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The map label for this gene is tpx

Identifier: 45658599

GI number: 45658599

Start: 3371458

End: 3371973

Strand: Direct

Name: tpx

Synonym: LIC12765

Alternate gene names: 45658599

Gene position: 3371458-3371973 (Clockwise)

Preceding gene: 45658596

Following gene: 45658619

Centisome position: 78.82

GC content: 42.05

Gene sequence:

>516_bases
ATGACAAAAGTTACTCTGAAAGGCAATCCAGTACAACTCGAAGGAAAAATTCCATCTCCAGGAGACAAGGCTCCCGATTT
CAAAGCGATCAAACAAGATCTTTCCGAATTTAGTCTTAAAGATTATGCGGGCAAAGTAAAAATACTCGTAGCAGTTCCAA
GTTTAGATACTTCCGTCTGTGCCCTCGAAACCAAAGCATTTAACGAAAAAGCAGCAGGAATTTCCGGCGTAACAACCCTA
GTTATTTCTGGAGACCTACCTTTTGCAATGGGTCGTTTTTGTTCTACAGAAGGAATCAATTCTCCGAACCTAGTAACCGG
ATCCCAATACAGAGATTTTTCATTTTCAAAAGCTTACGGAACTCATATCGCAGACGGACCACTCAAAGGACTTTCTGCAA
GAGCAGTCTTTGTATTAGATAAATCGGATACGGTTCGTTATGTGGAAATTGTACCTGAAATCACGACGGAACCGAACTAC
ACAGCAGCAATCGCGGCTGCAAACGCAGCACTTTAA

Upstream 100 bases:

>100_bases
CGAAAAATTTAGAAAAAATCCTGCTTTCTCGGACATCGTCCTTAGATACAATGACGCTTTCGTATATTCTTTAATTCTAA
TTATAGGAAGGAAAATTCAA

Downstream 100 bases:

>100_bases
AAAAACCGAATATTCTTGGTTTGTTTTACTTATAGATCAAGCCAAGAATAATTCAAAAAAATACATTAGAATTGTTGAAA
AATTAATTCTCTATCGGTTT

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTKVTLKGNPVQLEGKIPSPGDKAPDFKAIKQDLSEFSLKDYAGKVKILVAVPSLDTSVCALETKAFNEKAAGISGVTTL
VISGDLPFAMGRFCSTEGINSPNLVTGSQYRDFSFSKAYGTHIADGPLKGLSARAVFVLDKSDTVRYVEIVPEITTEPNY
TAAIAAANAAL

Sequences:

>Translated_171_residues
MTKVTLKGNPVQLEGKIPSPGDKAPDFKAIKQDLSEFSLKDYAGKVKILVAVPSLDTSVCALETKAFNEKAAGISGVTTL
VISGDLPFAMGRFCSTEGINSPNLVTGSQYRDFSFSKAYGTHIADGPLKGLSARAVFVLDKSDTVRYVEIVPEITTEPNY
TAAIAAANAAL
>Mature_170_residues
TKVTLKGNPVQLEGKIPSPGDKAPDFKAIKQDLSEFSLKDYAGKVKILVAVPSLDTSVCALETKAFNEKAAGISGVTTLV
ISGDLPFAMGRFCSTEGINSPNLVTGSQYRDFSFSKAYGTHIADGPLKGLSARAVFVLDKSDTVRYVEIVPEITTEPNYT
AAIAAANAAL

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=166, Percent_Identity=49.3975903614458, Blast_Score=165, Evalue=1e-42,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_LEPIC (Q72NR4)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002685.1
- ProteinModelPortal:   Q72NR4
- SMR:   Q72NR4
- GeneID:   2770792
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12765
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- ProtClustDB:   PRK00522
- BioCyc:   LINT267671:LIC_12765-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18061; Mature: 17930

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVTLKGNPVQLEGKIPSPGDKAPDFKAIKQDLSEFSLKDYAGKVKILVAVPSLDTSVC
CEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEE
ALETKAFNEKAAGISGVTTLVISGDLPFAMGRFCSTEGINSPNLVTGSQYRDFSFSKAYG
EEEHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHCC
THIADGPLKGLSARAVFVLDKSDTVRYVEIVPEITTEPNYTAAIAAANAAL
CCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
TKVTLKGNPVQLEGKIPSPGDKAPDFKAIKQDLSEFSLKDYAGKVKILVAVPSLDTSVC
EEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEE
ALETKAFNEKAAGISGVTTLVISGDLPFAMGRFCSTEGINSPNLVTGSQYRDFSFSKAYG
EEEHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHCC
THIADGPLKGLSARAVFVLDKSDTVRYVEIVPEITTEPNYTAAIAAANAAL
CCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA