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The map label for this gene is dinP

Identifier: 45658878

GI number: 45658878

Start: 3724436

End: 3725530

Strand: Direct

Name: dinP

Synonym: LIC13052

Alternate gene names: 45658878

Gene position: 3724436-3725530 (Clockwise)

Preceding gene: 45658877

Following gene: 45658880

Centisome position: 87.08

GC content: 36.07

Gene sequence:

>1095_bases
TTGATTATGGAAACGCGCAAAATCATTCATGTGGATATGGATGCATTTTATGCCTCCGTAGAACAAAGAGATTTTCCAGA
ATACAAAGGCAAACCTCTAATTGTAGGTGGACCTCCTAATAGTAGATCGGTTGTTTCGGCTGCTTCCTACGAAGCTCGTA
AATTTGGAGTTCGTTCCGCGATGCCTTGTTCCAAAGCGGCACAACTTGCCCCTCAGGCGATTTTTGTTTTTCCCCGATTT
GAAGTATATAAAGAAGTTTCCAAACAGATTCGAGAAATTTTTTTAGAATATACGGATCTTGTCGAAATGCTTTCCTTAGA
CGAAGGTTATTTAGACGTTACATTCAATAAAAAGAATATTCCATTTGCAGTAACTATTGCAAAAGAAATCCGTACAGAAA
TTTTTAAACGCACTGAACTTACAGCTTCCGCTGGTGTAGGTAATTCTAAATTTATTTCTAAACTCGCATCTGAGAAAAAT
AAACCAAATGGACTTACAGTCGTTCTTCCCGATGACGTAATTTCTTTTATTGATCCGTTACCAGTAAGTAGCTTTCACGG
TGTGGGAAAAGTTACAGCACGGAAGATGAAAGAATTAGGAATTTATACCGGAAAAGATCTAAGAACAAAAAGTATAGATG
AACTTGTTCAACATTTTGGCAAAATGGGAATTTACTATTATAAAATTTCCAGAGGCGAGGATGAACGAATGGTCCAATCT
TCTCGAGAAAGAAAATCTCTCGGAGCAGAAAGCACTTTTGATCGAGACAAATTAGATTATGATGATTTGCTAAAACAACT
GAAAGACGTCGCCGTAGTAGTAGAAAGAAGATTAGAAAAAAAAGATTTTGCCGGAAAAACACTGACCCTCAAAATTAAAT
TTTACGATTTTAGTCTAAAGACCAGATCTAAAACCTTATCAGAACCTATCTTCAAAGCGGACGAACTTTATTCCACTGCA
ATAGAACTTTTTGAGGAATTTTTCGAAATTAAATACGGAAAAAAATCGGCGATCAAAGCAATTCGACTTCTTGGAATCAG
CCTTTCTCATCCAAATTCTGAGAACGAAGACCCCAACTTATTTTTAAATTTATAA

Upstream 100 bases:

>100_bases
CGATTCTGTTCGAATTTTAACCTTGATCCGAACAGAAGGAATAGAATTCGAAATTGAAAAAGACATTACAAATGTTTAGC
TATTTATAACCTGACTAAAA

Downstream 100 bases:

>100_bases
TATTCAAAAAAGAAAAATCTTCAGTTCTTATAGAAACTAATGCAAGTTCTGGGTAAAAAAATGAGAAAGAATTTCTAAAA
GTAAAAGTGGGCTCATACAT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MIMETRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSAMPCSKAAQLAPQAIFVFPRF
EVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNIPFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKN
KPNGLTVVLPDDVISFIDPLPVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQS
SRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLKTRSKTLSEPIFKADELYSTA
IELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNLFLNL

Sequences:

>Translated_364_residues
MIMETRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSAMPCSKAAQLAPQAIFVFPRF
EVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNIPFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKN
KPNGLTVVLPDDVISFIDPLPVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQS
SRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLKTRSKTLSEPIFKADELYSTA
IELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNLFLNL
>Mature_364_residues
MIMETRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSAMPCSKAAQLAPQAIFVFPRF
EVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNIPFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKN
KPNGLTVVLPDDVISFIDPLPVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQS
SRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLKTRSKTLSEPIFKADELYSTA
IELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNLFLNL

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=347, Percent_Identity=31.1239193083574, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7706681, Length=348, Percent_Identity=31.0344827586207, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI154350220, Length=288, Percent_Identity=31.25, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI7705344, Length=239, Percent_Identity=34.3096234309623, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786425, Length=355, Percent_Identity=41.1267605633803, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1787432, Length=217, Percent_Identity=29.9539170506912, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193205700, Length=411, Percent_Identity=27.007299270073, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17537959, Length=343, Percent_Identity=27.4052478134111, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193205702, Length=233, Percent_Identity=30.0429184549356, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324921, Length=328, Percent_Identity=26.5243902439024, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19923006, Length=341, Percent_Identity=25.5131964809384, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21355641, Length=283, Percent_Identity=26.5017667844523, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644984, Length=283, Percent_Identity=26.5017667844523, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24668444, Length=431, Percent_Identity=23.2018561484919, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 41375; Mature: 41375

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMETRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSA
CCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
MPCSKAAQLAPQAIFVFPRFEVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNI
CCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKNKPNGLTVVLPDDVISFIDPL
CEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHCCC
PVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQS
CCCHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
SRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLK
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEH
TRSKTLSEPIFKADELYSTAIELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCCCCCCCE
FLNL
EEEC
>Mature Secondary Structure
MIMETRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSA
CCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
MPCSKAAQLAPQAIFVFPRFEVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNI
CCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKNKPNGLTVVLPDDVISFIDPL
CEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHCCC
PVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQS
CCCHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
SRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLK
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEH
TRSKTLSEPIFKADELYSTAIELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCCCCCCCE
FLNL
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA