Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 45659027

GI number: 45659027

Start: 3933618

End: 3934544

Strand: Direct

Name: czcD [H]

Synonym: LIC13205

Alternate gene names: 45659027

Gene position: 3933618-3934544 (Clockwise)

Preceding gene: 45659022

Following gene: 45659032

Centisome position: 91.97

GC content: 37.86

Gene sequence:

>927_bases
ATGGGACATCATCATTCGCATAACCATTCTCACGATCATTCCCACAATCCCCATTCTGAAAATGCGGGTAAAAGTCTTGT
GATCGCAATGATCTTTAACCTAGTTTATGCCGGGATCGAAGCCGGAATCGGCCTAACGTCCGGATCTCTTGCCTTACTTT
CAGATGCGGGTCATAACTTAATGGACGTAAGTTCTTTGTTACTGGCCTGGATCGCAATTAAATTGCAGGAAAAAAAACCA
TTTCCCGGATTTACTTACGGTTGGAAAAAATCTACAATTTTAGTAAGTCTACTCAATTCCATTCTCATTTTTGGAACCGT
GGGTTTAATTGTATACGAATCGATCGAAAAGTTATCTAAACCTAGTTCCGTTCCGGGTGGCATGATCGCCGCAGTGGCGT
TTGTAGGTGTTTTAGTAAATTTTTCTTCTTCTTTTTTATTTCATAAAAGTAAAGACCAAGACATCAACATGAAAGGCGCT
TATTTACACCTTCTCGCGGACGGATTAGTATCCTTGGGAGTAATCATTTCCGGTTTGTTGATCCAGTGGCTCGGATTTTT
TTGGATCGATCCAGTTGTTGGTCTTTTAGTAGGATTGGTAATTCTTTATGGTAATATTCCGCTGTTTAGGCAAAGCCTAA
GATTAAGTTTGGATTCCACACCAGAAACGATCCAATCTGGAATCGTAGAAAAGGAACTCAAATCTATAGAAGGTGTATTA
AATATTCATCATATTCATATTTGGTCTTTAAGTACAACCGAAAATGCACTTACCGCACACCTCGTTTTAAAAAATGACCT
TACTTTTGAACATCAGAGAATTATAAAGTCCAAGGCAAGAGAAATTTTAAAAGGTTTAAAAATCGAACACGTCACATTAG
AAACAGAAGAAGAAAGAGAAAACTGCGAACAAATTGATTGTAATTGA

Upstream 100 bases:

>100_bases
ATTTTCCTTCTAGAGAATCGATTCTCAACAAAGAGCCTATTTTTCAGTTTACAAACCCGTAGCTTCTCTAATCTGAGAAT
GGTATCGTTTTCAAAAACTC

Downstream 100 bases:

>100_bases
TATTTCTCATCAGGACCAAATCTTTCACTTTAAAACATTCAATTATTATAATATATAGAAAATTCGCCGTAAAAAATCCA
TGATTCATTTTTCTAAAAAA

Product: heavy metal efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGHHHSHNHSHDHSHNPHSENAGKSLVIAMIFNLVYAGIEAGIGLTSGSLALLSDAGHNLMDVSSLLLAWIAIKLQEKKP
FPGFTYGWKKSTILVSLLNSILIFGTVGLIVYESIEKLSKPSSVPGGMIAAVAFVGVLVNFSSSFLFHKSKDQDINMKGA
YLHLLADGLVSLGVIISGLLIQWLGFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGIVEKELKSIEGVL
NIHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAREILKGLKIEHVTLETEEERENCEQIDCN

Sequences:

>Translated_308_residues
MGHHHSHNHSHDHSHNPHSENAGKSLVIAMIFNLVYAGIEAGIGLTSGSLALLSDAGHNLMDVSSLLLAWIAIKLQEKKP
FPGFTYGWKKSTILVSLLNSILIFGTVGLIVYESIEKLSKPSSVPGGMIAAVAFVGVLVNFSSSFLFHKSKDQDINMKGA
YLHLLADGLVSLGVIISGLLIQWLGFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGIVEKELKSIEGVL
NIHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAREILKGLKIEHVTLETEEERENCEQIDCN
>Mature_307_residues
GHHHSHNHSHDHSHNPHSENAGKSLVIAMIFNLVYAGIEAGIGLTSGSLALLSDAGHNLMDVSSLLLAWIAIKLQEKKPF
PGFTYGWKKSTILVSLLNSILIFGTVGLIVYESIEKLSKPSSVPGGMIAAVAFVGVLVNFSSSFLFHKSKDQDINMKGAY
LHLLADGLVSLGVIISGLLIQWLGFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGIVEKELKSIEGVLN
IHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAREILKGLKIEHVTLETEEERENCEQIDCN

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=320, Percent_Identity=23.125, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI20070323, Length=320, Percent_Identity=24.6875, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI289803013, Length=317, Percent_Identity=25.5520504731861, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803009, Length=317, Percent_Identity=25.5520504731861, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803007, Length=317, Percent_Identity=25.5520504731861, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803003, Length=317, Percent_Identity=25.5520504731861, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI64762489, Length=317, Percent_Identity=25.5520504731861, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI21361112, Length=336, Percent_Identity=23.2142857142857, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI21359890, Length=311, Percent_Identity=22.8295819935691, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI14210520, Length=229, Percent_Identity=21.8340611353712, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI222080086, Length=142, Percent_Identity=26.056338028169, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40255009, Length=142, Percent_Identity=26.056338028169, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52351208, Length=184, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=292, Percent_Identity=31.8493150684932, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193210990, Length=330, Percent_Identity=26.3636363636364, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=327, Percent_Identity=23.8532110091743, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=304, Percent_Identity=26.9736842105263, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17555796, Length=321, Percent_Identity=23.3644859813084, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324892, Length=170, Percent_Identity=31.7647058823529, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=156, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=34.6590909090909, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656728, Length=329, Percent_Identity=22.4924012158055, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656724, Length=329, Percent_Identity=22.4924012158055, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656720, Length=329, Percent_Identity=22.4924012158055, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656715, Length=329, Percent_Identity=22.4924012158055, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357035, Length=329, Percent_Identity=22.4924012158055, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583858, Length=356, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585900, Length=113, Percent_Identity=30.0884955752212, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585898, Length=113, Percent_Identity=30.0884955752212, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585896, Length=113, Percent_Identity=30.0884955752212, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921672, Length=113, Percent_Identity=30.0884955752212, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574430, Length=159, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24584409, Length=159, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33871; Mature: 33740

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHHHSHNHSHDHSHNPHSENAGKSLVIAMIFNLVYAGIEAGIGLTSGSLALLSDAGHNL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCH
MDVSSLLLAWIAIKLQEKKPFPGFTYGWKKSTILVSLLNSILIFGTVGLIVYESIEKLSK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSSVPGGMIAAVAFVGVLVNFSSSFLFHKSKDQDINMKGAYLHLLADGLVSLGVIISGLL
CCCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IQWLGFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGIVEKELKSIEGVL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAREILKGLKIEHVTLETEEERE
EEEEEEEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
NCEQIDCN
HHHCCCCC
>Mature Secondary Structure 
GHHHSHNHSHDHSHNPHSENAGKSLVIAMIFNLVYAGIEAGIGLTSGSLALLSDAGHNL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCH
MDVSSLLLAWIAIKLQEKKPFPGFTYGWKKSTILVSLLNSILIFGTVGLIVYESIEKLSK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSSVPGGMIAAVAFVGVLVNFSSSFLFHKSKDQDINMKGAYLHLLADGLVSLGVIISGLL
CCCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IQWLGFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGIVEKELKSIEGVL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAREILKGLKIEHVTLETEEERE
EEEEEEEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
NCEQIDCN
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]