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The map label for this gene is degU [H]

Identifier: 45658914

GI number: 45658914

Start: 3774974

End: 3775645

Strand: Direct

Name: degU [H]

Synonym: LIC13088

Alternate gene names: 45658914

Gene position: 3774974-3775645 (Clockwise)

Preceding gene: 45658913

Following gene: 45658915

Centisome position: 88.26

GC content: 37.8

Gene sequence:

>672_bases
ATGAAACCTACCGATACAAAAATATTTCTAGTCGATGATCACGCAATTCTTAGAGAAGGATTAAAAATGATTCTCTCCGG
CCAACCCGGTTTCGAAATTTGTGGCGAATCGGGAGACGCTGAAAAAGCATTAGATCAAATCGGCAAATTGAATCCAGATC
TAGTCATCACAGACATTTCAATGCCGGGATTAAGCGGAATCGATCTCGTAAAAAATCTGAGAAAATATTATCCAAATATC
CGAACTATCATTCTTTCACGTCATGATAATAAAGAATACGTTCAAAAATTATTAGAACTAGGGATAAACGGATACGTATT
AAAAGACGACGCAGGAAATGATCTTCTTCGTGCTATCGAAGCGGTTCATAAAGGAGAAACATATTTAAGTCCGGGGATAA
CGACACACTTTTTATCCGGATTTGTAGGTTCCGGGAAACCAGGAGAAGACAATCAAGACGCTAAAAAAGCGTTTTCGGTA
CTTTCAGATAGAGAAAGAGAAATTTTGAAATTAGTCGCCGAAGGAAACTCTAACGAATCCATTGGAAAAATATTAAGAAT
TTCTCCGGCTACGGTTAAGGTTCATCGCGCCAATATTATGAAAAAACTGGATCTACATAAGGTTGCAGATTTAGTAATGT
ATGCGATTCGCGCCGGTTTAATTGAATCCTAA

Upstream 100 bases:

>100_bases
TAAATGGTAAAATTAAGATTGATTCTTCTGCTGGGAAAGGAACTAAGTTTATCATCCGAATTCCTTTGGAAAAAAACAAA
AACACTTACGCTAAAAAAAC

Downstream 100 bases:

>100_bases
CTATTTATTTTGCGAAGTTTTGTTTTTTCAGATCAACATTTCAAAACCAAACTCTTTATAGATTTTTACTGATCCTGAAT
AGAAATTTAAAACCTAGGAA

Product: response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKPTDTKIFLVDDHAILREGLKMILSGQPGFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKYYPNI
RTIILSRHDNKEYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITTHFLSGFVGSGKPGEDNQDAKKAFSV
LSDREREILKLVAEGNSNESIGKILRISPATVKVHRANIMKKLDLHKVADLVMYAIRAGLIES

Sequences:

>Translated_223_residues
MKPTDTKIFLVDDHAILREGLKMILSGQPGFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKYYPNI
RTIILSRHDNKEYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITTHFLSGFVGSGKPGEDNQDAKKAFSV
LSDREREILKLVAEGNSNESIGKILRISPATVKVHRANIMKKLDLHKVADLVMYAIRAGLIES
>Mature_223_residues
MKPTDTKIFLVDDHAILREGLKMILSGQPGFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKYYPNI
RTIILSRHDNKEYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITTHFLSGFVGSGKPGEDNQDAKKAFSV
LSDREREILKLVAEGNSNESIGKILRISPATVKVHRANIMKKLDLHKVADLVMYAIRAGLIES

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=219, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=34.1836734693878, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1786747, Length=215, Percent_Identity=29.3023255813954, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787473, Length=188, Percent_Identity=34.5744680851064, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=28.8461538461538, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788546, Length=213, Percent_Identity=29.5774647887324, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1789937, Length=200, Percent_Identity=27, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24520; Mature: 24520

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTDTKIFLVDDHAILREGLKMILSGQPGFEICGESGDAEKALDQIGKLNPDLVITDIS
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEECC
MPGLSGIDLVKNLRKYYPNIRTIILSRHDNKEYVQKLLELGINGYVLKDDAGNDLLRAIE
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
AVHKGETYLSPGITTHFLSGFVGSGKPGEDNQDAKKAFSVLSDREREILKLVAEGNSNES
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGKILRISPATVKVHRANIMKKLDLHKVADLVMYAIRAGLIES
HHHEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPTDTKIFLVDDHAILREGLKMILSGQPGFEICGESGDAEKALDQIGKLNPDLVITDIS
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEECC
MPGLSGIDLVKNLRKYYPNIRTIILSRHDNKEYVQKLLELGINGYVLKDDAGNDLLRAIE
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
AVHKGETYLSPGITTHFLSGFVGSGKPGEDNQDAKKAFSVLSDREREILKLVAEGNSNES
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGKILRISPATVKVHRANIMKKLDLHKVADLVMYAIRAGLIES
HHHEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]