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The map label for this gene is yqeF [C]

Identifier: 45658626

GI number: 45658626

Start: 3402298

End: 3403623

Strand: Reverse

Name: yqeF [C]

Synonym: LIC12795

Alternate gene names: 45658626

Gene position: 3403623-3402298 (Counterclockwise)

Preceding gene: 45658627

Following gene: 45658625

Centisome position: 79.58

GC content: 42.68

Gene sequence:

>1326_bases
ATGAAATTAACAAAACCTTTGGCAATTTGTACACCAAGAAGAACTCCTTTTGCTCAGATCGCGAAAGCTCTCGGACCTTA
TCCTGGACATCACCTGGGAAAAATAGTCGCAGAAGATATTCTTGCTAAAAGCAAACTTAAGCCGTCTCAAATCGATGGAG
TTGTAGTAGGAGAAGGATTTAGCAATGCTCCTAATTCTGCGAGAGTGATTGCAAACCTGGTCGGAATGAGGGATGAAATC
GCTTGTATCACCGTTGCGAACAATTGTGTTTCCGGTATGGAAGCGGTTGCGGAAGCGGCTCGTAGAATCGTGTTAGGTGA
AGGAGAAGTTTTTCTTGCGATCGGAGAAGAATCTCAAACTTCTATGCCTTTTGTTGTTAAAAATGCTCGCTTGAACAAAA
AAGCGGGATCTTTGGATAAGTTGAAGAAACTTCTTCCGGATAATCTTCCCGAGGGAGTTGAACTCAGAGATACATTGGAA
GACGGACTTGGTGACGGAGAAACTTCTTACGGTATGCAGGTAACCGCAGAAATTGTTGCTCAGAATTATGGTCTTTCTCG
TGAGATCCAAGATAAACTTGCGTTTGAGTCTTTCAAAAGAGCATTAGAAGCTTCTAAAGCAGGTAAATACTCTCCATATA
TCATTCCTATGAAAGACGACGAAGGGAACGAACTTACGATCGACGAGGCTGTTGGCCTTCGTGAAGGTCTGGTAGAAAAC
CCGACTCGTATGGGAAGAGCGATGCTTATGTTCGATAACCCTGGTATGAAGTTTGAAGAATTTAAAACGAAATATTCCAA
GGATCTTAAAAAGTCTCATGGCCCTACGGTTTCTATCTTCAATGCTAGTCCTCGTTCCGACGGAGCTGCAGGTGTTATCG
TTACTACTGTTGAAAAAGCAAAAGAACTCGGACTTACGATCGAAGCGGTGGTTTCCGGCTGGCACATGAAAGGGGTTCAT
CCAAATAACATGGGTATCGGACAGGCTGTTGCCACCAAGGCTTTGTTAGACGAAACTGGAATTAAAATTCAAGACGTTGA
CTATGTTGAAATTCATGAGGCTTTTGCCGCAACTGCGGTAGGTGCACTTGAACAAATCAAAATGGATACCGGTTGGGATT
GGGAAAAATCTTTTGATGCTAAGAAGATCAATCCGAATGGTGGTTCTATCGCAATTGGTCATCCGTTTGGAGCAACTGGA
ATTCGTTTGATTGCAAATGCGATTATGGATTTAAAAGAAGATTCTTCCGCAAATAAGGTACTGATTACTGCTTGTGCTCA
CGGTGGAATTGCTGGTTCCATGTTGATTGAAAGATACAAGGGTTAA

Upstream 100 bases:

>100_bases
TCCTGATGAGTTTCAACAACTGGTAGGGGACTATGTGGAGAATTTTGAATATTCTAAAAAATGAATTTATGATTAAGAAT
TTTAAGTTTGGAGAAAAAAA

Downstream 100 bases:

>100_bases
TTCGTTTTTTAGAATATTCTAATAAGTGAATCCCTCCTCGCCTCTGAATTTTATGAAACAAGGCGGCGAGGAGTACAACG
AAAATGTATGATCACATGTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVH
PNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG

Sequences:

>Translated_441_residues
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVH
PNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG
>Mature_441_residues
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVH
PNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=443, Percent_Identity=28.2167042889391, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI148539872, Length=437, Percent_Identity=29.0617848970252, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501853, Length=408, Percent_Identity=29.4117647058824, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4557237, Length=439, Percent_Identity=27.5626423690205, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4504327, Length=454, Percent_Identity=25.7709251101322, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI87082165, Length=443, Percent_Identity=29.7968397291196, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787663, Length=436, Percent_Identity=29.5871559633028, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788683, Length=434, Percent_Identity=30.184331797235, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788554, Length=437, Percent_Identity=28.3752860411899, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=27.8350515463918, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17551802, Length=449, Percent_Identity=30.0668151447661, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=440, Percent_Identity=29.0909090909091, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=428, Percent_Identity=26.1682242990654, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17535921, Length=440, Percent_Identity=24.7727272727273, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325229, Length=449, Percent_Identity=28.7305122494432, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=332, Percent_Identity=29.8192771084337, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24655093, Length=435, Percent_Identity=28.2758620689655, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24640423, Length=438, Percent_Identity=27.8538812785388, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17648125, Length=439, Percent_Identity=28.9293849658314, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137578, Length=451, Percent_Identity=30.1552106430155, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 47281; Mature: 47281

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGF
CCCCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
SNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQT
CCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCC
SMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVA
CCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
QNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVEN
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHCHHHHHHCC
PTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKA
HHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEHHHH
KELGLTIEAVVSGWHMKGVHPNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAV
HHHCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
GALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKV
HHHHHHCCCCCCCHHHCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
LITACAHGGIAGSMLIERYKG
EEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGF
CCCCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
SNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQT
CCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCC
SMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVA
CCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
QNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVEN
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHCHHHHHHCC
PTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKA
HHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEHHHH
KELGLTIEAVVSGWHMKGVHPNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAV
HHHCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
GALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKV
HHHHHHCCCCCCCHHHCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
LITACAHGGIAGSMLIERYKG
EEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA