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The map label for this gene is cobT

Identifier: 45659175

GI number: 45659175

Start: 4114237

End: 4115271

Strand: Direct

Name: cobT

Synonym: LIC13356

Alternate gene names: 45659175

Gene position: 4114237-4115271 (Clockwise)

Preceding gene: 45659174

Following gene: 45659176

Centisome position: 96.19

GC content: 36.71

Gene sequence:

>1035_bases
TTGAACCCAGACCAACTTTCTACAAAACTACAAAACAAGATTGATCTAAAAACAAAACCTCCAGGCTCTTTAGGAACGCT
TGAATCAATCGCGCTTCAAATAGGCTTGATTCAAAATACTGATTCTCCAGAATTAAAAAACCCTCATATTCTTGTTTTTG
CAGGTGATCATGGTCTTGCCGAATCCGGAGTCAGCGCTTTTCCAAAAGAAGTCACCCACCAAATGGTATTCAATTTTTTG
AATGGAGGAGCAGCCATCAACGCATTCTGCAAACAAAATTCTATTCGACTTAAAGTGGTGGACTCGGGAGTAGATTTTAA
ATTTCCTCATGATACAGTTTCTCTTCATCCTGATTTTATAGACGCCAAAGTTGGATTTGGAACTAAAAACATTTTGATTG
AACCTGCTATGACAAAAGAGCAATGCAATCAAGCTTTAGAAAACGGAGCCAGAATTTCCCAAAAATCAGTATCAGAAAAT
TGTAATGTAATCGGGTTTGGAGAAATGGGAATTGGAAACACTTCTTCAGCAAGTCTTATTACTGCAAGTATTTTAAAAAA
AAGCTTAAAAGAAGTTACAGGAAAAGGAACCGGATTAAATGATCAGGGATTTCAGAAAAAAATTGAGATTTTAGAGAAAT
GTTTCGAAAAACATAAAACCAATTTGAAAACCGCTTTTGACGTTTTACAAACGTTCGGAGGGTTTGAAATCGCCATGATG
GTAGGGGCTATGATCGATTCTGTAAAAAAAGGAAGAATCATTTTAATAGATGGATTTATCGCGACTTCGGCTTTCTTGAT
TGCTCATAAAATGGAACCTTCCATTCTAAAAAATGCGGTCTTTTGTCATAAATCTGTCGAACCCGGTCATTCTTATTTAT
TAGAAGAATGGAATATAAAGCCCCTTCTTGATTTAGGACTCAGACTCGGAGAAGGAACCGGATGTGCAATTGCATTTCCG
ATTCTTATATCCGCTGTGACTTTCTTAAAAGAAATGGCCTCTTTCGAGTCCGCAAAAGTGGATCAAAAACTTTGA

Upstream 100 bases:

>100_bases
GAATCGATATTTTTAACAACTGAATCTTTTAGCATTTGTATAGATTTTGACAAGGGCGGATTTTTATAACTTTTACAAAA
ACTAATATAGGAGTTTCCCT

Downstream 100 bases:

>100_bases
ATAAACTCCAAGAAGAATGGAACCGTTTCTGTGCTTCTTGGATGTTCAATACGAGACTTCCAATTCTTCCATTTTACGTT
TATTCTGAATCTACACTTTC

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLAESGVSAFPKEVTHQMVFNFL
NGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFIDAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSEN
CNVIGFGEMGIGNTSSASLITASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMM
VGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIKPLLDLGLRLGEGTGCAIAFP
ILISAVTFLKEMASFESAKVDQKL

Sequences:

>Translated_344_residues
MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLAESGVSAFPKEVTHQMVFNFL
NGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFIDAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSEN
CNVIGFGEMGIGNTSSASLITASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMM
VGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIKPLLDLGLRLGEGTGCAIAFP
ILISAVTFLKEMASFESAKVDQKL
>Mature_344_residues
MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLAESGVSAFPKEVTHQMVFNFL
NGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFIDAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSEN
CNVIGFGEMGIGNTSSASLITASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMM
VGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIKPLLDLGLRLGEGTGCAIAFP
ILISAVTFLKEMASFESAKVDQKL

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=334, Percent_Identity=30.8383233532934, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_LEPIC (Q72M35)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_003261.1
- ProteinModelPortal:   Q72M35
- SMR:   Q72M35
- GeneID:   2771052
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC13356
- NMPDR:   fig|267671.1.peg.3261
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   LINT267671:LIC_13356-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 37250; Mature: 37250

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: ACT_SITE 311-311

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCH
ESGVSAFPKEVTHQMVFNFLNGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFI
HCCHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCEEEEEEECCCCCCCCCCCEEECCCEE
DAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSENCNVIGFGEMGIGNTSSASLI
EEECCCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHH
TASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
VGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIK
HHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PLLDLGLRLGEGTGCAIAFPILISAVTFLKEMASFESAKVDQKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNPDQLSTKLQNKIDLKTKPPGSLGTLESIALQIGLIQNTDSPELKNPHILVFAGDHGLA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCH
ESGVSAFPKEVTHQMVFNFLNGGAAINAFCKQNSIRLKVVDSGVDFKFPHDTVSLHPDFI
HCCHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCEEEEEEECCCCCCCCCCCEEECCCEE
DAKVGFGTKNILIEPAMTKEQCNQALENGARISQKSVSENCNVIGFGEMGIGNTSSASLI
EEECCCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHH
TASILKKSLKEVTGKGTGLNDQGFQKKIEILEKCFEKHKTNLKTAFDVLQTFGGFEIAMM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
VGAMIDSVKKGRIILIDGFIATSAFLIAHKMEPSILKNAVFCHKSVEPGHSYLLEEWNIK
HHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PLLDLGLRLGEGTGCAIAFPILISAVTFLKEMASFESAKVDQKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA