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The map label for this gene is ndk

Identifier: 46446002

GI number: 46446002

Start: 493528

End: 493959

Strand: Reverse

Name: ndk

Synonym: pc0368

Alternate gene names: 46446002

Gene position: 493959-493528 (Counterclockwise)

Preceding gene: 46446005

Following gene: 46446001

Centisome position: 20.46

GC content: 38.66

Gene sequence:

>432_bases
ATGACGTTAGAACGTACTCTTTCTATCATTAAGCCTGACGCAGTAGGTAACAATCACATTGGCGAAATCATTGCTCGCTT
TGAAAAAGCTGGTTTACGTATTGTTGCTGCAAAAATGAAACAATTAGATAGAAAAGATGCTGAAGGATTTTATGCTGTTC
ATAAAGGGCGCCCTTTCTTCGAAGATTTAGTTGGTTTTATGACAACGGGGCCTGTGATGATCATGGTCCTTGAAGGTGAA
AATGCCATCAATAAAAACCGTGAAATTATGGGAGCAACAGATCCTAAAAAAGCTGCTCCTGGAACAATTCGTGCAGATTT
TGCACAAACAATCGATGAAAATGCTGTTCACGGTTCTGATGCTGCGGAAACAGCAAAAACAGAAATTGAATACTTTTTTA
AATCTCAAGACGTTTGCGCAAGAAAACGTTAA

Upstream 100 bases:

>100_bases
ATTTTTTTGTAAGCTTTAGATATAGTTATTGGCATTCAAATAAAGATGGTCAAAACATAGAGTTGACTATGAGTTACACA
GAATCATTTAAGGAGATCTC

Downstream 100 bases:

>100_bases
ATCAGTATTGATGTGCTCCTTTTTATCGATAATTTTGATTCTTTTACTTATAATTTGGTCCAATACTTCCAAATGCTTGG
ATCTGATGTCAAAGTATTAA

Product: nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK 2; NDP kinase 2; Nucleoside-2-P kinase 2

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFFEDLVGFMTTGPVMIMVLEGE
NAINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSDAAETAKTEIEYFFKSQDVCARKR

Sequences:

>Translated_143_residues
MTLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFFEDLVGFMTTGPVMIMVLEGE
NAINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSDAAETAKTEIEYFFKSQDVCARKR
>Mature_142_residues
TLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFFEDLVGFMTTGPVMIMVLEGEN
AINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSDAAETAKTEIEYFFKSQDVCARKR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=141, Percent_Identity=42.5531914893617, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392205, Length=141, Percent_Identity=42.5531914893617, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4505409, Length=141, Percent_Identity=42.5531914893617, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392192, Length=141, Percent_Identity=42.5531914893617, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392203, Length=141, Percent_Identity=42.5531914893617, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=40.7407407407407, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=40, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=42.962962962963, Blast_Score=119, Evalue=6e-28,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=42.962962962963, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=40.2877697841727, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=40.2877697841727, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=35.036496350365, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI148839372, Length=135, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.8467153284672, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=55.2447552447552, Blast_Score=173, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=42.6470588235294, Blast_Score=130, Evalue=8e-32,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=42.6470588235294, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK2_PARUW (Q6MEA7)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007367.1
- ProteinModelPortal:   Q6MEA7
- SMR:   Q6MEA7
- STRING:   Q6MEA7
- GeneID:   2780636
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0368
- NMPDR:   fig|264201.1.peg.368
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- PhylomeDB:   Q6MEA7
- BioCyc:   CPRO264201:PC0368-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15815; Mature: 15684

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFF
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCHH
EDLVGFMTTGPVMIMVLEGENAINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
AAETAKTEIEYFFKSQDVCARKR
HHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure 
TLERTLSIIKPDAVGNNHIGEIIARFEKAGLRIVAAKMKQLDRKDAEGFYAVHKGRPFF
CHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCHH
EDLVGFMTTGPVMIMVLEGENAINKNREIMGATDPKKAAPGTIRADFAQTIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
AAETAKTEIEYFFKSQDVCARKR
HHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA