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The map label for this gene is mutM

Identifier: 46446526

GI number: 46446526

Start: 1076920

End: 1077750

Strand: Reverse

Name: mutM

Synonym: pc0892

Alternate gene names: 46446526

Gene position: 1077750-1076920 (Counterclockwise)

Preceding gene: 46446528

Following gene: 46446525

Centisome position: 44.64

GC content: 36.94

Gene sequence:

>831_bases
ATGCCTGAACTCCCCGAAGTCCATACCATTGTCCAAGATTTGAAACAAAGTAGGCTTATTGGTAAAAAAATTATTTCTAC
AGAAATTTTTTGGCCTAAAACGCTTGCAGTACCTACACCTGAAATTTTCTGTCAGCAAGTCCAAGGTCAATCTATCCAAA
ATGTTGACAGAAGGGGTAAATACATCATTTTTCAACTTTCCAATCAGATGTTCCTCATTGTTCATTTAAGAATGACAGGC
CGGTTTCAATTTGTTACAAGCCAAACCCCAGCCTCTCCTTACGTTCGAATACAATTTAATTTTGAAAATGGCGATCAGCT
TCGTTTTCATGATACACGCAAATTTGGTCGTTGGTATTTAGTTTCTGATGTAGAGGAAATTATAGGACACTTAGGTCCCG
AACCTTTACTTTCCTCTTTTACATTCGAACTATTTGAAGATATGATGAAAAATCGAAAAACTTTATTAAAAAGCTTACTA
CTAGACCAAAGTTTCATTGTAGGTCTTGGTAATATTTATGTGGATGAAGCTCTGTGGGAAGCAAAACTACATCCTTTGAT
TCCCGCCAATCAAATAAATCTAAAACACCTAAAGATTCTTTATCATAGCATTAAATATGTCCTTGAAAAAGGGATCCAAG
CAAGAGGAACAACGCTTGGACCTGGGCGAACACACTATTATCGCTTAGATGGTTCAAAAGGAGAACACCAAACTCTTTTA
AATGTCTTTCGAAAAACTGGACATCCTTGTCCTCGATGTGGTCATTTAATTGAAAAGCTAATTGTCGCGCAGCGAAGTAC
ACACATTTGCCCCATCTGCCAAAAAAAATGA

Upstream 100 bases:

>100_bases
TCCCTAAATCCCTAAAATTGGGCAAAATTTCCTTTGTAATTAAATTCTATTTTGCAGCTAATCAATAATTAAAAATGATT
GTAACTAAAATGAATTAACT

Downstream 100 bases:

>100_bases
TACAAGCTTAAAAGGAATTTATGTTTACTGGGTTAGTAGAGGAAGTGGGATGTCTCACAAAGATTGAAAAACGGGGTGAT
GGAATTCGTTTTCAGATTGA

Product: putative formamidopyrimidine-DNA glycosidase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MPELPEVHTIVQDLKQSRLIGKKIISTEIFWPKTLAVPTPEIFCQQVQGQSIQNVDRRGKYIIFQLSNQMFLIVHLRMTG
RFQFVTSQTPASPYVRIQFNFENGDQLRFHDTRKFGRWYLVSDVEEIIGHLGPEPLLSSFTFELFEDMMKNRKTLLKSLL
LDQSFIVGLGNIYVDEALWEAKLHPLIPANQINLKHLKILYHSIKYVLEKGIQARGTTLGPGRTHYYRLDGSKGEHQTLL
NVFRKTGHPCPRCGHLIEKLIVAQRSTHICPICQKK

Sequences:

>Translated_276_residues
MPELPEVHTIVQDLKQSRLIGKKIISTEIFWPKTLAVPTPEIFCQQVQGQSIQNVDRRGKYIIFQLSNQMFLIVHLRMTG
RFQFVTSQTPASPYVRIQFNFENGDQLRFHDTRKFGRWYLVSDVEEIIGHLGPEPLLSSFTFELFEDMMKNRKTLLKSLL
LDQSFIVGLGNIYVDEALWEAKLHPLIPANQINLKHLKILYHSIKYVLEKGIQARGTTLGPGRTHYYRLDGSKGEHQTLL
NVFRKTGHPCPRCGHLIEKLIVAQRSTHICPICQKK
>Mature_275_residues
PELPEVHTIVQDLKQSRLIGKKIISTEIFWPKTLAVPTPEIFCQQVQGQSIQNVDRRGKYIIFQLSNQMFLIVHLRMTGR
FQFVTSQTPASPYVRIQFNFENGDQLRFHDTRKFGRWYLVSDVEEIIGHLGPEPLLSSFTFELFEDMMKNRKTLLKSLLL
DQSFIVGLGNIYVDEALWEAKLHPLIPANQINLKHLKILYHSIKYVLEKGIQARGTTLGPGRTHYYRLDGSKGEHQTLLN
VFRKTGHPCPRCGHLIEKLIVAQRSTHICPICQKK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=282, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786932, Length=290, Percent_Identity=27.2413793103448, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PARUW (Q6MCT3)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007891.1
- ProteinModelPortal:   Q6MCT3
- SMR:   Q6MCT3
- STRING:   Q6MCT3
- GeneID:   2779599
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0892
- NMPDR:   fig|264201.1.peg.892
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q6MCT3
- BioCyc:   CPRO264201:PC0892-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31918; Mature: 31787

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2; PS00284 SERPIN

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 265-265 BINDING 113-113 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVHTIVQDLKQSRLIGKKIISTEIFWPKTLAVPTPEIFCQQVQGQSIQNVDRRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCHHHHHHHCCC
YIIFQLSNQMFLIVHLRMTGRFQFVTSQTPASPYVRIQFNFENGDQLRFHDTRKFGRWYL
EEEEEECCCEEEEEEEEECCEEEEEECCCCCCCEEEEEEEECCCCEEEEECHHHHCCEEE
VSDVEEIIGHLGPEPLLSSFTFELFEDMMKNRKTLLKSLLLDQSFIVGLGNIYVDEALWE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
AKLHPLIPANQINLKHLKILYHSIKYVLEKGIQARGTTLGPGRTHYYRLDGSKGEHQTLL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
NVFRKTGHPCPRCGHLIEKLIVAQRSTHICPICQKK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVHTIVQDLKQSRLIGKKIISTEIFWPKTLAVPTPEIFCQQVQGQSIQNVDRRGK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCHHHHHHHCCC
YIIFQLSNQMFLIVHLRMTGRFQFVTSQTPASPYVRIQFNFENGDQLRFHDTRKFGRWYL
EEEEEECCCEEEEEEEEECCEEEEEECCCCCCCEEEEEEEECCCCEEEEECHHHHCCEEE
VSDVEEIIGHLGPEPLLSSFTFELFEDMMKNRKTLLKSLLLDQSFIVGLGNIYVDEALWE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
AKLHPLIPANQINLKHLKILYHSIKYVLEKGIQARGTTLGPGRTHYYRLDGSKGEHQTLL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
NVFRKTGHPCPRCGHLIEKLIVAQRSTHICPICQKK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA