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The map label for this gene is rnD

Identifier: 45659084

GI number: 45659084

Start: 4001129

End: 4002295

Strand: Direct

Name: rnD

Synonym: LIC13263

Alternate gene names: 45659084

Gene position: 4001129-4002295 (Clockwise)

Preceding gene: 45659081

Following gene: 45659085

Centisome position: 93.55

GC content: 35.39

Gene sequence:

>1167_bases
ATGCAAATAAATTCCGATTACATAGTCGTTGACACAGCTCGAAGCCTACAACTAGTCCTCATCAATCTGAGTCAGGCGGA
TTCTATTTCCGTAGATACAGAGTCCTCAGGTTATTATACGTATTTTTCTAAGGTATGTCTGATTCAAATTTCCGCTAAAG
GAAAAAATTACATCATTGATCCTTTAAAGTTACAGAATTTAGAAAGTCTTGGAAACTTATTTGAAGATAAAAAAATCCTA
AAAATATTTCATTCTGCTATCGACGACATTAAAGCTCTCAAGAAAGATTTCGGTTTTCAATTTCAAAATATCGCGGATAC
AGGATTTAGTTCTCGTCTTCTGGATCATGAACAATATTCCCTAACGTATCTTGTGGATTACTATCACAAGATTAAACTTT
CCAAGAAGGAACAAAAATCCAATTGGGAAAAAAGGCCTCTCGAAAAAAGCCAACTTCAATATGCAGCCTTAGATACGGTT
TATCTGGAAACGATTTGGGAAAAAATGAAGGAAGAGCTTATCAAAAGAAATCTTTACGAAGAAGCAATTTCCGAATTTGA
AAAGATCGCTTCTGAAGAACCAGGCTCTGAAGGAAATTCTATATCTATGGATAAGTTTCCGGAGATTTTGGAATATAGCG
CAGACGAAAGAAGATTTATATACGACACATTGGTTTTCAGGGACGATAAATCTAGAAAGTTAAACAAGGCGCCTTTTAGA
GTATTTAATAATGAGAAAGTAGTTCTACTCATGAAAGCAAGAAGAGATATGAAAAAGTTAACCGAAATCGTAGGTAAAAA
AGACGCAGAAACACTTTTTCAAATCTATGCAAATCCTAGCGGACCTCCGATCCAAAAGTCAGAGCTTTTTAAAAAACCGG
GAGAAAACCTTACCAACGAAGAAGGAGAACGTTTCAAACGTCTGAGAATTTGGAGAGAGACAATCATGTCGATACGAAGA
ATGAGTCATCAGATGATGCCTTCTAACAAGATGATTGCAGAACTCTCTCAAAAAAATCCAAAAACCTTAGACGAATTGAG
GAAAATGAATCTTTTTTCGGAATGGAAAGTGATACACTACGGCCCGTCTATATTAGCGGCTTTAGAAAACGTACCTTACG
AATCGAATATCAAAGGTTTGATTCCAATTAATAAAAAGTTCGAATAA

Upstream 100 bases:

>100_bases
TTTGGTTTGTCATCCTGGGCTTGTCTTCTTATTCTGGATTTATCGGGAATTCGACTCATTCTCTGCCTTCTTAAGCTTAA
AATCTCAGGTTGCGTTTTTC

Downstream 100 bases:

>100_bases
ATAAATTCTAATATTTGAATATACCTTAAGAATGCGATTGGACTTTCAATCACTCAAAGAACGCCTTATAATCCCTCAGG
AAAATTTTATAGGAATTCCA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQINSDYIVVDTARSLQLVLINLSQADSISVDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLESLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFQFQNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELIKRNLYEEAISEFEKIASEEPGSEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVVLLMKARRDMKKLTEIVGKKDAETLFQIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELSQKNPKTLDELRKMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE

Sequences:

>Translated_388_residues
MQINSDYIVVDTARSLQLVLINLSQADSISVDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLESLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFQFQNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELIKRNLYEEAISEFEKIASEEPGSEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVVLLMKARRDMKKLTEIVGKKDAETLFQIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELSQKNPKTLDELRKMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE
>Mature_388_residues
MQINSDYIVVDTARSLQLVLINLSQADSISVDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLESLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFQFQNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELIKRNLYEEAISEFEKIASEEPGSEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVVLLMKARRDMKKLTEIVGKKDAETLFQIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELSQKNPKTLDELRKMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=164, Percent_Identity=36.5853658536585, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI50301240, Length=164, Percent_Identity=36.5853658536585, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788105, Length=184, Percent_Identity=27.1739130434783, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17531757, Length=181, Percent_Identity=30.939226519337, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564304, Length=105, Percent_Identity=30.4761904761905, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=184, Percent_Identity=35.8695652173913, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161078302, Length=174, Percent_Identity=33.9080459770115, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 45342; Mature: 45342

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINSDYIVVDTARSLQLVLINLSQADSISVDTESSGYYTYFSKVCLIQISAKGKNYIID
CCCCCCEEEEECCCCEEEEEEEECCCCCEEEECCCCCCHHEEEEEEEEEEECCCCCEEEC
PLKLQNLESLGNLFEDKKILKIFHSAIDDIKALKKDFGFQFQNIADTGFSSRLLDHEQYS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHCCCHHHHHHCCHHHH
LTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTVYLETIWEKMKEELIKRNLYE
HHHHHHHHHHHHCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAISEFEKIASEEPGSEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHEEECCCCCCCCCCCCE
VFNNEKVVLLMKARRDMKKLTEIVGKKDAETLFQIYANPSGPPIQKSELFKKPGENLTNE
EECCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCH
EGERFKRLRIWRETIMSIRRMSHQMMPSNKMIAELSQKNPKTLDELRKMNLFSEWKVIHY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCHHHCCEEEEE
GPSILAALENVPYESNIKGLIPINKKFE
CHHHHHHHHCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MQINSDYIVVDTARSLQLVLINLSQADSISVDTESSGYYTYFSKVCLIQISAKGKNYIID
CCCCCCEEEEECCCCEEEEEEEECCCCCEEEECCCCCCHHEEEEEEEEEEECCCCCEEEC
PLKLQNLESLGNLFEDKKILKIFHSAIDDIKALKKDFGFQFQNIADTGFSSRLLDHEQYS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHCCCHHHHHHCCHHHH
LTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTVYLETIWEKMKEELIKRNLYE
HHHHHHHHHHHHCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAISEFEKIASEEPGSEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHEEECCCCCCCCCCCCE
VFNNEKVVLLMKARRDMKKLTEIVGKKDAETLFQIYANPSGPPIQKSELFKKPGENLTNE
EECCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCH
EGERFKRLRIWRETIMSIRRMSHQMMPSNKMIAELSQKNPKTLDELRKMNLFSEWKVIHY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCHHHCCEEEEE
GPSILAALENVPYESNIKGLIPINKKFE
CHHHHHHHHCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]