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The map label for this gene is uvrB

Identifier: 45658769

GI number: 45658769

Start: 3570065

End: 3572065

Strand: Reverse

Name: uvrB

Synonym: LIC12941

Alternate gene names: 45658769

Gene position: 3572065-3570065 (Counterclockwise)

Preceding gene: 45658770

Following gene: 45658768

Centisome position: 83.51

GC content: 39.23

Gene sequence:

>2001_bases
ATGGCTTCCGTTTTTAAAATTCATTCTGCATACCAGCCGGCCGGGGATCAAGTCAAAGCGATCCAAAATATTGCCGATTC
TTTTCAAAAAGGAGAGAAAAAGGTGACACTGGTAGGTGTGACCGGTTCGGGTAAAACCTTTACGATGGCTCAGGTCATTC
AAAATTTGGGGCTTCCTACTCTGGTCTTATCGCATAACAAAACTTTGGCGGCTCAACTCTTTCGAGAGTTTAAGGAGTTT
TTTCCCGAAAATGCAGTGGAATATTTTGTTTCCTATTATGATTATTATCAACCGGAGGCTTATGTTCCTTCTTCGGATAC
TTTTATCGAGAAGGACAGTTCTATCAACGAAGAGATCGATAAACTTAGATTGAGAGCCACTTCTTCTTTGTTGGAGAGGG
AAGACGTAGTCATTGTAAGTTCTGTTTCTTGTATTTACGGTTTGGGTTCTCCGGAAGAATATACAAACTCAGTTGTAGCG
TTAAAAGTAGGTGATACGATCGAAAGGGACACGGTAATTCGTAAGTTGTTACACATACAATATAACCGAAACGATTTGGA
TTTTTCGAGAGGAAACTTTCGGGTTAGAGGAGATTCGATCGAAATCTATCCTGCGTATCATACCGACGGAATCAGAATTG
AATTTTTTGGGGACGAAATCGATTCGATCAGTAGAATCAATCCAGTTACCGCACAAACAATTTTTAAATTAGAAAAAGCT
TATATTTATCCAGCAAAACACTTTATTACTTCCGGTCCGAAGGTTAAAGAAGCGGTCGAAAATATAAGAGCAGAAGTAGA
TGCTCAGACTGATTTTTTTAGAAAGAATAATAAACTTCTGGAAGCAGAAAGGATCTTATCCCGTACGAATTACGATATGG
AAATGCTCCAGGAAATGGGATATTGCAACGGAATAGAAAATTATTCCAGACATCTTACTGGAAGAAAACCGGGAGAACGC
CCAGCTTGTTTGATCGATTATTTTCAAGGAGAGTTTCTTCTGATTGTGGACGAATCGCACGTAACGATTCCGCAGATCGG
AGGAATGTTTGCTGGAGATAGAGCCCGTAAGCAGACATTAGTCGACTTTGGTTTTAGACTTCCGAGTGCTTTGGATAACA
GACCTCTTAACTTTCAAGAGTTCGAAACTTTAACGCCTAGAACCCTTTATGTTTCTGCAACTCCCGCTGAGTATGAAATT
GAAAAGAGTTCTAAGGTTGTGGAGCAGATCATTCGACCAACCGGACTTTTGGATCCGATCGTGGACGTACGTCCCACTAA
AAATCAAATCGAAGACCTTTTGGTGGAAATCCGTAAACGGATAGACGCCGGAGAAAGAGTTCTTGTTACTACTCTCACAA
AAAAAATGTCAGAAGATCTTACCGATTATTACGAAGAGATTGGTTTAAAAGTGGCTTATCTACATTCTGAGGTAGAAACT
TTGGATCGTGTCGGGATCATTCGAGATTTAAGAAAGGGAATTTACGACGTTCTGATTGGAATCAATCTGTTACGCGAAGG
TTTAGATATTCCAGAAGTTTCTTTGGTTGCTATTTTGGACGCGGATAAGGAAGGCTTTTTAAGAAATTATAAATCTCTAA
TACAGACGATTGGTCGTGCCGCTAGAAATGTAAATGGAACGGCGATTCTTTACGCAGATAAAACCACCGATTCTATGGCA
AAAGCAATCGAAGAAACCAAACGTCGTAGAAAAATCCAGGAAGATCATAATCTCAAATTTGGTATCACTCCTCTGACTAT
CAAAAAAGAAGTAGGAGATATTATCGAAAGAGAAGAGAAGGAGCGAACTTCGGAAGATCTGGTTCTGGAAGATGTGGAGA
AAAAATTTAATTCTAAGAAATTTCCGAACAAGGAAGTATTGAAAGAAAAACTTCGTGAAGAGATGATGAAAGCGGCTAAG
GAACTTGATTTTGAAAGAGCTGCAATTTTGAGGGATAAAATGTTATCGATTCAAACGGAAGATTCTTCAGCCAAAAATTA
A

Upstream 100 bases:

>100_bases
GATGGTCATGCAAAAACTTTTTGATGAACTTGATCTTGAAATTTTAGAAAATAAGAAACAAGCTCAGTTCAACGCCAAAA
AAAAATTGTCATAGTGTAGT

Downstream 100 bases:

>100_bases
AAATAAGGAATGTATTGTTGATCACTTTATTGATTTGTTTATTGACCTTTGGTATGAGCGTTTGGTGTTTTGCTTCCGAA
GAGAAACTATATAAGTTTAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MASVFKIHSAYQPAGDQVKAIQNIADSFQKGEKKVTLVGVTGSGKTFTMAQVIQNLGLPTLVLSHNKTLAAQLFREFKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEEIDKLRLRATSSLLEREDVVIVSSVSCIYGLGSPEEYTNSVVA
LKVGDTIERDTVIRKLLHIQYNRNDLDFSRGNFRVRGDSIEIYPAYHTDGIRIEFFGDEIDSISRINPVTAQTIFKLEKA
YIYPAKHFITSGPKVKEAVENIRAEVDAQTDFFRKNNKLLEAERILSRTNYDMEMLQEMGYCNGIENYSRHLTGRKPGER
PACLIDYFQGEFLLIVDESHVTIPQIGGMFAGDRARKQTLVDFGFRLPSALDNRPLNFQEFETLTPRTLYVSATPAEYEI
EKSSKVVEQIIRPTGLLDPIVDVRPTKNQIEDLLVEIRKRIDAGERVLVTTLTKKMSEDLTDYYEEIGLKVAYLHSEVET
LDRVGIIRDLRKGIYDVLIGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLIQTIGRAARNVNGTAILYADKTTDSMA
KAIEETKRRRKIQEDHNLKFGITPLTIKKEVGDIIEREEKERTSEDLVLEDVEKKFNSKKFPNKEVLKEKLREEMMKAAK
ELDFERAAILRDKMLSIQTEDSSAKN

Sequences:

>Translated_666_residues
MASVFKIHSAYQPAGDQVKAIQNIADSFQKGEKKVTLVGVTGSGKTFTMAQVIQNLGLPTLVLSHNKTLAAQLFREFKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEEIDKLRLRATSSLLEREDVVIVSSVSCIYGLGSPEEYTNSVVA
LKVGDTIERDTVIRKLLHIQYNRNDLDFSRGNFRVRGDSIEIYPAYHTDGIRIEFFGDEIDSISRINPVTAQTIFKLEKA
YIYPAKHFITSGPKVKEAVENIRAEVDAQTDFFRKNNKLLEAERILSRTNYDMEMLQEMGYCNGIENYSRHLTGRKPGER
PACLIDYFQGEFLLIVDESHVTIPQIGGMFAGDRARKQTLVDFGFRLPSALDNRPLNFQEFETLTPRTLYVSATPAEYEI
EKSSKVVEQIIRPTGLLDPIVDVRPTKNQIEDLLVEIRKRIDAGERVLVTTLTKKMSEDLTDYYEEIGLKVAYLHSEVET
LDRVGIIRDLRKGIYDVLIGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLIQTIGRAARNVNGTAILYADKTTDSMA
KAIEETKRRRKIQEDHNLKFGITPLTIKKEVGDIIEREEKERTSEDLVLEDVEKKFNSKKFPNKEVLKEKLREEMMKAAK
ELDFERAAILRDKMLSIQTEDSSAKN
>Mature_665_residues
ASVFKIHSAYQPAGDQVKAIQNIADSFQKGEKKVTLVGVTGSGKTFTMAQVIQNLGLPTLVLSHNKTLAAQLFREFKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEEIDKLRLRATSSLLEREDVVIVSSVSCIYGLGSPEEYTNSVVAL
KVGDTIERDTVIRKLLHIQYNRNDLDFSRGNFRVRGDSIEIYPAYHTDGIRIEFFGDEIDSISRINPVTAQTIFKLEKAY
IYPAKHFITSGPKVKEAVENIRAEVDAQTDFFRKNNKLLEAERILSRTNYDMEMLQEMGYCNGIENYSRHLTGRKPGERP
ACLIDYFQGEFLLIVDESHVTIPQIGGMFAGDRARKQTLVDFGFRLPSALDNRPLNFQEFETLTPRTLYVSATPAEYEIE
KSSKVVEQIIRPTGLLDPIVDVRPTKNQIEDLLVEIRKRIDAGERVLVTTLTKKMSEDLTDYYEEIGLKVAYLHSEVETL
DRVGIIRDLRKGIYDVLIGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLIQTIGRAARNVNGTAILYADKTTDSMAK
AIEETKRRRKIQEDHNLKFGITPLTIKKEVGDIIEREEKERTSEDLVLEDVEKKFNSKKFPNKEVLKEKLREEMMKAAKE
LDFERAAILRDKMLSIQTEDSSAKN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=56.9924812030075, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75956; Mature: 75824

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVFKIHSAYQPAGDQVKAIQNIADSFQKGEKKVTLVGVTGSGKTFTMAQVIQNLGLPT
CCCCEEHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEHHHHHHHHCCCCE
LVLSHNKTLAAQLFREFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEEID
EEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHH
KLRLRATSSLLEREDVVIVSSVSCIYGLGSPEEYTNSVVALKVGDTIERDTVIRKLLHIQ
HHHHHHHHHHHCCCCEEEEEECHHHHCCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHH
YNRNDLDFSRGNFRVRGDSIEIYPAYHTDGIRIEFFGDEIDSISRINPVTAQTIFKLEKA
CCCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHH
YIYPAKHFITSGPKVKEAVENIRAEVDAQTDFFRKNNKLLEAERILSRTNYDMEMLQEMG
HCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
YCNGIENYSRHLTGRKPGERPACLIDYFQGEFLLIVDESHVTIPQIGGMFAGDRARKQTL
CCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHH
VDFGFRLPSALDNRPLNFQEFETLTPRTLYVSATPAEYEIEKSSKVVEQIIRPTGLLDPI
HHHHCCCCHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
VDVRPTKNQIEDLLVEIRKRIDAGERVLVTTLTKKMSEDLTDYYEEIGLKVAYLHSEVET
CCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
LDRVGIIRDLRKGIYDVLIGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLIQTIGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGTAILYADKTTDSMAKAIEETKRRRKIQEDHNLKFGITPLTIKKEVGDIIEREEK
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHHHHH
ERTSEDLVLEDVEKKFNSKKFPNKEVLKEKLREEMMKAAKELDFERAAILRDKMLSIQTE
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEC
DSSAKN
CCCCCC
>Mature Secondary Structure 
ASVFKIHSAYQPAGDQVKAIQNIADSFQKGEKKVTLVGVTGSGKTFTMAQVIQNLGLPT
CCCEEHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEHHHHHHHHCCCCE
LVLSHNKTLAAQLFREFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEEID
EEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHH
KLRLRATSSLLEREDVVIVSSVSCIYGLGSPEEYTNSVVALKVGDTIERDTVIRKLLHIQ
HHHHHHHHHHHCCCCEEEEEECHHHHCCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHH
YNRNDLDFSRGNFRVRGDSIEIYPAYHTDGIRIEFFGDEIDSISRINPVTAQTIFKLEKA
CCCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHH
YIYPAKHFITSGPKVKEAVENIRAEVDAQTDFFRKNNKLLEAERILSRTNYDMEMLQEMG
HCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
YCNGIENYSRHLTGRKPGERPACLIDYFQGEFLLIVDESHVTIPQIGGMFAGDRARKQTL
CCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHH
VDFGFRLPSALDNRPLNFQEFETLTPRTLYVSATPAEYEIEKSSKVVEQIIRPTGLLDPI
HHHHCCCCHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
VDVRPTKNQIEDLLVEIRKRIDAGERVLVTTLTKKMSEDLTDYYEEIGLKVAYLHSEVET
CCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
LDRVGIIRDLRKGIYDVLIGINLLREGLDIPEVSLVAILDADKEGFLRNYKSLIQTIGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGTAILYADKTTDSMAKAIEETKRRRKIQEDHNLKFGITPLTIKKEVGDIIEREEK
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHHHHH
ERTSEDLVLEDVEKKFNSKKFPNKEVLKEKLREEMMKAAKELDFERAAILRDKMLSIQTE
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEC
DSSAKN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA