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The map label for this gene is mutY [H]

Identifier: 46445723

GI number: 46445723

Start: 149879

End: 150937

Strand: Direct

Name: mutY [H]

Synonym: pc0089

Alternate gene names: 46445723

Gene position: 149879-150937 (Clockwise)

Preceding gene: 46445722

Following gene: 46445724

Centisome position: 6.21

GC content: 35.32

Gene sequence:

>1059_bases
ATGTCTTCTTCTTTCCCTAATGAAAAATTAAAAAAATGGTTCCTGTCTTCAAAAAGAGATCTACCTTGGAGACAAAATCC
AACACCTTATGCAGTTTGGATTTCTGAGGTCATGCTGCAGCAAACGCAAGTTGCCGTTGTCATTCCCTATTTTAATCGTT
GGATGCAAGCATTTCCCTCTATTGAAGCTTTAGCTATAGCATCTTTAGAAGAAGTAATTAAAGCTTGGGAAGGGCTTGGA
TATTACTCGCGAGCGCGTCATTTACATCAAGGAGCTCAATATTTAGTTGAACATTGCCAAGGTGAACTTCCAGCAGATGA
AAAGGAATTAAAAAAAATTAAAGGACTAGGACCTTATACTATTGGAGCTATCTTAAGTTTTGCTTTTCATCAAAAAAAAG
CAGCTGTTGATGGAAATGTTTTACGTGTTTTAGCTAGATATTTTCAAATTGAAGAAGATATCGCGAAAACTTCCACGATA
AAAAAATTGCGGGATTTTGCAGAATCTATTTTGCCAGATGAAGAGTCTTGGATATCTTCTGAGGCTTTAATTGAATTGGG
AGCGACAATTTGTAGCCGTAAAGCGATATGTCAGGAATGTCCATTAAAAAGTAATTGTCAAAGTTATTTGCATGGATTAA
GCGATAAACTTCCTATTAAAACGAAGGCAATTAAAACACAATATTTGTATAGAGCTGTTGCGATAGTGAAATGTGGGGAT
TATTTTTTAGTAAAAAAAGGAAAAAAAGGAGAAATTATGTCCGATCTTTACGAGTTTCCCTTTTTTGAAGTCTCTCAAGA
GGGAATTACATTTAAAGAATTACAAGAAAATATCAAGTTGCATTGGAATTTAACTGTACATCTTTTGCAATCACTATCCT
CTATTGAACACGGCTTTACTCGTTATCAAGCGAGGTTAGACCCTTGTGTTTTCAATTGTCTAGAAATGTCTCCTGTAAAA
GATCTGGAATGGCTAGATACGAAGTCTCTTAAGCAGAAAGCTTTTTCTTCAGGTCACCGTCGCATTTTTCAGAGCCTTCT
TTCTTTAGATATCGATTAA

Upstream 100 bases:

>100_bases
TTACAAGTAAATGAAAAAAAATTTATTTACTTGTTTATTGTTTCCAAACACAATAATTTATTTATTCACTCACTAATCTA
CTTAGCTTTGATTCTTTTTA

Downstream 100 bases:

>100_bases
TTTCAGCAAGTTTTAAATATTTATAAAAGGCTGTTGAGCCATTATAAAAACTGATTTCGAATCCCTCCTGCCCATCTAAA
AAGCCTCTTTTAATAATATA

Product: putative A/G-specific adenine glycosylase, mutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSSSFPNEKLKKWFLSSKRDLPWRQNPTPYAVWISEVMLQQTQVAVVIPYFNRWMQAFPSIEALAIASLEEVIKAWEGLG
YYSRARHLHQGAQYLVEHCQGELPADEKELKKIKGLGPYTIGAILSFAFHQKKAAVDGNVLRVLARYFQIEEDIAKTSTI
KKLRDFAESILPDEESWISSEALIELGATICSRKAICQECPLKSNCQSYLHGLSDKLPIKTKAIKTQYLYRAVAIVKCGD
YFLVKKGKKGEIMSDLYEFPFFEVSQEGITFKELQENIKLHWNLTVHLLQSLSSIEHGFTRYQARLDPCVFNCLEMSPVK
DLEWLDTKSLKQKAFSSGHRRIFQSLLSLDID

Sequences:

>Translated_352_residues
MSSSFPNEKLKKWFLSSKRDLPWRQNPTPYAVWISEVMLQQTQVAVVIPYFNRWMQAFPSIEALAIASLEEVIKAWEGLG
YYSRARHLHQGAQYLVEHCQGELPADEKELKKIKGLGPYTIGAILSFAFHQKKAAVDGNVLRVLARYFQIEEDIAKTSTI
KKLRDFAESILPDEESWISSEALIELGATICSRKAICQECPLKSNCQSYLHGLSDKLPIKTKAIKTQYLYRAVAIVKCGD
YFLVKKGKKGEIMSDLYEFPFFEVSQEGITFKELQENIKLHWNLTVHLLQSLSSIEHGFTRYQARLDPCVFNCLEMSPVK
DLEWLDTKSLKQKAFSSGHRRIFQSLLSLDID
>Mature_351_residues
SSSFPNEKLKKWFLSSKRDLPWRQNPTPYAVWISEVMLQQTQVAVVIPYFNRWMQAFPSIEALAIASLEEVIKAWEGLGY
YSRARHLHQGAQYLVEHCQGELPADEKELKKIKGLGPYTIGAILSFAFHQKKAAVDGNVLRVLARYFQIEEDIAKTSTIK
KLRDFAESILPDEESWISSEALIELGATICSRKAICQECPLKSNCQSYLHGLSDKLPIKTKAIKTQYLYRAVAIVKCGDY
FLVKKGKKGEIMSDLYEFPFFEVSQEGITFKELQENIKLHWNLTVHLLQSLSSIEHGFTRYQARLDPCVFNCLEMSPVKD
LEWLDTKSLKQKAFSSGHRRIFQSLLSLDID

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=209, Percent_Identity=44.4976076555024, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI115298650, Length=209, Percent_Identity=44.4976076555024, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI115298654, Length=209, Percent_Identity=44.4976076555024, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI115298652, Length=209, Percent_Identity=44.4976076555024, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI190358497, Length=209, Percent_Identity=44.4976076555024, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI6912520, Length=209, Percent_Identity=44.4976076555024, Blast_Score=178, Evalue=6e-45,
Organism=Escherichia coli, GI1789331, Length=312, Percent_Identity=35.2564102564103, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40367; Mature: 40236

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSFPNEKLKKWFLSSKRDLPWRQNPTPYAVWISEVMLQQTQVAVVIPYFNRWMQAFPS
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCC
IEALAIASLEEVIKAWEGLGYYSRARHLHQGAQYLVEHCQGELPADEKELKKIKGLGPYT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHH
IGAILSFAFHQKKAAVDGNVLRVLARYFQIEEDIAKTSTIKKLRDFAESILPDEESWISS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EALIELGATICSRKAICQECPLKSNCQSYLHGLSDKLPIKTKAIKTQYLYRAVAIVKCGD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
YFLVKKGKKGEIMSDLYEFPFFEVSQEGITFKELQENIKLHWNLTVHLLQSLSSIEHGFT
EEEEECCCCCCHHHHHHHCCCHHHCCCCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
RYQARLDPCVFNCLEMSPVKDLEWLDTKSLKQKAFSSGHRRIFQSLLSLDID
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSSFPNEKLKKWFLSSKRDLPWRQNPTPYAVWISEVMLQQTQVAVVIPYFNRWMQAFPS
CCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCC
IEALAIASLEEVIKAWEGLGYYSRARHLHQGAQYLVEHCQGELPADEKELKKIKGLGPYT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHH
IGAILSFAFHQKKAAVDGNVLRVLARYFQIEEDIAKTSTIKKLRDFAESILPDEESWISS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EALIELGATICSRKAICQECPLKSNCQSYLHGLSDKLPIKTKAIKTQYLYRAVAIVKCGD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
YFLVKKGKKGEIMSDLYEFPFFEVSQEGITFKELQENIKLHWNLTVHLLQSLSSIEHGFT
EEEEECCCCCCHHHHHHHCCCHHHCCCCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
RYQARLDPCVFNCLEMSPVKDLEWLDTKSLKQKAFSSGHRRIFQSLLSLDID
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]