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The map label for this gene is gyrA [H]

Identifier: 46445985

GI number: 46445985

Start: 478308

End: 480209

Strand: Direct

Name: gyrA [H]

Synonym: pc0351

Alternate gene names: 46445985

Gene position: 478308-480209 (Clockwise)

Preceding gene: 46445984

Following gene: 46445986

Centisome position: 19.81

GC content: 34.54

Gene sequence:

>1902_bases
ATGGAAGATATTAAGCAATTGATGCAACGTCATTATATTAAATATGCCTCTTATGTCATTTTGGATAGGGCAATTCCTAA
TGTTATTGATGGGCTAAAGCCCGTACAGCGACGTATTCTCTATACTCTTTGGCTCATGCATGATGGCAAGCTTCATAAGG
TAGCAAATGTAGCAGGTCAGACAATGGCTCTACATCCTCATGGAGATGCGCCAATTACCGAGGCACTTATTAATATTGCT
AATAAAGGCTATTTGTTAGATCAGCAAGGAAATTTTGGTAATTTATTTACAGGAGATCCTGCCGCAGCAGCTCGTTATAT
TGAAACTCGTTTAACACCTTTAGCAAAAGAAACTTTATTTAATGCTGATTTGACCTCTACAATTCCCTCATATGATGGCA
GACATCAAGAACCTACTTGTCTTCCAGCCAAAATTCCCGTTGTCCTATTACAAGGCGCTGATGGAATTGCTGTAGGTATG
TCCACTCATATTTTCCCTCACAATTTTTTAGAACTTTTAGAAGCAGAAATTGCCATATTAGAAGGCAAACCTTTTTCTAT
TCTCCCTGATTTTCCAACCGGCGGCATTATGGATGCTTCTGACTACAATAAAGGAAAAGGAAAAGTTCGTTTGCGAGCAA
AAATTGAGGTAAGGGATGCTAAGTCTTTGGTTATTACTGAAATTTGTTATGGAACCACAACAGAATCTCTAATTCGATCA
ATTGATGAAGCCGCTAAAAAAGGTAAAATTAAAATTGATGCCATCAATGATTATACAGCAGAAAAAGTTGAAATTGAAAT
TAAGCTTCCACGTGGGCAATATGCTCAAGATTTATTAGAAGCTTTATATGCATATACTGAATGCCAAGTTACTCTACATT
CACAAATTGTGGTGATCAAAGACAATTATCCCTGGGAAACAGATGTCGATTCTATCTTACGGTTGCATACAGAAAAACTT
CAGGAATATTTACAAAGAGAACTAGAATTAGAACGCGATCATTTAAACGAAAAAATCTTCGAAAAAACTTTGGAGCAAAT
ATTTATTGAAAATCGGCTTTATAAGCGAATTGAAGATTTAACTTCTTACGAAGAAGTTCATGTAACGATTGCTGCAAGTT
TAATCCCTTTTCATTCTCAACTTTTAAGAATTCCTACAGAACAAGATAGAGAACGTTTACTCAGTATTCCCATTCGTCGT
ATTACGCGATTTGACTTAGCGAAAAATCAAGAGGAAATTTTATCTCACCAGGAGCAATTGACGCGTGTTGAAAAAGATCT
GAAAAATATCATTAAAGTAGCCATTCGTTATCTCAATAGTTTGATTAAAAAATTTGCAAGCGAACATAAGCGAAAAACAG
AAATTCAAGTAATTCAGCAAGTCGATACTCGTGCGATGGAAACAAGGCAAATTACTGTCTGTTTTGATCCTACAACTGGA
TTTATAGGAACTAAAGTCACTAGCAACTATACAATTGAGTGTACAAATTTTGATAAATTACTTGTAATATTCAAGGACGG
AACTTATCAAATCATCAATATTCCTGAAAAACAATATGTCCATCATAAGGGGAATAAAGTTGTTTATGTAGGTATAGCAG
ATAAAAAGACAATTATTAACGTCGTTTATCGAGATCCCGAAACTCACTATGTTTATGCAAAACGTTTTATTGTCGAAAAA
TTCATTTTAGATAAATATTACCGCTATTTGGAAGAAGGAACAACTTTGGAATTTATTTCTACACAACCTGGAGTTTCTTT
AGAATTACAATTTATTCCAAAACCTCGTCAAACTATTTCAAAAATGCAATTTCAAATCGATAATATAGCGGTAAAAGGGG
TGACAGCCAAAGGTATTCGCATATCAAACCGGGAAGTCAAAAAAGTTATTATTGCCAAATAA

Upstream 100 bases:

>100_bases
ATGAAATAGCTCCTGTATAGCAAGCGAATTTTTAAAAAATATGTAAATTAAGCATGAGATGAACTCTTTGATCAAGTTAT
CAAGATATTAGGAATAGCGC

Downstream 100 bases:

>100_bases
GCCATTGCAATGTGTTTTGATCTTTATAAAGCTCTTTGAAGGAGTTACGACCCTTTAGTTTATTGTGCTTGGATAAATAC
GAGAAAGAAAATTAAGAAAC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MEDIKQLMQRHYIKYASYVILDRAIPNVIDGLKPVQRRILYTLWLMHDGKLHKVANVAGQTMALHPHGDAPITEALINIA
NKGYLLDQQGNFGNLFTGDPAAAARYIETRLTPLAKETLFNADLTSTIPSYDGRHQEPTCLPAKIPVVLLQGADGIAVGM
STHIFPHNFLELLEAEIAILEGKPFSILPDFPTGGIMDASDYNKGKGKVRLRAKIEVRDAKSLVITEICYGTTTESLIRS
IDEAAKKGKIKIDAINDYTAEKVEIEIKLPRGQYAQDLLEALYAYTECQVTLHSQIVVIKDNYPWETDVDSILRLHTEKL
QEYLQRELELERDHLNEKIFEKTLEQIFIENRLYKRIEDLTSYEEVHVTIAASLIPFHSQLLRIPTEQDRERLLSIPIRR
ITRFDLAKNQEEILSHQEQLTRVEKDLKNIIKVAIRYLNSLIKKFASEHKRKTEIQVIQQVDTRAMETRQITVCFDPTTG
FIGTKVTSNYTIECTNFDKLLVIFKDGTYQIINIPEKQYVHHKGNKVVYVGIADKKTIINVVYRDPETHYVYAKRFIVEK
FILDKYYRYLEEGTTLEFISTQPGVSLELQFIPKPRQTISKMQFQIDNIAVKGVTAKGIRISNREVKKVIIAK

Sequences:

>Translated_633_residues
MEDIKQLMQRHYIKYASYVILDRAIPNVIDGLKPVQRRILYTLWLMHDGKLHKVANVAGQTMALHPHGDAPITEALINIA
NKGYLLDQQGNFGNLFTGDPAAAARYIETRLTPLAKETLFNADLTSTIPSYDGRHQEPTCLPAKIPVVLLQGADGIAVGM
STHIFPHNFLELLEAEIAILEGKPFSILPDFPTGGIMDASDYNKGKGKVRLRAKIEVRDAKSLVITEICYGTTTESLIRS
IDEAAKKGKIKIDAINDYTAEKVEIEIKLPRGQYAQDLLEALYAYTECQVTLHSQIVVIKDNYPWETDVDSILRLHTEKL
QEYLQRELELERDHLNEKIFEKTLEQIFIENRLYKRIEDLTSYEEVHVTIAASLIPFHSQLLRIPTEQDRERLLSIPIRR
ITRFDLAKNQEEILSHQEQLTRVEKDLKNIIKVAIRYLNSLIKKFASEHKRKTEIQVIQQVDTRAMETRQITVCFDPTTG
FIGTKVTSNYTIECTNFDKLLVIFKDGTYQIINIPEKQYVHHKGNKVVYVGIADKKTIINVVYRDPETHYVYAKRFIVEK
FILDKYYRYLEEGTTLEFISTQPGVSLELQFIPKPRQTISKMQFQIDNIAVKGVTAKGIRISNREVKKVIIAK
>Mature_633_residues
MEDIKQLMQRHYIKYASYVILDRAIPNVIDGLKPVQRRILYTLWLMHDGKLHKVANVAGQTMALHPHGDAPITEALINIA
NKGYLLDQQGNFGNLFTGDPAAAARYIETRLTPLAKETLFNADLTSTIPSYDGRHQEPTCLPAKIPVVLLQGADGIAVGM
STHIFPHNFLELLEAEIAILEGKPFSILPDFPTGGIMDASDYNKGKGKVRLRAKIEVRDAKSLVITEICYGTTTESLIRS
IDEAAKKGKIKIDAINDYTAEKVEIEIKLPRGQYAQDLLEALYAYTECQVTLHSQIVVIKDNYPWETDVDSILRLHTEKL
QEYLQRELELERDHLNEKIFEKTLEQIFIENRLYKRIEDLTSYEEVHVTIAASLIPFHSQLLRIPTEQDRERLLSIPIRR
ITRFDLAKNQEEILSHQEQLTRVEKDLKNIIKVAIRYLNSLIKKFASEHKRKTEIQVIQQVDTRAMETRQITVCFDPTTG
FIGTKVTSNYTIECTNFDKLLVIFKDGTYQIINIPEKQYVHHKGNKVVYVGIADKKTIINVVYRDPETHYVYAKRFIVEK
FILDKYYRYLEEGTTLEFISTQPGVSLELQFIPKPRQTISKMQFQIDNIAVKGVTAKGIRISNREVKKVIIAK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=368, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI19913406, Length=368, Percent_Identity=27.9891304347826, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1788562, Length=368, Percent_Identity=33.695652173913, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI1789396, Length=481, Percent_Identity=29.7297297297297, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535065, Length=320, Percent_Identity=28.125, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI212645845, Length=183, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=319, Percent_Identity=26.6457680250784, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=179, Percent_Identity=29.0502793296089, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=167, Percent_Identity=37.125748502994, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136538, Length=392, Percent_Identity=26.530612244898, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72611; Mature: 72611

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIKQLMQRHYIKYASYVILDRAIPNVIDGLKPVQRRILYTLWLMHDGKLHKVANVAGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
TMALHPHGDAPITEALINIANKGYLLDQQGNFGNLFTGDPAAAARYIETRLTPLAKETLF
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHC
NADLTSTIPSYDGRHQEPTCLPAKIPVVLLQGADGIAVGMSTHIFPHNFLELLEAEIAIL
CCCHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHHHEEE
EGKPFSILPDFPTGGIMDASDYNKGKGKVRLRAKIEVRDAKSLVITEICYGTTTESLIRS
CCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEHHHCCCCHHHHHHH
IDEAAKKGKIKIDAINDYTAEKVEIEIKLPRGQYAQDLLEALYAYTECQVTLHSQIVVIK
HHHHHHCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEEEEEEE
DNYPWETDVDSILRLHTEKLQEYLQRELELERDHLNEKIFEKTLEQIFIENRLYKRIEDL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSYEEVHVTIAASLIPFHSQLLRIPTEQDRERLLSIPIRRITRFDLAKNQEEILSHQEQL
CCHHHEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TRVEKDLKNIIKVAIRYLNSLIKKFASEHKRKTEIQVIQQVDTRAMETRQITVCFDPTTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
FIGTKVTSNYTIECTNFDKLLVIFKDGTYQIINIPEKQYVHHKGNKVVYVGIADKKTIIN
CEECEECCCEEEEEECCCEEEEEEECCCEEEEECCHHHHHHCCCCEEEEEEECCCCEEEE
VVYRDPETHYVYAKRFIVEKFILDKYYRYLEEGTTLEFISTQPGVSLELQFIPKPRQTIS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCHHHHH
KMQFQIDNIAVKGVTAKGIRISNREVKKVIIAK
HHHHEEEEEEEECEEECCEEECCCCEEEEEECC
>Mature Secondary Structure
MEDIKQLMQRHYIKYASYVILDRAIPNVIDGLKPVQRRILYTLWLMHDGKLHKVANVAGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
TMALHPHGDAPITEALINIANKGYLLDQQGNFGNLFTGDPAAAARYIETRLTPLAKETLF
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHC
NADLTSTIPSYDGRHQEPTCLPAKIPVVLLQGADGIAVGMSTHIFPHNFLELLEAEIAIL
CCCHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHHHEEE
EGKPFSILPDFPTGGIMDASDYNKGKGKVRLRAKIEVRDAKSLVITEICYGTTTESLIRS
CCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEHHHCCCCHHHHHHH
IDEAAKKGKIKIDAINDYTAEKVEIEIKLPRGQYAQDLLEALYAYTECQVTLHSQIVVIK
HHHHHHCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEEEEEEE
DNYPWETDVDSILRLHTEKLQEYLQRELELERDHLNEKIFEKTLEQIFIENRLYKRIEDL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSYEEVHVTIAASLIPFHSQLLRIPTEQDRERLLSIPIRRITRFDLAKNQEEILSHQEQL
CCHHHEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TRVEKDLKNIIKVAIRYLNSLIKKFASEHKRKTEIQVIQQVDTRAMETRQITVCFDPTTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
FIGTKVTSNYTIECTNFDKLLVIFKDGTYQIINIPEKQYVHHKGNKVVYVGIADKKTIIN
CEECEECCCEEEEEECCCEEEEEEECCCEEEEECCHHHHHHCCCCEEEEEEECCCCEEEE
VVYRDPETHYVYAKRFIVEKFILDKYYRYLEEGTTLEFISTQPGVSLELQFIPKPRQTIS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCHHHHH
KMQFQIDNIAVKGVTAKGIRISNREVKKVIIAK
HHHHEEEEEEEECEEECCEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]