Click here to switch to the map view.

The map label for this gene is cyaA

Identifier: 45658506

GI number: 45658506

Start: 3231623

End: 3233872

Strand: Reverse

Name: cyaA

Synonym: LIC12670

Alternate gene names: 45658506

Gene position: 3233872-3231623 (Counterclockwise)

Preceding gene: 45658509

Following gene: 45658505

Centisome position: 75.61

GC content: 37.24

Gene sequence:

>2250_bases
ATGACAGAAGATAAAACGTTCTTATTCTGCTCCAGACTTAAGGAAGGTGGGATGTTGGATCGATGGAAGGATAAAAATGA
CAAATCGGTTCGTTGGGAAGAGCTACCAAATCTTCATTCTGATTTGCAGGATTTGGATCTGATCATACGAAGTTTGATTT
CGGAAAAACTTTCTCTTGGAATTCGAGAAATCATTTTTTGTCTTTCTGCAGAACAAGCTCTATCTCTAAAAAAATCCAGG
GATTTTTTAAAACTTATAAAAGATCTTAAAAGAGCTGGTTTTACTATTTCATCTGCGGACAAGGATAAAATACTTTCCAC
AAACGTAGAATCTTCTTCTAAATTCTTTCGTTATTTAGAAAACCGTTCTAGAAATGTAAATTGTTTGGTTTGGACAGAGG
ATTTAGCACTTTCTCAGATCGAATCAAAATATTATGATTTTCTTAATCATTTCCACGGTTACAAATTTGAATCATTTCGT
CCGTCCAGGTTTACAATTCGTGTAAAACTACTTTCTATCGTTTCTGCGATTATCACTCTTAGTATGGGCCTGATGATTAC
TATGGCTACGTACTTTTTTAGGAAATACAGCGAAATTCTAATTCAAGAATATAATCTATCTCTTGCTAGAATGACAGGCA
TTCAATTGAGCGGACAATTGAAAGAAACCACTCGTAAAATTCAGGATTTTCGTTCTGAAGATTCTGAAAAATTTTTTAGA
ACCAATTCAAACGCGGTTGCATACGTACGTTTTAAAAACAAGACGGTAAATTCCGCTTTGGAAATAGATTCCCTTTTTTG
GAATTCAAAATTCTTAAAGTCTAATTCGGTTGTACCTGATCCTACAAATCTAAAAAATGCGTTGGAAAAATCTTTTTCCC
GTTTGTCAGGTACATTAGAAATATTGAATGTTTCTAATGAGTTTGGTTTCCCTGCGGTTGCAGTTTTGCTTCCGGTTGGA
GTCGAAATTTCAGGTTTGGTTTTTTCCGCTTCCGAATTTTTAGGTTCTTTTCTTAGTGTTAGACAAACCGATTTTTTTCA
AATGATCGTGGTGGATTCTTCTGGAAACTTGATCGCTCATTCTAACGATAAAGAGGCGGTTTCCGGAAAGGATTATAAAA
AACATCCTCTTGTGGAAAATATGTTACGTAGTCCTTCGGACAATGGTTCTCAACGATTCGATTTCGAAGGTAGAGAAGTA
TTAGGTTCTTATCAACAATTGGAAGTGGGTGGTCTTGGAATTATTTCTACGTTAGACGCTGATATTGCCTTTGAAGCGGT
GTATAAGATCAGAAGACAAAATTTTTGGATTATGATTTCTGTTTTGTCAGTTGCGTTTTTTGTAGTGTTCGTTTTTTCAA
GAACCCTTACGATTCCGATCATTCAACTTCTTTCTGCAACTAAAAAAGTGGAACAAGGAAACTACGCGGTGGATATTCGT
GCTACTACACACGACGAAGTAGGAGTTCTAACAAATTCGTTTTTAAGAATGGCGAGGGGATTGGAAGAAAGAGAAAAAAT
TAAAAATACATTCGGAAAGTTTGTGAATAAAGAGATCGCCGAACGCGCGTTATCTTCCGATTTAAAGTTGGGCGGAGAAA
ATAGGGAGGTCACGGTATTTTTTTCTGACCTTAGAAATTTTACGGGAATGTCCGAAAAGATGAAACCGGAAGAGGTGGTT
GAATTCTTAAATCAATATTTCACCGAAATGGTGGAATGTATTTATCTGACTCAGGGAATTGTGGATAAATTTATAGGTGA
CGCCGTGATGGCCCACTGGGGAGCTTTGGTTTACGATGGAAATGAAGCTAAAAATTCGATTAACGCCGCTTTGTTGATGA
GAAGAGCGTTGATAGAGTTTAATTTAAAAGGAAAAGAAATCGGTCGTCCTTTTACTCGTTTCGGTTGTGGGATCAATTCT
GGACCGGTGATCGTTGGGCAGATCGGCTCTGAAAAGAAGTTAGAATTTACGGTCATCGGAGATACGGTCAATCTTGCTTC
TAGAATTGAATATTTAAATAAGGAATTCGGTACGGACATCTTAATTTCAGAAAGTACGTATCAACAAGCAAAGGATCATT
TTAATTTTGTGGAGCTCCCACCCGTTTGGATTCGAGGTAAGGAAAAACCACAAGTCGTCTATGCAGTGTTAGGTTGGAAA
GACGATCAGGATTGTCCTAAGTCCTTGGAAGAATTACGAACGTTATGCGGAATTCCGGATCCTGAAAACCCTTCTCGGTC
TTTGGCATGA

Upstream 100 bases:

>100_bases
TGATTTCATTTTGATGTAAGGTTTAAGGATTTCAAGTCTATATCGTGTCTATTTCGTTCAAATTCTTCCCTAGGTCTTCA
TTCAAATTTTAGATTTTAGA

Downstream 100 bases:

>100_bases
ATTTATATTCTAAATTCAACAAGGAGATTTTTGTAGGAATTTTGTCTCTGCTTGTTTTAGGAGCTTCTTTGTTTCTTTTT
TGGAAAGAAGGAGCCGTGGA

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MTEDKTFLFCSRLKEGGMLDRWKDKNDKSVRWEELPNLHSDLQDLDLIIRSLISEKLSLGIREIIFCLSAEQALSLKKSR
DFLKLIKDLKRAGFTISSADKDKILSTNVESSSKFFRYLENRSRNVNCLVWTEDLALSQIESKYYDFLNHFHGYKFESFR
PSRFTIRVKLLSIVSAIITLSMGLMITMATYFFRKYSEILIQEYNLSLARMTGIQLSGQLKETTRKIQDFRSEDSEKFFR
TNSNAVAYVRFKNKTVNSALEIDSLFWNSKFLKSNSVVPDPTNLKNALEKSFSRLSGTLEILNVSNEFGFPAVAVLLPVG
VEISGLVFSASEFLGSFLSVRQTDFFQMIVVDSSGNLIAHSNDKEAVSGKDYKKHPLVENMLRSPSDNGSQRFDFEGREV
LGSYQQLEVGGLGIISTLDADIAFEAVYKIRRQNFWIMISVLSVAFFVVFVFSRTLTIPIIQLLSATKKVEQGNYAVDIR
ATTHDEVGVLTNSFLRMARGLEEREKIKNTFGKFVNKEIAERALSSDLKLGGENREVTVFFSDLRNFTGMSEKMKPEEVV
EFLNQYFTEMVECIYLTQGIVDKFIGDAVMAHWGALVYDGNEAKNSINAALLMRRALIEFNLKGKEIGRPFTRFGCGINS
GPVIVGQIGSEKKLEFTVIGDTVNLASRIEYLNKEFGTDILISESTYQQAKDHFNFVELPPVWIRGKEKPQVVYAVLGWK
DDQDCPKSLEELRTLCGIPDPENPSRSLA

Sequences:

>Translated_749_residues
MTEDKTFLFCSRLKEGGMLDRWKDKNDKSVRWEELPNLHSDLQDLDLIIRSLISEKLSLGIREIIFCLSAEQALSLKKSR
DFLKLIKDLKRAGFTISSADKDKILSTNVESSSKFFRYLENRSRNVNCLVWTEDLALSQIESKYYDFLNHFHGYKFESFR
PSRFTIRVKLLSIVSAIITLSMGLMITMATYFFRKYSEILIQEYNLSLARMTGIQLSGQLKETTRKIQDFRSEDSEKFFR
TNSNAVAYVRFKNKTVNSALEIDSLFWNSKFLKSNSVVPDPTNLKNALEKSFSRLSGTLEILNVSNEFGFPAVAVLLPVG
VEISGLVFSASEFLGSFLSVRQTDFFQMIVVDSSGNLIAHSNDKEAVSGKDYKKHPLVENMLRSPSDNGSQRFDFEGREV
LGSYQQLEVGGLGIISTLDADIAFEAVYKIRRQNFWIMISVLSVAFFVVFVFSRTLTIPIIQLLSATKKVEQGNYAVDIR
ATTHDEVGVLTNSFLRMARGLEEREKIKNTFGKFVNKEIAERALSSDLKLGGENREVTVFFSDLRNFTGMSEKMKPEEVV
EFLNQYFTEMVECIYLTQGIVDKFIGDAVMAHWGALVYDGNEAKNSINAALLMRRALIEFNLKGKEIGRPFTRFGCGINS
GPVIVGQIGSEKKLEFTVIGDTVNLASRIEYLNKEFGTDILISESTYQQAKDHFNFVELPPVWIRGKEKPQVVYAVLGWK
DDQDCPKSLEELRTLCGIPDPENPSRSLA
>Mature_748_residues
TEDKTFLFCSRLKEGGMLDRWKDKNDKSVRWEELPNLHSDLQDLDLIIRSLISEKLSLGIREIIFCLSAEQALSLKKSRD
FLKLIKDLKRAGFTISSADKDKILSTNVESSSKFFRYLENRSRNVNCLVWTEDLALSQIESKYYDFLNHFHGYKFESFRP
SRFTIRVKLLSIVSAIITLSMGLMITMATYFFRKYSEILIQEYNLSLARMTGIQLSGQLKETTRKIQDFRSEDSEKFFRT
NSNAVAYVRFKNKTVNSALEIDSLFWNSKFLKSNSVVPDPTNLKNALEKSFSRLSGTLEILNVSNEFGFPAVAVLLPVGV
EISGLVFSASEFLGSFLSVRQTDFFQMIVVDSSGNLIAHSNDKEAVSGKDYKKHPLVENMLRSPSDNGSQRFDFEGREVL
GSYQQLEVGGLGIISTLDADIAFEAVYKIRRQNFWIMISVLSVAFFVVFVFSRTLTIPIIQLLSATKKVEQGNYAVDIRA
TTHDEVGVLTNSFLRMARGLEEREKIKNTFGKFVNKEIAERALSSDLKLGGENREVTVFFSDLRNFTGMSEKMKPEEVVE
FLNQYFTEMVECIYLTQGIVDKFIGDAVMAHWGALVYDGNEAKNSINAALLMRRALIEFNLKGKEIGRPFTRFGCGINSG
PVIVGQIGSEKKLEFTVIGDTVNLASRIEYLNKEFGTDILISESTYQQAKDHFNFVELPPVWIRGKEKPQVVYAVLGWKD
DQDCPKSLEELRTLCGIPDPENPSRSLA

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17534665, Length=167, Percent_Identity=33.5329341317365, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212645647, Length=178, Percent_Identity=32.5842696629214, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=196, Percent_Identity=31.1224489795918, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=208, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24663839, Length=175, Percent_Identity=33.1428571428571, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24663843, Length=175, Percent_Identity=33.1428571428571, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI85725044, Length=205, Percent_Identity=30.2439024390244, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI62484298, Length=214, Percent_Identity=28.9719626168224, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484477, Length=214, Percent_Identity=28.9719626168224, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116008008, Length=214, Percent_Identity=28.9719626168224, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221330468, Length=169, Percent_Identity=30.1775147928994, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330470, Length=169, Percent_Identity=30.1775147928994, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076872, Length=208, Percent_Identity=30.2884615384615, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28574512, Length=208, Percent_Identity=30.2884615384615, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24647268, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 85026; Mature: 84894

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDKTFLFCSRLKEGGMLDRWKDKNDKSVRWEELPNLHSDLQDLDLIIRSLISEKLSLG
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
IREIIFCLSAEQALSLKKSRDFLKLIKDLKRAGFTISSADKDKILSTNVESSSKFFRYLE
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCHHHHHHHHHH
NRSRNVNCLVWTEDLALSQIESKYYDFLNHFHGYKFESFRPSRFTIRVKLLSIVSAIITL
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
SMGLMITMATYFFRKYSEILIQEYNLSLARMTGIQLSGQLKETTRKIQDFRSEDSEKFFR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCHHHHHHHHHHHHHCCCHHHHHH
TNSNAVAYVRFKNKTVNSALEIDSLFWNSKFLKSNSVVPDPTNLKNALEKSFSRLSGTLE
CCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
ILNVSNEFGFPAVAVLLPVGVEISGLVFSASEFLGSFLSVRQTDFFQMIVVDSSGNLIAH
EEEECCCCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
SNDKEAVSGKDYKKHPLVENMLRSPSDNGSQRFDFEGREVLGSYQQLEVGGLGIISTLDA
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHEEECCCEEHHHHCH
DIAFEAVYKIRRQNFWIMISVLSVAFFVVFVFSRTLTIPIIQLLSATKKVEQGNYAVDIR
HHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ATTHDEVGVLTNSFLRMARGLEEREKIKNTFGKFVNKEIAERALSSDLKLGGENREVTVF
ECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
FSDLRNFTGMSEKMKPEEVVEFLNQYFTEMVECIYLTQGIVDKFIGDAVMAHWGALVYDG
EHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
NEAKNSINAALLMRRALIEFNLKGKEIGRPFTRFGCGINSGPVIVGQIGSEKKLEFTVIG
CHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHCCCCCCCCEEEEECCCCCEEEEEEEC
DTVNLASRIEYLNKEFGTDILISESTYQQAKDHFNFVELPPVWIRGKEKPQVVYAVLGWK
CHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCEEECCCEEECCCCCCEEEEEEECCC
DDQDCPKSLEELRTLCGIPDPENPSRSLA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEDKTFLFCSRLKEGGMLDRWKDKNDKSVRWEELPNLHSDLQDLDLIIRSLISEKLSLG
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
IREIIFCLSAEQALSLKKSRDFLKLIKDLKRAGFTISSADKDKILSTNVESSSKFFRYLE
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCHHHHHHHHHH
NRSRNVNCLVWTEDLALSQIESKYYDFLNHFHGYKFESFRPSRFTIRVKLLSIVSAIITL
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
SMGLMITMATYFFRKYSEILIQEYNLSLARMTGIQLSGQLKETTRKIQDFRSEDSEKFFR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCHHHHHHHHHHHHHCCCHHHHHH
TNSNAVAYVRFKNKTVNSALEIDSLFWNSKFLKSNSVVPDPTNLKNALEKSFSRLSGTLE
CCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
ILNVSNEFGFPAVAVLLPVGVEISGLVFSASEFLGSFLSVRQTDFFQMIVVDSSGNLIAH
EEEECCCCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
SNDKEAVSGKDYKKHPLVENMLRSPSDNGSQRFDFEGREVLGSYQQLEVGGLGIISTLDA
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHEEECCCEEHHHHCH
DIAFEAVYKIRRQNFWIMISVLSVAFFVVFVFSRTLTIPIIQLLSATKKVEQGNYAVDIR
HHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ATTHDEVGVLTNSFLRMARGLEEREKIKNTFGKFVNKEIAERALSSDLKLGGENREVTVF
ECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
FSDLRNFTGMSEKMKPEEVVEFLNQYFTEMVECIYLTQGIVDKFIGDAVMAHWGALVYDG
EHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
NEAKNSINAALLMRRALIEFNLKGKEIGRPFTRFGCGINSGPVIVGQIGSEKKLEFTVIG
CHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHCCCCCCCCEEEEECCCCCEEEEEEEC
DTVNLASRIEYLNKEFGTDILISESTYQQAKDHFNFVELPPVWIRGKEKPQVVYAVLGWK
CHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCEEECCCEEECCCCCCEEEEEEECCC
DDQDCPKSLEELRTLCGIPDPENPSRSLA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]