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The map label for this gene is mtnC

Identifier: 45658553

GI number: 45658553

Start: 3308260

End: 3308964

Strand: Direct

Name: mtnC

Synonym: LIC12718

Alternate gene names: 45658553

Gene position: 3308260-3308964 (Clockwise)

Preceding gene: 45658552

Following gene: 45658554

Centisome position: 77.35

GC content: 33.62

Gene sequence:

>705_bases
TTGAATATAAAAACTTTCGAATTCTATTTATTCGATATTGAAGGAACTACAACTCCGATCGAATTCGTTCACAAAATTCT
TTTTCCTTACTCTGTGGAAAAGTTTGATTCTTTTTTTCAATCGAACTTACTTGAAAAAGAATGGATCGAAAAATTAATCT
TAGAAGGTAAAAACGATACTACCTATTCTGGAAAACTTTCGGATTCCGCTTTCGATCTGAGTGAATATTGTAAACATCTC
GTTTCGTTGGATCGCAAAAGTGGTATTTTGAAAGAGATTCAAGGTAGAATTTGGAAATCAGGTTATGAAAATGGAGAACT
AAAAAGTTCAATGTTTTCAGACGTTCCCTCTTTTTTAAAAAAAATCCAAGCTTCTAAAAAAAAGTCTGCGGTTTATTCTT
CTGGCAGTATTCAAGCGCAAAAGTTAATTTTTGAATATTCAGATTTTGGCAACTTAACCCATTTTTTTTACGCTTACTTC
GACACTGGAGTCGGAGGAAAAAGAGAATCTTCCAGTTACTCTAAAATTTCAGAACAATTAGGAGTTGCACCAGAGAAAAT
TCTATTTTTCACGGATATTAAAGAAGAAGCGGACGCCGCCAAAGAAGCAAAACTTCACTCCGCAATTTTAGAACGTCCCG
GTAATTATCCTCAACCGCAACACTCTCATTTTAAAATTTCTTCTTTTGAAGGTTTGAATCCTTAA

Upstream 100 bases:

>100_bases
CTTTATCTTGGTTGATTGTCTTGAAAAATTTTGAAAAGGACGAAAAAGACGTACATGAATATTTGGTTTTAGAAGCCGAA
AAAATCAAAGGGTAGCCTAA

Downstream 100 bases:

>100_bases
TAACAGAATGGATTTTTCCCACATTTTCAAGATTTGTCCGTAAAATCAAAGTTTGGTGGGAGTTCCCACATTTTCAAGAT
TTGTCCGTAAAATCAAAGTT

Product: putative enolase-phosphatase E-1

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDTTYSGKLSDSAFDLSEYCKHL
VSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLKKIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYF
DTGVGGKRESSSYSKISEQLGVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP

Sequences:

>Translated_234_residues
MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDTTYSGKLSDSAFDLSEYCKHL
VSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLKKIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYF
DTGVGGKRESSSYSKISEQLGVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP
>Mature_234_residues
MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDTTYSGKLSDSAFDLSEYCKHL
VSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLKKIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYF
DTGVGGKRESSSYSKISEQLGVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=222, Percent_Identity=38.7387387387387, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI115533232, Length=232, Percent_Identity=37.5, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320797, Length=242, Percent_Identity=33.8842975206612, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360080, Length=220, Percent_Identity=42.2727272727273, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24644163, Length=220, Percent_Identity=42.2727272727273, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_LEPIC (Q72NW0)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002639.1
- HSSP:   P32626
- ProteinModelPortal:   Q72NW0
- SMR:   Q72NW0
- GeneID:   2770784
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12718
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- BioCyc:   LINT267671:LIC_12718-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- TIGRFAMs:   TIGR01691

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 26678; Mature: 26678

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDT
CCCEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
TYSGKLSDSAFDLSEYCKHLVSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLK
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYFDTGVGGKRESSSYSKISEQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP
CCCHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MNIKTFEFYLFDIEGTTTPIEFVHKILFPYSVEKFDSFFQSNLLEKEWIEKLILEGKNDT
CCCEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
TYSGKLSDSAFDLSEYCKHLVSLDRKSGILKEIQGRIWKSGYENGELKSSMFSDVPSFLK
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KIQASKKKSAVYSSGSIQAQKLIFEYSDFGNLTHFFYAYFDTGVGGKRESSSYSKISEQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GVAPEKILFFTDIKEEADAAKEAKLHSAILERPGNYPQPQHSHFKISSFEGLNP
CCCHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA