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The map label for this gene is btuE

Identifier: 45658485

GI number: 45658485

Start: 3210464

End: 3211033

Strand: Reverse

Name: btuE

Synonym: LIC12648

Alternate gene names: 45658485

Gene position: 3211033-3210464 (Counterclockwise)

Preceding gene: 45658486

Following gene: 45658484

Centisome position: 75.07

GC content: 33.86

Gene sequence:

>570_bases
ATGAAAGAAGGAGCCAGTTTTATGTATTCAAAGTATTTCATTTGGTTTATGACTTTAGGAATTTTTTTACCATTAGCGGG
GATTTTTGCAAAGGGAAGTTTTTATGATTTCAAAGTAAAAGACATCAAAGGAAACGAAGTGTCTCTTTCTAAATATAAGG
GAAAGGTAGTGATGGTGGTGAACGTAGCTTCTAAATGTGGTTATACCTATCAATACGAACATCTCGAAAAAGTTTATAAA
AAATATAAGGATCAAGGATTTGCAGTAGTAGGTTTTCCCGCTAATAATTTTGGAGGCCAAGAACCAGGAACCGATCAAGA
AATCGAAACGTTTTGCAGAATTCAAAAAGGTGCAAGTTTTGATATGATGTCTAAAATTTCAGTCAAAGGAAAGGACATTC
ATCCTTTATATTTTTATCTGATTCAAAATTCTCCAAATCCGGGAGAAGTAGAATGGAACTTCGAAAAAATTTTAATATCA
AAAAGTGGAACAATAGAAGCGAGATACCGTTCTTCTGTTGAGCCTGATAGTTCCGCAGTGACTCAAAAAATTGAGACTCT
CTTAAAGTGA

Upstream 100 bases:

>100_bases
CTTACACCGAATTTACTTTATTTAACATAGAATAGATGACTTTCCTATAATTTCAGTTTAGAAAAACGATTGAAGTAAAT
AAAGGTTTGGATTTAAATTT

Downstream 100 bases:

>100_bases
CTGTATGCATTTGAAACATTCTTCTTTAATAGAACTTTTGAATTTAAAATCTCTATAAAATTCTAAACTATTAAAAACTT
CAAAATGAAAGTTTTGGAGT

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MKEGASFMYSKYFIWFMTLGIFLPLAGIFAKGSFYDFKVKDIKGNEVSLSKYKGKVVMVVNVASKCGYTYQYEHLEKVYK
KYKDQGFAVVGFPANNFGGQEPGTDQEIETFCRIQKGASFDMMSKISVKGKDIHPLYFYLIQNSPNPGEVEWNFEKILIS
KSGTIEARYRSSVEPDSSAVTQKIETLLK

Sequences:

>Translated_189_residues
MKEGASFMYSKYFIWFMTLGIFLPLAGIFAKGSFYDFKVKDIKGNEVSLSKYKGKVVMVVNVASKCGYTYQYEHLEKVYK
KYKDQGFAVVGFPANNFGGQEPGTDQEIETFCRIQKGASFDMMSKISVKGKDIHPLYFYLIQNSPNPGEVEWNFEKILIS
KSGTIEARYRSSVEPDSSAVTQKIETLLK
>Mature_189_residues
MKEGASFMYSKYFIWFMTLGIFLPLAGIFAKGSFYDFKVKDIKGNEVSLSKYKGKVVMVVNVASKCGYTYQYEHLEKVYK
KYKDQGFAVVGFPANNFGGQEPGTDQEIETFCRIQKGASFDMMSKISVKGKDIHPLYFYLIQNSPNPGEVEWNFEKILIS
KSGTIEARYRSSVEPDSSAVTQKIETLLK

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=162, Percent_Identity=42.5925925925926, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI75709200, Length=148, Percent_Identity=40.5405405405405, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI192455698, Length=159, Percent_Identity=37.7358490566038, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI90903240, Length=148, Percent_Identity=40.5405405405405, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI90903238, Length=129, Percent_Identity=40.3100775193798, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI4557629, Length=184, Percent_Identity=33.1521739130435, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=29.8913043478261, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI32967607, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI6006001, Length=167, Percent_Identity=31.1377245508982, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI33186887, Length=156, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1788003, Length=172, Percent_Identity=40.6976744186046, Blast_Score=140, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71993584, Length=147, Percent_Identity=40.8163265306122, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550320, Length=180, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=180, Percent_Identity=32.2222222222222, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506887, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193210707, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17535473, Length=147, Percent_Identity=35.3741496598639, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=42.1052631578947, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993573, Length=96, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=77, Percent_Identity=46.7532467532467, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319721, Length=161, Percent_Identity=45.9627329192547, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=47.7987421383648, Blast_Score=147, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322826, Length=145, Percent_Identity=36.551724137931, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656767, Length=181, Percent_Identity=39.7790055248619, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656772, Length=161, Percent_Identity=41.6149068322981, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=39.2405063291139, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656777, Length=161, Percent_Identity=41.6149068322981, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 21469; Mature: 21469

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGASFMYSKYFIWFMTLGIFLPLAGIFAKGSFYDFKVKDIKGNEVSLSKYKGKVVMVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEHEECCCEEEEEE
NVASKCGYTYQYEHLEKVYKKYKDQGFAVVGFPANNFGGQEPGTDQEIETFCRIQKGASF
EEHHHCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCC
DMMSKISVKGKDIHPLYFYLIQNSPNPGEVEWNFEKILISKSGTIEARYRSSVEPDSSAV
CHHHHEECCCCCCCEEEEEEEECCCCCCEEEEEHEEEEEECCCCEEEEECCCCCCCHHHH
TQKIETLLK
HHHHHHHHC
>Mature Secondary Structure
MKEGASFMYSKYFIWFMTLGIFLPLAGIFAKGSFYDFKVKDIKGNEVSLSKYKGKVVMVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEHEECCCEEEEEE
NVASKCGYTYQYEHLEKVYKKYKDQGFAVVGFPANNFGGQEPGTDQEIETFCRIQKGASF
EEHHHCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCC
DMMSKISVKGKDIHPLYFYLIQNSPNPGEVEWNFEKILISKSGTIEARYRSSVEPDSSAV
CHHHHEECCCCCCCEEEEEEEECCCCCCEEEEEHEEEEEECCCCEEEEECCCCCCCHHHH
TQKIETLLK
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]