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The map label for this gene is galE [H]

Identifier: 45658975

GI number: 45658975

Start: 3865744

End: 3866715

Strand: Reverse

Name: galE [H]

Synonym: LIC13153

Alternate gene names: 45658975

Gene position: 3866715-3865744 (Counterclockwise)

Preceding gene: 45658976

Following gene: 45658973

Centisome position: 90.4

GC content: 40.43

Gene sequence:

>972_bases
GTGAGGTTATTGATTACCGGAGGCGCCGGTTATATAGGAAGTCACGTAGTTGCCCTTCTTCTTGAAAAAAAACACGAACT
TGTAATCGTAGATAATCTAGAAAAAGGGAACAGATCTAATCTTTTTTCTGAAACACAATTGATTCAGGGGAATATCCAAG
ACGAATCTGTGTTGGAAAATGCATTTTCAAAACCTATCGACGCGGTTTTTCATTTTGCTGCATGGAAGGCTGCGGGCGAA
TCTATGACCGATCCTTCTAAATATGCTCTGAATAATATCAACGGAACTCTCAAACTTCTTACTTTTATGGAAAAGGCCGG
AACGAATCAGTTTATCTTTTCTTCCTCGGCGGCTGTTTATGGTTCTCCGGAATATCTTCCTATTGATGAGAAACACCCCG
TTCGTCCGGAAAATTATTACGGTTATACAAAACTTGCGATCGAACAGAATTTAAAATGGTACGAAACTCTCAAAGGATTT
AAATTTGCTGCATTACGTTATTTTAATGCTGCTGGTTATGATCCAAAAGGAAGAGTTCGAGGATTAGAAAGAACTCCTGC
AAATCTTCTTCCTATTATTATGGAAGCCGCAGTAGGGATAAGAAAAGATTTTGAGGTGTTTGGCACGGATTATGAAACTC
CGGATGGAAGTTGTGTACGCGATTATATTCATGTGACCGACTTGGCAAAGGCGCACGTTTTGAGTTTGGATTATCTAGAT
TCTGAAAAGAAATCTCTCACGGTCAATTTAGGTTCTGAAAAGGGATATTCCGTTTTAGAAATGGTTCGTCTTGCGGAGGA
GGTGGTCGGAAGATCGATTCCTCATAAAATTTCGGGAAGAAGGGCTGGAGATCCCGCAAAACTTTTGGCTTCTTCTGCAA
TGGCTCAACGTTTATTACAATGGGTCCCAGAATACAGTGAGGCCAAAACACTTCTTAAAACGATGTGGGACGTATATCAA
AATCCGGCTTAG

Upstream 100 bases:

>100_bases
AAGCTTTGGACGAATTGGAAGCTTCTGGAAACTTAATTGAACAAGTTAAGTATATTATAAAATTCTTTAGAGATAGTGAT
CGGGGAGTTACAAATCACAG

Downstream 100 bases:

>100_bases
TCAACGAATTGATTTACATTCTGGATTGATCGAAGTCACGTATTCCAAGGGAAGGTTTTGTAAAAATTCTCCTCCTGAAA
ATTTTCCTTTAAATTGAATT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRLLITGGAGYIGSHVVALLLEKKHELVIVDNLEKGNRSNLFSETQLIQGNIQDESVLENAFSKPIDAVFHFAAWKAAGE
SMTDPSKYALNNINGTLKLLTFMEKAGTNQFIFSSSAAVYGSPEYLPIDEKHPVRPENYYGYTKLAIEQNLKWYETLKGF
KFAALRYFNAAGYDPKGRVRGLERTPANLLPIIMEAAVGIRKDFEVFGTDYETPDGSCVRDYIHVTDLAKAHVLSLDYLD
SEKKSLTVNLGSEKGYSVLEMVRLAEEVVGRSIPHKISGRRAGDPAKLLASSAMAQRLLQWVPEYSEAKTLLKTMWDVYQ
NPA

Sequences:

>Translated_323_residues
MRLLITGGAGYIGSHVVALLLEKKHELVIVDNLEKGNRSNLFSETQLIQGNIQDESVLENAFSKPIDAVFHFAAWKAAGE
SMTDPSKYALNNINGTLKLLTFMEKAGTNQFIFSSSAAVYGSPEYLPIDEKHPVRPENYYGYTKLAIEQNLKWYETLKGF
KFAALRYFNAAGYDPKGRVRGLERTPANLLPIIMEAAVGIRKDFEVFGTDYETPDGSCVRDYIHVTDLAKAHVLSLDYLD
SEKKSLTVNLGSEKGYSVLEMVRLAEEVVGRSIPHKISGRRAGDPAKLLASSAMAQRLLQWVPEYSEAKTLLKTMWDVYQ
NPA
>Mature_323_residues
MRLLITGGAGYIGSHVVALLLEKKHELVIVDNLEKGNRSNLFSETQLIQGNIQDESVLENAFSKPIDAVFHFAAWKAAGE
SMTDPSKYALNNINGTLKLLTFMEKAGTNQFIFSSSAAVYGSPEYLPIDEKHPVRPENYYGYTKLAIEQNLKWYETLKGF
KFAALRYFNAAGYDPKGRVRGLERTPANLLPIIMEAAVGIRKDFEVFGTDYETPDGSCVRDYIHVTDLAKAHVLSLDYLD
SEKKSLTVNLGSEKGYSVLEMVRLAEEVVGRSIPHKISGRRAGDPAKLLASSAMAQRLLQWVPEYSEAKTLLKTMWDVYQ
NPA

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=39.1176470588235, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=39.1176470588235, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=39.1176470588235, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI42516563, Length=312, Percent_Identity=27.8846153846154, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7657641, Length=281, Percent_Identity=28.1138790035587, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786974, Length=312, Percent_Identity=40.0641025641026, Blast_Score=220, Evalue=9e-59,
Organism=Escherichia coli, GI1788353, Length=351, Percent_Identity=25.3561253561254, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790049, Length=225, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982035, Length=351, Percent_Identity=36.7521367521368, Blast_Score=190, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71982038, Length=353, Percent_Identity=36.5439093484419, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17539532, Length=332, Percent_Identity=23.7951807228916, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319493, Length=340, Percent_Identity=41.1764705882353, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI19923002, Length=339, Percent_Identity=39.2330383480826, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21356223, Length=325, Percent_Identity=25.8461538461538, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36021; Mature: 36021

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLITGGAGYIGSHVVALLLEKKHELVIVDNLEKGNRSNLFSETQLIQGNIQDESVLEN
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
AFSKPIDAVFHFAAWKAAGESMTDPSKYALNNINGTLKLLTFMEKAGTNQFIFSSSAAVY
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCEEC
GSPEYLPIDEKHPVRPENYYGYTKLAIEQNLKWYETLKGFKFAALRYFNAAGYDPKGRVR
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCHHCC
GLERTPANLLPIIMEAAVGIRKDFEVFGTDYETPDGSCVRDYIHVTDLAKAHVLSLDYLD
CCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHCC
SEKKSLTVNLGSEKGYSVLEMVRLAEEVVGRSIPHKISGRRAGDPAKLLASSAMAQRLLQ
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WVPEYSEAKTLLKTMWDVYQNPA
HCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLLITGGAGYIGSHVVALLLEKKHELVIVDNLEKGNRSNLFSETQLIQGNIQDESVLEN
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
AFSKPIDAVFHFAAWKAAGESMTDPSKYALNNINGTLKLLTFMEKAGTNQFIFSSSAAVY
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCEEC
GSPEYLPIDEKHPVRPENYYGYTKLAIEQNLKWYETLKGFKFAALRYFNAAGYDPKGRVR
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCHHCC
GLERTPANLLPIIMEAAVGIRKDFEVFGTDYETPDGSCVRDYIHVTDLAKAHVLSLDYLD
CCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHCC
SEKKSLTVNLGSEKGYSVLEMVRLAEEVVGRSIPHKISGRRAGDPAKLLASSAMAQRLLQ
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WVPEYSEAKTLLKTMWDVYQNPA
HCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]