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The map label for this gene is nuoH

Identifier: 45658581

GI number: 45658581

Start: 3343053

End: 3344093

Strand: Direct

Name: nuoH

Synonym: LIC12747

Alternate gene names: 45658581

Gene position: 3343053-3344093 (Clockwise)

Preceding gene: 45658580

Following gene: 45658582

Centisome position: 78.16

GC content: 41.59

Gene sequence:

>1041_bases
ATGAACTGGAACGAAATTCTATTTTGGCTTTTAAAAAGCGGGCTTTTCTTTTTTATACTCATCACTGCATGCGCATACTA
TACTCTCGCAGAAAGAAAGGTCGCAGGTTTTATCCAAGATCGCAAAGGTCCGAACCGCGCCGGTTTTTGGGGCTTGTTAC
AACCTCTCGCGGATGGAATTAAATTTTTGACTAAAGAGGAAGTGTTTCCCGTTCAAGTAAATAAGGTAATGTATCTAATC
GCTCCAGCGATTTCCATGACTTGCGCGATTATGGCTTGGTCCGTAGTTCCACTGGGAGGACAAATTCCACTTCCTTCTTG
GCTTCAGGAAAAAACCGGTCTTACTTTTTTAGATCTACAAATCGCCAATCCGGATACGGGAATTTTATTTTTATTTGCGA
TTTCCTCTTTAGCGGTTTATGGAATTATCATAGCGGGTTGGGCGAGTAATAACAAATATTCGTTGTTAGGTGCGGTTCGT
TCTACGGCACAGATGATCAGCTATGAACTTCCTCTCGGAATGAGCGTGGTTTCGATCGTGATTTTATCTGGTTCTTTAAG
ACTTACCGACATCAGCGCGTCTCAGGTAGGTCTTTGGAACATTTTCAAACTTCCGGGGTTCATCGCGTTTTGTCTGTTTG
TAGTAGCCATGTTTGCAGAAACAAACCGCTTACCTTTTGATTTGGCGGAGGCGGAATCGGAACTGGTTGTGGGATTCCAC
ACAGAATACGGAGCCTTTAAGTTCGCACTCTTTTTTATCGCGGAATATATGAACATGATCACAATGAGTTGTGTAGTAAC
GCTTCTTTTTTTTGGAGGATATCAGGTTCCGTTCGGAATTTTAGAAGGGCACGTATTACAACCGTTATTCGGACTTGTCT
TCTTTTTAGGAAAGGTATTATTTTTCACCTTTTTGTTTTTATGGGTACGATGGACCCTCCCCCGTTTCCGTTATGATCAA
CTGATGTCTTTGGGATGGAAAAAACTCATTCCTTGGGCGATTTTGAACATACTAATCGCGAGTATCTATATACAATTTTA
A

Upstream 100 bases:

>100_bases
AGTTTGACGCAAAATTGAAAGTAAAACCGATCGTACCCGATCATCCTCGAAGAAGAAAAGAAGATAAGATCGAGTCGACT
GCAGGAGAAAAGACAAGTCC

Downstream 100 bases:

>100_bases
GAATATAAGAAATATGTCATTTACAGATCAACCTCAACTGCTTTTGTTTTTTCTATTCGCTTCGGTGATGATACTCAGTT
CGTTGGGAGTGATTTTTCAT

Product: NADH dehydrogenase subunit I H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGFWGLLQPLADGIKFLTKEEVFPVQVNKVMYLI
APAISMTCAIMAWSVVPLGGQIPLPSWLQEKTGLTFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAVR
STAQMISYELPLGMSVVSIVILSGSLRLTDISASQVGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQPLFGLVFFLGKVLFFTFLFLWVRWTLPRFRYDQ
LMSLGWKKLIPWAILNILIASIYIQF

Sequences:

>Translated_346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGFWGLLQPLADGIKFLTKEEVFPVQVNKVMYLI
APAISMTCAIMAWSVVPLGGQIPLPSWLQEKTGLTFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAVR
STAQMISYELPLGMSVVSIVILSGSLRLTDISASQVGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQPLFGLVFFLGKVLFFTFLFLWVRWTLPRFRYDQ
LMSLGWKKLIPWAILNILIASIYIQF
>Mature_346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGFWGLLQPLADGIKFLTKEEVFPVQVNKVMYLI
APAISMTCAIMAWSVVPLGGQIPLPSWLQEKTGLTFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAVR
STAQMISYELPLGMSVVSIVILSGSLRLTDISASQVGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQPLFGLVFFLGKVLFFTFLFLWVRWTLPRFRYDQ
LMSLGWKKLIPWAILNILIASIYIQF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=309, Percent_Identity=42.3948220064725, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1788618, Length=340, Percent_Identity=40.5882352941176, Blast_Score=255, Evalue=2e-69,
Organism=Escherichia coli, GI1789077, Length=302, Percent_Identity=27.4834437086093, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 38965; Mature: 38965

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGFWGLLQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KFLTKEEVFPVQVNKVMYLIAPAISMTCAIMAWSVVPLGGQIPLPSWLQEKTGLTFLDLQ
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEE
IANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAVRSTAQMISYELPLGMSVVSIV
ECCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ILSGSLRLTDISASQVGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQPLFGLVFFLGKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHH
FFTFLFLWVRWTLPRFRYDQLMSLGWKKLIPWAILNILIASIYIQF
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGFWGLLQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KFLTKEEVFPVQVNKVMYLIAPAISMTCAIMAWSVVPLGGQIPLPSWLQEKTGLTFLDLQ
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEE
IANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAVRSTAQMISYELPLGMSVVSIV
ECCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ILSGSLRLTDISASQVGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQPLFGLVFFLGKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHH
FFTFLFLWVRWTLPRFRYDQLMSLGWKKLIPWAILNILIASIYIQF
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA