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The map label for this gene is lolE [H]

Identifier: 46446450

GI number: 46446450

Start: 997519

End: 999651

Strand: Reverse

Name: lolE [H]

Synonym: pc0816

Alternate gene names: 46446450

Gene position: 999651-997519 (Counterclockwise)

Preceding gene: 46446451

Following gene: 46446449

Centisome position: 41.4

GC content: 34.97

Gene sequence:

>2133_bases
ATGTTTGAGCTTTCTGTCGCCTGCAAATATCTTATTCCCCGCCGGCGACAGCTCTCTGTTTCCATTATAAGTATCATCTC
TGTTTTAGTCATTAGCCTAGTTGTCTGGTTAATCATTGTTTTTTTCTCCGTTACCAATGGCCTAGAAAAAAATTGGATTT
ATAAACTCACTACTTTAACCGCACCTGTTCGAATTACCCCTACCGATGCTTATTACCACTCTTACTATTATCAAATTGAT
AGTTTAAGCGAAAATTCCGGTTATAGTCACAAAACAATACGGGAAAAGAACGAATCACAGTTCACAGATCCTTACGATAA
AGATTATGATGAAGAAATTCCTTCTCACTGGCAAACTCCAGATCGTCAACCTGATGGATCTCTAAAAGACCTTGTTAAAT
TAGCTTTCAATTCGATTCAGAATCTGAAGAAAATACCTGGCTTATATGCTCAAGACTTTGAATTAACAGCTAGCCATATT
AAACTTCGCCTTCAAAGAGACATGTCCGTTTTGCATGCACACAATTTTTATGGAGGTGCAACGCAATCATATTTAGCTTA
TCCAACCTACTTAGGTAACTTTGAAGCAAATAACTCCAAAATTGGCCAAACTTTTTTACCTATCGAATCAAAAGATCTCA
ATAATTATTTACAATTGATTCCTTTTGCAGAGAATCATGAAGATAATCCAGATGAAAAAATTCCTTTTCCTCAAACGATA
CTGCAAAAAAGATTAAGAATTTTTTTTGATCATGTCATGATCAATCAACTACAAGCTAAATCATTTGGTTGGACAATTCC
GAAAACTTTATTTCCTTTAAAAGCCCATTGGCAAGGATGTGCTGTTACTAAAGAGAACCATATTTTACGAATTGTTGTTC
CTGCCCAATCCGAAAAATGCATGCAAATTCAAAAGTCTCTTGAAGACCAAGGTTTAGAAACGATTTTGGGACAATTGCAT
CTTGATGAAGGAAAAGCAATATTTTATGGAAAAAATCAAACTGTTTTTAATGATCTAACGAAAATTCCTATCACTTACGC
TAGTGGGAATTCTTTTGAAGCTCATTTAATCTCCTCTTCAATCGAACGAGCCAAAAGATTAGATGATCTTACTTTTGAGA
TAACCGTGCCTATCCAAGGTGATATTTTAAAAGGAAATGTCCCTTATCGAGGACTAGAAATTGCCTCTGCGGAATTAAAA
CCCACCAATAAAAATTTTGGCAACCCCTTCTGGGTTTATCAATCATCCGCAAATTCAAATTTTATTCTTCCCTCGGATTC
GGATATAGGCGGAGGGATAATTTTACCTAAAAGTTTCAGAGAAGCTGGGGTTTTGATTGGCGATCGGGGACACTTAAGCT
ATTTTGCTGCGACTGCAAGCCTTTTGCAAGAACAGCGTCTTCCAATTTATGTTGCAGGATTTTATGATCCAGGAATTATT
CCAATTGGTAATAAATTTGTTTTAGCCAATCCAGAAATCACCTCTATTATTCGAGCATCTCATAATCAAGATGATAAATC
TAGTTTAACGAATGGAATTAATATTCGTTTCGATCATTTAAGCCAAGCAGATGAAGTGAAAGACGCCTTATTAAAGGCTT
TTCAAAAAAATGGGATCAGTCGTTACTGGGATATACAAACTTATAAAGAATACGAATTTACAAAAGAAATTATTCAAGAG
CTTCAGAGTCAAAAAAATATTTTTATGTTGATTGCCGTGGTTATTATTCTCGTGGCCTGTTCTAATATTATTTCTATGCT
CGTTATTTTGGTAAATGATAAAAAAGTTGAGATCGGAATTCTTCGTTCAATGGGAGCTTCTTCAAAAAGTATTGCCCTTA
TATTTGGATTTGCAGGTGGAGTAATTGGTATCCTAGGAAGTTTAATTGGAATTGGAGCAGCTATACTGACTTTAAGTTAT
TTAAGCACTCTTATTGCCTTTTTAAGTCGTTTGCAAGGACATGATATGCTTAACGCTTCTTTTTATGGACAAATGTTAAC
ACATGAAATTAGTTATGAAGCGTTATTTTTTGTTTTAGGAGCGACTTGTATGATTTCTTTACTAGCAGGTATTGTACCTG
CTGTCAAGGCTTGTCTTTTAAAACCCTCTCAAATTCTAAGATCTGGGAGTTAA

Upstream 100 bases:

>100_bases
ACTCCAGGACGTCTAACATTAGTTAAATATGATCCAGTCGTACGTGAGAGAGTAGAATTTAAAGAAACAAAGTAATTTTT
TTACTTTTGGTGCATAAAAC

Downstream 100 bases:

>100_bases
ATGCATTCTCATTCAACCTTAATTCTTGAAGCTCATGATATTCAAAAAAACTTCTATCATCCTGTGCAAGTAAAAATTCT
ACAAAGCGTTTCTCTTCAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 710; Mature: 710

Protein sequence:

>710_residues
MFELSVACKYLIPRRRQLSVSIISIISVLVISLVVWLIIVFFSVTNGLEKNWIYKLTTLTAPVRITPTDAYYHSYYYQID
SLSENSGYSHKTIREKNESQFTDPYDKDYDEEIPSHWQTPDRQPDGSLKDLVKLAFNSIQNLKKIPGLYAQDFELTASHI
KLRLQRDMSVLHAHNFYGGATQSYLAYPTYLGNFEANNSKIGQTFLPIESKDLNNYLQLIPFAENHEDNPDEKIPFPQTI
LQKRLRIFFDHVMINQLQAKSFGWTIPKTLFPLKAHWQGCAVTKENHILRIVVPAQSEKCMQIQKSLEDQGLETILGQLH
LDEGKAIFYGKNQTVFNDLTKIPITYASGNSFEAHLISSSIERAKRLDDLTFEITVPIQGDILKGNVPYRGLEIASAELK
PTNKNFGNPFWVYQSSANSNFILPSDSDIGGGIILPKSFREAGVLIGDRGHLSYFAATASLLQEQRLPIYVAGFYDPGII
PIGNKFVLANPEITSIIRASHNQDDKSSLTNGINIRFDHLSQADEVKDALLKAFQKNGISRYWDIQTYKEYEFTKEIIQE
LQSQKNIFMLIAVVIILVACSNIISMLVILVNDKKVEIGILRSMGASSKSIALIFGFAGGVIGILGSLIGIGAAILTLSY
LSTLIAFLSRLQGHDMLNASFYGQMLTHEISYEALFFVLGATCMISLLAGIVPAVKACLLKPSQILRSGS

Sequences:

>Translated_710_residues
MFELSVACKYLIPRRRQLSVSIISIISVLVISLVVWLIIVFFSVTNGLEKNWIYKLTTLTAPVRITPTDAYYHSYYYQID
SLSENSGYSHKTIREKNESQFTDPYDKDYDEEIPSHWQTPDRQPDGSLKDLVKLAFNSIQNLKKIPGLYAQDFELTASHI
KLRLQRDMSVLHAHNFYGGATQSYLAYPTYLGNFEANNSKIGQTFLPIESKDLNNYLQLIPFAENHEDNPDEKIPFPQTI
LQKRLRIFFDHVMINQLQAKSFGWTIPKTLFPLKAHWQGCAVTKENHILRIVVPAQSEKCMQIQKSLEDQGLETILGQLH
LDEGKAIFYGKNQTVFNDLTKIPITYASGNSFEAHLISSSIERAKRLDDLTFEITVPIQGDILKGNVPYRGLEIASAELK
PTNKNFGNPFWVYQSSANSNFILPSDSDIGGGIILPKSFREAGVLIGDRGHLSYFAATASLLQEQRLPIYVAGFYDPGII
PIGNKFVLANPEITSIIRASHNQDDKSSLTNGINIRFDHLSQADEVKDALLKAFQKNGISRYWDIQTYKEYEFTKEIIQE
LQSQKNIFMLIAVVIILVACSNIISMLVILVNDKKVEIGILRSMGASSKSIALIFGFAGGVIGILGSLIGIGAAILTLSY
LSTLIAFLSRLQGHDMLNASFYGQMLTHEISYEALFFVLGATCMISLLAGIVPAVKACLLKPSQILRSGS
>Mature_710_residues
MFELSVACKYLIPRRRQLSVSIISIISVLVISLVVWLIIVFFSVTNGLEKNWIYKLTTLTAPVRITPTDAYYHSYYYQID
SLSENSGYSHKTIREKNESQFTDPYDKDYDEEIPSHWQTPDRQPDGSLKDLVKLAFNSIQNLKKIPGLYAQDFELTASHI
KLRLQRDMSVLHAHNFYGGATQSYLAYPTYLGNFEANNSKIGQTFLPIESKDLNNYLQLIPFAENHEDNPDEKIPFPQTI
LQKRLRIFFDHVMINQLQAKSFGWTIPKTLFPLKAHWQGCAVTKENHILRIVVPAQSEKCMQIQKSLEDQGLETILGQLH
LDEGKAIFYGKNQTVFNDLTKIPITYASGNSFEAHLISSSIERAKRLDDLTFEITVPIQGDILKGNVPYRGLEIASAELK
PTNKNFGNPFWVYQSSANSNFILPSDSDIGGGIILPKSFREAGVLIGDRGHLSYFAATASLLQEQRLPIYVAGFYDPGII
PIGNKFVLANPEITSIIRASHNQDDKSSLTNGINIRFDHLSQADEVKDALLKAFQKNGISRYWDIQTYKEYEFTKEIIQE
LQSQKNIFMLIAVVIILVACSNIISMLVILVNDKKVEIGILRSMGASSKSIALIFGFAGGVIGILGSLIGIGAAILTLSY
LSTLIAFLSRLQGHDMLNASFYGQMLTHEISYEALFFVLGATCMISLLAGIVPAVKACLLKPSQILRSGS

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=149, Percent_Identity=34.2281879194631, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 79538; Mature: 79538

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELSVACKYLIPRRRQLSVSIISIISVLVISLVVWLIIVFFSVTNGLEKNWIYKLTTLT
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEE
APVRITPTDAYYHSYYYQIDSLSENSGYSHKTIREKNESQFTDPYDKDYDEEIPSHWQTP
CCEEECCCHHHHHEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
DRQPDGSLKDLVKLAFNSIQNLKKIPGLYAQDFELTASHIKLRLQRDMSVLHAHNFYGGA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TQSYLAYPTYLGNFEANNSKIGQTFLPIESKDLNNYLQLIPFAENHEDNPDEKIPFPQTI
CCCCEECCCEECCCCCCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LQKRLRIFFDHVMINQLQAKSFGWTIPKTLFPLKAHWQGCAVTKENHILRIVVPAQSEKC
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHCCCCCEEECCCCEEEEEECCCCHHH
MQIQKSLEDQGLETILGQLHLDEGKAIFYGKNQTVFNDLTKIPITYASGNSFEAHLISSS
HHHHHHHHHCCHHHHHHHHEECCCCEEEEECCCHHHHHHHCCEEEEECCCCCCHHHHHHH
IERAKRLDDLTFEITVPIQGDILKGNVPYRGLEIASAELKPTNKNFGNPFWVYQSSANSN
HHHHHHHCCCEEEEEEEECCCEEECCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCC
FILPSDSDIGGGIILPKSFREAGVLIGDRGHLSYFAATASLLQEQRLPIYVAGFYDPGII
EECCCCCCCCCCEECCCCHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEE
PIGNKFVLANPEITSIIRASHNQDDKSSLTNGINIRFDHLSQADEVKDALLKAFQKNGIS
ECCCEEEEECCHHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
RYWDIQTYKEYEFTKEIIQELQSQKNIFMLIAVVIILVACSNIISMLVILVNDKKVEIGI
EEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEE
LRSMGASSKSIALIFGFAGGVIGILGSLIGIGAAILTLSYLSTLIAFLSRLQGHDMLNAS
HHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FYGQMLTHEISYEALFFVLGATCMISLLAGIVPAVKACLLKPSQILRSGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MFELSVACKYLIPRRRQLSVSIISIISVLVISLVVWLIIVFFSVTNGLEKNWIYKLTTLT
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEE
APVRITPTDAYYHSYYYQIDSLSENSGYSHKTIREKNESQFTDPYDKDYDEEIPSHWQTP
CCEEECCCHHHHHEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
DRQPDGSLKDLVKLAFNSIQNLKKIPGLYAQDFELTASHIKLRLQRDMSVLHAHNFYGGA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TQSYLAYPTYLGNFEANNSKIGQTFLPIESKDLNNYLQLIPFAENHEDNPDEKIPFPQTI
CCCCEECCCEECCCCCCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LQKRLRIFFDHVMINQLQAKSFGWTIPKTLFPLKAHWQGCAVTKENHILRIVVPAQSEKC
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHCCCCCEEECCCCEEEEEECCCCHHH
MQIQKSLEDQGLETILGQLHLDEGKAIFYGKNQTVFNDLTKIPITYASGNSFEAHLISSS
HHHHHHHHHCCHHHHHHHHEECCCCEEEEECCCHHHHHHHCCEEEEECCCCCCHHHHHHH
IERAKRLDDLTFEITVPIQGDILKGNVPYRGLEIASAELKPTNKNFGNPFWVYQSSANSN
HHHHHHHCCCEEEEEEEECCCEEECCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCC
FILPSDSDIGGGIILPKSFREAGVLIGDRGHLSYFAATASLLQEQRLPIYVAGFYDPGII
EECCCCCCCCCCEECCCCHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEE
PIGNKFVLANPEITSIIRASHNQDDKSSLTNGINIRFDHLSQADEVKDALLKAFQKNGIS
ECCCEEEEECCHHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
RYWDIQTYKEYEFTKEIIQELQSQKNIFMLIAVVIILVACSNIISMLVILVNDKKVEIGI
EEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEE
LRSMGASSKSIALIFGFAGGVIGILGSLIGIGAAILTLSYLSTLIAFLSRLQGHDMLNAS
HHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FYGQMLTHEISYEALFFVLGATCMISLLAGIVPAVKACLLKPSQILRSGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]