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The map label for this gene is glk [H]

Identifier: 46446569

GI number: 46446569

Start: 1126238

End: 1127221

Strand: Reverse

Name: glk [H]

Synonym: pc0935

Alternate gene names: 46446569

Gene position: 1127221-1126238 (Counterclockwise)

Preceding gene: 46446570

Following gene: 46446568

Centisome position: 46.69

GC content: 38.92

Gene sequence:

>984_bases
ATGCTAAAAGAAACAGATTGTGTCATTGGAATCGATTTAGGGGGAACCAAAATTGGGATAGGAGTTTTGAATGTCTCCGG
CACATTGATTGATAGTGTGAGACTTAAAACGGATTTTAAACACGGACCAGCTAGTGTCGAAAAACAAATCATGCAAGCGA
TTCAGGATTTAAAAAATCGGACAAAAGTTGAGATTAAAGGAATTGGAATAGGGGTAGCAGGTCAAATTGACGAAGAAACA
GGAGTCGTTCGTTTTGCTCCAAATCTCCCAGGCTGGCATCAAGTAACACTACGCAAAAATCTGGAAAGAGAAGCTGAAAT
TCCAGTTAAGGTTGTGAATGATGTTCGCGCTATTACTTGGGGAGAATGGCTTTACGGAGCTGGTAAACATTATCAAGATC
TTATTTGTTTATTCGTAGGAACAGGAATTGGCAGTGGTATCGTTTGCCAGGGAAAAATGCAAAAAGGGGATAATAATACA
TTTGGAGAAGTCGGCCATATGACAATCGATTTTCATGGCCCTCGTTGCACCTGCGGTAACAATGGTTGTTTTGAAGCTTT
TGCTGGAGGATGGGGAATTGCTAGACAGGCCAAAGAACTCATTCTTGCCGATAACCAAAGTGGTCAATCCATTTTAGAAA
AAGCAGGTGGATATTTAGAAAATGTTTCAGCTAAAGCTGTTATTGAAGCATACCACAGTGGAGACCCTCTAGCTCTATTA
ATTTTAGAAAAAGTCAAGCAAGCCTTAATTGCAGGTTGCATTAATCTTGTGAATGCTTTTAATCCTGCTTGTTTAATCTT
AGGAGGTGGGGTTCTAGATGGTATTCCAGAAATCCTATCATTTATTGATAAAGGCATTCGAGAAACTGCTTTAAAAACGG
CGACAGACAAATTACAGATAAAAACTGCTTTACTTGGTAAAAATGTGGGAATTATTGGATCTGGAGCTGTAATTTTAGAC
GTCTTAAAAAATAACGTTGGGTGA

Upstream 100 bases:

>100_bases
TTAAGGGATTACCAAGCAAAATTGTTCCCCTTATGTTATTTGCTAATTTTCTTACCAACATAAGTTACAAATTTAAAAAC
TGTAAAACTGTATGGAAAAT

Downstream 100 bases:

>100_bases
GAGGAGTATGAGTAAACAATTATTTACTTCATTATTTATCGATGTTGGCGGCGTCCTTTTGACAAATGGATGGGATCGAC
ATATGCGTGAAAAGGCTTCA

Product: putative glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MLKETDCVIGIDLGGTKIGIGVLNVSGTLIDSVRLKTDFKHGPASVEKQIMQAIQDLKNRTKVEIKGIGIGVAGQIDEET
GVVRFAPNLPGWHQVTLRKNLEREAEIPVKVVNDVRAITWGEWLYGAGKHYQDLICLFVGTGIGSGIVCQGKMQKGDNNT
FGEVGHMTIDFHGPRCTCGNNGCFEAFAGGWGIARQAKELILADNQSGQSILEKAGGYLENVSAKAVIEAYHSGDPLALL
ILEKVKQALIAGCINLVNAFNPACLILGGGVLDGIPEILSFIDKGIRETALKTATDKLQIKTALLGKNVGIIGSGAVILD
VLKNNVG

Sequences:

>Translated_327_residues
MLKETDCVIGIDLGGTKIGIGVLNVSGTLIDSVRLKTDFKHGPASVEKQIMQAIQDLKNRTKVEIKGIGIGVAGQIDEET
GVVRFAPNLPGWHQVTLRKNLEREAEIPVKVVNDVRAITWGEWLYGAGKHYQDLICLFVGTGIGSGIVCQGKMQKGDNNT
FGEVGHMTIDFHGPRCTCGNNGCFEAFAGGWGIARQAKELILADNQSGQSILEKAGGYLENVSAKAVIEAYHSGDPLALL
ILEKVKQALIAGCINLVNAFNPACLILGGGVLDGIPEILSFIDKGIRETALKTATDKLQIKTALLGKNVGIIGSGAVILD
VLKNNVG
>Mature_327_residues
MLKETDCVIGIDLGGTKIGIGVLNVSGTLIDSVRLKTDFKHGPASVEKQIMQAIQDLKNRTKVEIKGIGIGVAGQIDEET
GVVRFAPNLPGWHQVTLRKNLEREAEIPVKVVNDVRAITWGEWLYGAGKHYQDLICLFVGTGIGSGIVCQGKMQKGDNNT
FGEVGHMTIDFHGPRCTCGNNGCFEAFAGGWGIARQAKELILADNQSGQSILEKAGGYLENVSAKAVIEAYHSGDPLALL
ILEKVKQALIAGCINLVNAFNPACLILGGGVLDGIPEILSFIDKGIRETALKTATDKLQIKTALLGKNVGIIGSGAVILD
VLKNNVG

Specific function: May Be A Regulator In Specific Sugar Metabolism. May Influence The Rate Of Glucose Uptake Or Glycolysis In Cells In The Rich Medium. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=297, Percent_Identity=30.6397306397306, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI298566325, Length=297, Percent_Identity=30.6397306397306, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4885285, Length=297, Percent_Identity=30.6397306397306, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI190014632, Length=297, Percent_Identity=30.6397306397306, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI298566312, Length=144, Percent_Identity=31.9444444444444, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787878, Length=269, Percent_Identity=27.1375464684015, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786891, Length=329, Percent_Identity=25.531914893617, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081733, Length=275, Percent_Identity=28, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787363, Length=285, Percent_Identity=27.719298245614, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082230, Length=264, Percent_Identity=26.8939393939394, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790522, Length=276, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082127, Length=195, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 34709; Mature: 34709

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKETDCVIGIDLGGTKIGIGVLNVSGTLIDSVRLKTDFKHGPASVEKQIMQAIQDLKNR
CCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
TKVEIKGIGIGVAGQIDEETGVVRFAPNLPGWHQVTLRKNLEREAEIPVKVVNDVRAITW
CEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEHHHHCCCCCCCCCHHHHHCHHHEEE
GEWLYGAGKHYQDLICLFVGTGIGSGIVCQGKMQKGDNNTFGEVGHMTIDFHGPRCTCGN
HHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEECCC
NGCFEAFAGGWGIARQAKELILADNQSGQSILEKAGGYLENVSAKAVIEAYHSGDPLALL
CCCHHHHCCCCHHHHHHHHHEEECCCCCHHHHHHCCCHHHCCCHHHHHHHHCCCCCEEHH
ILEKVKQALIAGCINLVNAFNPACLILGGGVLDGIPEILSFIDKGIRETALKTATDKLQI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
KTALLGKNVGIIGSGAVILDVLKNNVG
EEHHHCCCCCEEECCHHHHHHHHCCCC
>Mature Secondary Structure
MLKETDCVIGIDLGGTKIGIGVLNVSGTLIDSVRLKTDFKHGPASVEKQIMQAIQDLKNR
CCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
TKVEIKGIGIGVAGQIDEETGVVRFAPNLPGWHQVTLRKNLEREAEIPVKVVNDVRAITW
CEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEHHHHCCCCCCCCCHHHHHCHHHEEE
GEWLYGAGKHYQDLICLFVGTGIGSGIVCQGKMQKGDNNTFGEVGHMTIDFHGPRCTCGN
HHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEECCC
NGCFEAFAGGWGIARQAKELILADNQSGQSILEKAGGYLENVSAKAVIEAYHSGDPLALL
CCCHHHHCCCCHHHHHHHHHEEECCCCCHHHHHHCCCHHHCCCHHHHHHHHCCCCCEEHH
ILEKVKQALIAGCINLVNAFNPACLILGGGVLDGIPEILSFIDKGIRETALKTATDKLQI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
KTALLGKNVGIIGSGAVILDVLKNNVG
EEHHHCCCCCEEECCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]