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The map label for this gene is sdaB [H]

Identifier: 46446512

GI number: 46446512

Start: 1060300

End: 1061691

Strand: Direct

Name: sdaB [H]

Synonym: pc0878

Alternate gene names: 46446512

Gene position: 1060300-1061691 (Clockwise)

Preceding gene: 46446511

Following gene: 46446513

Centisome position: 43.91

GC content: 39.44

Gene sequence:

>1392_bases
ATGGCTGTCAGTGTGTTTAATTTATTTTCGATTGGTATTGGCCCTTCGAGTTCGCACACAGTTGGACCCATGCGCGCAGC
GCGACAGTTTGTGGTCAATTTACAGTTAAACGATATGTTAGTGGATGTCCACAGAATAAAAATGGAGCTTTATGGCTCAT
TGGCTTTAACAGGAAAAGGACACTCCACAGATATTGCTGTTTTGCTTGGCGTAGAAGGAAATGCTCCGGAAGGAATCGAC
CCAAGAGATGTAGAGCCACGCATTAAATGGATTCGGGAAAATTGCAAAATCTCTTTACTTAATTCTCGATTGATTGAGTT
TCAAGAAGAAGTTGATTTAATTTTCCATTCTGATAAACAGCTTCCTTTTCATCCCAATGGAATGCGATTTACAGCCTTTA
ATACCTGCCATCGAGAAATATCTCAAGAAGTTTTTTATTCAGTAGGCGGTGGCTTTATTGTCGATCATCATGCAGCCATG
AAAGATGAAACAATTTGTCAAAATGATCATCATTTACCTTATCCTTTTAAAACGGCGGATGAATTATTACTTCTTTGTAA
AAAACATAATTTTTCAATTGCTGAATTGATGTGGGAAAACGAAAAATCTTGGCGTACAGAAGAAGAAATTGAAATAGGAC
TTCTCAATATTTGGAATGTCATGCAGACTTGTGTAAAGCATGGCTGCGAAAAAGAAGGGGTATTACCTGGGGGCCTAAAT
GTTAAAAGACGCGCAGCAAGTATCTATCGATATTTACAAGAACAAGAATTAAAACCTTTAGAAAAGCGAGATCGTGCTGA
AGTTATAGATTGGGTCAGTCTGTGGGCATTGGCTGTCAATGAAGAAAATGCAGCAGGAGGGCGTGTTGTCACAGCTCCAA
CGAACGGAGCAGCCGGAGTCATTCCCGCTGTGCTTCATTACTATGAAAAATTTATAAAAAATTCAAATTCTAAAGGAATT
ATCACTTTTTTATTAGTTGCTGGAGCAATTGGAATTTTATACAAAGAAGGAGCTTCGATTTCAGCGGCAGAAATGGGGTG
TATGGGAGAAGTTGGGGTTGCGTGTTCAATGGCAGCAGCTGGCCTTGCAGCCGCTCTTGGTGCAAGCAATGAACAAATTG
AAAATGCAGCAGAAATCGGAATGGAACATAATTTGGGATTAACCTGTGATCCCATTAAAGGTTTAGTGCAAATTCCTTGT
ATTGAAAGAAATACAATGGGGGCTACTAAAGCGATTAATGCAGAAAGATTAGCTAGACTACATGGAGATGGTACGCACCG
AGTAACTTTAGATCAAGTAATCGCCACAATGAAACAAACTGGCCATGATATGATGTCTATTTATAAAGAAACATCTCAAG
GTGGGCTGGCTGTTAATGTACCAGAATGTTAG

Upstream 100 bases:

>100_bases
TTATCTTCAAATAATTTTTCTTTGTGTAATGAAACTTTTTTGCTAAAATATTCGATCTCTTGTCAAGAATAGGCAAAAAA
TCATTAATTAAGGATTTTTT

Downstream 100 bases:

>100_bases
GCTAAAGAAATAACTGCAAAAATAAAGCTGTTTAAAAATCTAGTTGTTTTAGTCTTGTCATTGCCTTTTAATTTTTTCAA
TATTTTTAGGATTCCATGCA

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAVSVFNLFSIGIGPSSSHTVGPMRAARQFVVNLQLNDMLVDVHRIKMELYGSLALTGKGHSTDIAVLLGVEGNAPEGID
PRDVEPRIKWIRENCKISLLNSRLIEFQEEVDLIFHSDKQLPFHPNGMRFTAFNTCHREISQEVFYSVGGGFIVDHHAAM
KDETICQNDHHLPYPFKTADELLLLCKKHNFSIAELMWENEKSWRTEEEIEIGLLNIWNVMQTCVKHGCEKEGVLPGGLN
VKRRAASIYRYLQEQELKPLEKRDRAEVIDWVSLWALAVNEENAAGGRVVTAPTNGAAGVIPAVLHYYEKFIKNSNSKGI
ITFLLVAGAIGILYKEGASISAAEMGCMGEVGVACSMAAAGLAAALGASNEQIENAAEIGMEHNLGLTCDPIKGLVQIPC
IERNTMGATKAINAERLARLHGDGTHRVTLDQVIATMKQTGHDMMSIYKETSQGGLAVNVPEC

Sequences:

>Translated_463_residues
MAVSVFNLFSIGIGPSSSHTVGPMRAARQFVVNLQLNDMLVDVHRIKMELYGSLALTGKGHSTDIAVLLGVEGNAPEGID
PRDVEPRIKWIRENCKISLLNSRLIEFQEEVDLIFHSDKQLPFHPNGMRFTAFNTCHREISQEVFYSVGGGFIVDHHAAM
KDETICQNDHHLPYPFKTADELLLLCKKHNFSIAELMWENEKSWRTEEEIEIGLLNIWNVMQTCVKHGCEKEGVLPGGLN
VKRRAASIYRYLQEQELKPLEKRDRAEVIDWVSLWALAVNEENAAGGRVVTAPTNGAAGVIPAVLHYYEKFIKNSNSKGI
ITFLLVAGAIGILYKEGASISAAEMGCMGEVGVACSMAAAGLAAALGASNEQIENAAEIGMEHNLGLTCDPIKGLVQIPC
IERNTMGATKAINAERLARLHGDGTHRVTLDQVIATMKQTGHDMMSIYKETSQGGLAVNVPEC
>Mature_462_residues
AVSVFNLFSIGIGPSSSHTVGPMRAARQFVVNLQLNDMLVDVHRIKMELYGSLALTGKGHSTDIAVLLGVEGNAPEGIDP
RDVEPRIKWIRENCKISLLNSRLIEFQEEVDLIFHSDKQLPFHPNGMRFTAFNTCHREISQEVFYSVGGGFIVDHHAAMK
DETICQNDHHLPYPFKTADELLLLCKKHNFSIAELMWENEKSWRTEEEIEIGLLNIWNVMQTCVKHGCEKEGVLPGGLNV
KRRAASIYRYLQEQELKPLEKRDRAEVIDWVSLWALAVNEENAAGGRVVTAPTNGAAGVIPAVLHYYEKFIKNSNSKGII
TFLLVAGAIGILYKEGASISAAEMGCMGEVGVACSMAAAGLAAALGASNEQIENAAEIGMEHNLGLTCDPIKGLVQIPCI
ERNTMGATKAINAERLARLHGDGTHRVTLDQVIATMKQTGHDMMSIYKETSQGGLAVNVPEC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=463, Percent_Identity=50.9719222462203, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1788116, Length=459, Percent_Identity=50.1089324618736, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI48994925, Length=460, Percent_Identity=49.5652173913044, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 50816; Mature: 50685

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFNLFSIGIGPSSSHTVGPMRAARQFVVNLQLNDMLVDVHRIKMELYGSLALTGKG
CEEEEEEHEEECCCCCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCEEEECCC
HSTDIAVLLGVEGNAPEGIDPRDVEPRIKWIRENCKISLLNSRLIEFQEEVDLIFHSDKQ
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHEEEECCCC
LPFHPNGMRFTAFNTCHREISQEVFYSVGGGFIVDHHAAMKDETICQNDHHLPYPFKTAD
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCHHCCCCCCCCCCCCCHH
ELLLLCKKHNFSIAELMWENEKSWRTEEEIEIGLLNIWNVMQTCVKHGCEKEGVLPGGLN
HHHHHHHCCCCCHHHHHCCCCCCCCCCCHHEEHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VKRRAASIYRYLQEQELKPLEKRDRAEVIDWVSLWALAVNEENAAGGRVVTAPTNGAAGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHH
IPAVLHYYEKFIKNSNSKGIITFLLVAGAIGILYKEGASISAAEMGCMGEVGVACSMAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCHHHHHHHHHH
GLAAALGASNEQIENAAEIGMEHNLGLTCDPIKGLVQIPCIERNTMGATKAINAERLARL
HHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCEECCCCCCCCCCCHHHCCHHHHHHH
HGDGTHRVTLDQVIATMKQTGHDMMSIYKETSQGGLAVNVPEC
CCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCC
>Mature Secondary Structure 
AVSVFNLFSIGIGPSSSHTVGPMRAARQFVVNLQLNDMLVDVHRIKMELYGSLALTGKG
EEEEEEHEEECCCCCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCEEEECCC
HSTDIAVLLGVEGNAPEGIDPRDVEPRIKWIRENCKISLLNSRLIEFQEEVDLIFHSDKQ
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHEEEECCCC
LPFHPNGMRFTAFNTCHREISQEVFYSVGGGFIVDHHAAMKDETICQNDHHLPYPFKTAD
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCHHCCCCCCCCCCCCCHH
ELLLLCKKHNFSIAELMWENEKSWRTEEEIEIGLLNIWNVMQTCVKHGCEKEGVLPGGLN
HHHHHHHCCCCCHHHHHCCCCCCCCCCCHHEEHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VKRRAASIYRYLQEQELKPLEKRDRAEVIDWVSLWALAVNEENAAGGRVVTAPTNGAAGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHH
IPAVLHYYEKFIKNSNSKGIITFLLVAGAIGILYKEGASISAAEMGCMGEVGVACSMAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCHHHHHHHHHH
GLAAALGASNEQIENAAEIGMEHNLGLTCDPIKGLVQIPCIERNTMGATKAINAERLARL
HHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCEECCCCCCCCCCCHHHCCHHHHHHH
HGDGTHRVTLDQVIATMKQTGHDMMSIYKETSQGGLAVNVPEC
CCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]