148, Length=324, Percent_Identity=31.4814814814815, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20130057, Length=324, Percent_Identity=31.4814814814815, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21355645, Length=325, Percent_Identity=28.9230769230769, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24662223, Length=325, Percent_Identity=28.9230769230769, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI19922386, Length=325, Percent_Identity=31.0769230769231, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI20129963, Length=385, Percent_Identity=29.3506493506493, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646701, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646703, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358201, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PARUW (Q6MC72)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008102.1
- ProteinModelPortal:   Q6MC72
- SMR:   Q6MC72
- STRING:   Q6MC72
- GeneID:   2780361
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1103
- NMPDR:   fig|264201.1.peg.1103
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- PhylomeDB:   Q6MC72
- ProtClustDB:   PRK00913
- BioCyc:   CPRO264201:PC1103-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54777; Mature: 54777

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 274-274 ACT_SITE 348-348

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLF
CCEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEEHEEEHHHHCCCCCCCCCCCCEEE
LYVEGLVEMRVALLGLGEKNKVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDA
EEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
FIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISSNKHVLALAEEVAAICDGVYY
HHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHH
TRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDP
HHHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCEEEEECCCCCCCC
TLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAAC
EEEEEEECCCCCCCCCEEEEECCEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHH
HLDLKVNLTAIIPATENSVDAASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQ
EEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEEEHHHHHHHHC
NLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLIQAGENTHERLWRMPLYEGYQ
CCCHHHEEEEEEECEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
EKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYAS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHHHCCHHHC
GVGVRLLVEFLKQLSMVKN
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLF
CCEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEEHEEEHHHHCCCCCCCCCCCCEEE
LYVEGLVEMRVALLGLGEKNKVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDA
EEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
FIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISSNKHVLALAEEVAAICDGVYY
HHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHH
TRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDP
HHHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCEEEEECCCCCCCC
TLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAAC
EEEEEEECCCCCCCCCEEEEECCEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHH
HLDLKVNLTAIIPATENSVDAASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQ
EEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCEEEHHHHHHHHC
NLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLIQAGENTHERLWRMPLYEGYQ
CCCHHHEEEEEEECEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
EKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYAS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHHHCCHHHC
GVGVRLLVEFLKQLSMVKN
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA