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The map label for this gene is sugE [H]

Identifier: 46446349

GI number: 46446349

Start: 869993

End: 870325

Strand: Reverse

Name: sugE [H]

Synonym: pc0715

Alternate gene names: 46446349

Gene position: 870325-869993 (Counterclockwise)

Preceding gene: 46446350

Following gene: 46446348

Centisome position: 36.05

GC content: 33.03

Gene sequence:

>333_bases
TTGTTGAGATTTAATTTGGGCTGGATATATTTATTGATTGCTGGTTTATTTGAAATAGGGTTTACGACTTTTCTTAAGTT
GTCTAATAATTTTACTCGTCTATGGCCAACAGCTATTTTTTTTATTTTCTCGGTTTGCAGCTTTTTAGCACTTTCCTTAA
GCTTAAAAACTATTCCATTAGGAACAGCTTATGCTATTTGGACTGGCATGGGAGCAGTGGGAACAGCTGTGATTGGTATT
CTTTATTTTGGCGAGTCTATAGATTTTTGGCGTTTATTTTTTCTTGTCTGTCTTATTATTTCTATCATCGGACTTAAAAT
ATCTTCTGCATAA

Upstream 100 bases:

>100_bases
AAAATTTAGCTCTTGAAATTCTTTAAGGTTTAATCTATCAAATAATTCTTACAAAAAATTTTACCCGAGACATTACTTGT
AATTCTTTTTAACTATTTAC

Downstream 100 bases:

>100_bases
AACATTAATTAAATATTTAATTAAAATTTTTTTAGCTTAAATTTTTTGTATCTAAATACAAGTGAAAATTTAGAGTTGAA
GAACTTTTACAAATTTTTTA

Product: sugE protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MLRFNLGWIYLLIAGLFEIGFTTFLKLSNNFTRLWPTAIFFIFSVCSFLALSLSLKTIPLGTAYAIWTGMGAVGTAVIGI
LYFGESIDFWRLFFLVCLIISIIGLKISSA

Sequences:

>Translated_110_residues
MLRFNLGWIYLLIAGLFEIGFTTFLKLSNNFTRLWPTAIFFIFSVCSFLALSLSLKTIPLGTAYAIWTGMGAVGTAVIGI
LYFGESIDFWRLFFLVCLIISIIGLKISSA
>Mature_110_residues
MLRFNLGWIYLLIAGLFEIGFTTFLKLSNNFTRLWPTAIFFIFSVCSFLALSLSLKTIPLGTAYAIWTGMGAVGTAVIGI
LYFGESIDFWRLFFLVCLIISIIGLKISSA

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=44.2307692307692, Blast_Score=92, Evalue=8e-21,
Organism=Escherichia coli, GI1786755, Length=100, Percent_Identity=40, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12260; Mature: 12260

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFNLGWIYLLIAGLFEIGFTTFLKLSNNFTRLWPTAIFFIFSVCSFLALSLSLKTIPL
CCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTAYAIWTGMGAVGTAVIGILYFGESIDFWRLFFLVCLIISIIGLKISSA
CHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRFNLGWIYLLIAGLFEIGFTTFLKLSNNFTRLWPTAIFFIFSVCSFLALSLSLKTIPL
CCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTAYAIWTGMGAVGTAVIGILYFGESIDFWRLFFLVCLIISIIGLKISSA
CHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]