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The map label for this gene is pdxH

Identifier: 45658362

GI number: 45658362

Start: 3049893

End: 3050537

Strand: Reverse

Name: pdxH

Synonym: LIC12520

Alternate gene names: 45658362

Gene position: 3050537-3049893 (Counterclockwise)

Preceding gene: 45658363

Following gene: 45658361

Centisome position: 71.32

GC content: 37.98

Gene sequence:

>645_bases
ATGGATCCTAAAATTTCAGAAATTAGAAAGAGTTATACACTATCTTCTTTAGAGATAGAAGACGCCGGAAGCGATCCGGT
TTTATTTTTTCAAAAATGGTTTGAGGAAGCCGTTCAGTCGGAAGTGTTGGAAGTCAATGCGATGACACTTGCAACTGTCA
CTCAAGATGGAAAACCAGACGCTAGAATCGTTCTATTAAAAGGAATTTTGAAGGAATCGTTTTTGTTTTATACCAATTAC
GAAAGTAGAAAAGGAACAGAATTAGAAACGAACCCAAACGTTTGTCTCGTTTTCTTTTGGCCTGAATTAGAACGTCAGGT
TCGTATCGAAGGAAACGTAACTAAAGTTTCTAGGGAAGTTTCTAAAGAATATTTTCATTCAAGGCCTAGAGAGTCTCAGA
TCGGTGCGTTAGCCTCACCGCAAAGTCAAAAAATTCCTGATCGTAAATTTTTAGAAGGACGTTTTCAGAAATTTACCAAT
CAATATCAAAATAAAGAAGTGGATCTTCCGAATCATTGGGGAGGTTATGCGGTTTACCCTTGTCGAATCGAATTTTGGCA
AGGTCGTTCCAGCCGTTTACACGATAGAATCGTGTTTGAAAGAGATACGTCTTCCTCTTGGGAAAAATTTAGAATTGCTC
CATGA

Upstream 100 bases:

>100_bases
TTTGAAAATAATGAATTCTGTGGGAACTACTTTCAGAGACTTTGTTTGAGAAATTTTCTTTTACTTACAAAATGACGTTT
ATTTTTTAAAATCAATTTCT

Downstream 100 bases:

>100_bases
CTATATTTAAATTTTAGAATATTCCTTTTGTTTGATTTTCCCTAACTACTCGTAGCTATAAAATTAAATACCGTGAAATT
TTATTGTAAAATACTGTTTG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MDPKISEIRKSYTLSSLEIEDAGSDPVLFFQKWFEEAVQSEVLEVNAMTLATVTQDGKPDARIVLLKGILKESFLFYTNY
ESRKGTELETNPNVCLVFFWPELERQVRIEGNVTKVSREVSKEYFHSRPRESQIGALASPQSQKIPDRKFLEGRFQKFTN
QYQNKEVDLPNHWGGYAVYPCRIEFWQGRSSRLHDRIVFERDTSSSWEKFRIAP

Sequences:

>Translated_214_residues
MDPKISEIRKSYTLSSLEIEDAGSDPVLFFQKWFEEAVQSEVLEVNAMTLATVTQDGKPDARIVLLKGILKESFLFYTNY
ESRKGTELETNPNVCLVFFWPELERQVRIEGNVTKVSREVSKEYFHSRPRESQIGALASPQSQKIPDRKFLEGRFQKFTN
QYQNKEVDLPNHWGGYAVYPCRIEFWQGRSSRLHDRIVFERDTSSSWEKFRIAP
>Mature_214_residues
MDPKISEIRKSYTLSSLEIEDAGSDPVLFFQKWFEEAVQSEVLEVNAMTLATVTQDGKPDARIVLLKGILKESFLFYTNY
ESRKGTELETNPNVCLVFFWPELERQVRIEGNVTKVSREVSKEYFHSRPRESQIGALASPQSQKIPDRKFLEGRFQKFTN
QYQNKEVDLPNHWGGYAVYPCRIEFWQGRSSRLHDRIVFERDTSSSWEKFRIAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=201, Percent_Identity=52.7363184079602, Blast_Score=211, Evalue=4e-55,
Organism=Escherichia coli, GI1787926, Length=211, Percent_Identity=42.654028436019, Blast_Score=184, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17553712, Length=220, Percent_Identity=43.1818181818182, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=43.0622009569378, Blast_Score=159, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45551845, Length=179, Percent_Identity=50.8379888268156, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24644901, Length=179, Percent_Identity=50.8379888268156, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=29.7619047619048, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640564, Length=212, Percent_Identity=23.5849056603774, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_LEPIC (Q72PF1)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002448.1
- ProteinModelPortal:   Q72PF1
- SMR:   Q72PF1
- GeneID:   2772265
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12520
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK573797
- BioCyc:   LINT267671:LIC_12520-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25010; Mature: 25010

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 62-62 BINDING 65-65 BINDING 67-67 BINDING 84-84 BINDING 124-124 BINDING 128-128 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPKISEIRKSYTLSSLEIEDAGSDPVLFFQKWFEEAVQSEVLEVNAMTLATVTQDGKPD
CCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
ARIVLLKGILKESFLFYTNYESRKGTELETNPNVCLVFFWPELERQVRIEGNVTKVSREV
CEEHHHHHHHHHHEEEEECCCCCCCCEEECCCCEEEEEECCCCCCEEEECCCHHHHHHHH
SKEYFHSRPRESQIGALASPQSQKIPDRKFLEGRFQKFTNQYQNKEVDLPNHWGGYAVYP
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
CRIEFWQGRSSRLHDRIVFERDTSSSWEKFRIAP
EEEEEECCCCCCCCCEEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MDPKISEIRKSYTLSSLEIEDAGSDPVLFFQKWFEEAVQSEVLEVNAMTLATVTQDGKPD
CCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
ARIVLLKGILKESFLFYTNYESRKGTELETNPNVCLVFFWPELERQVRIEGNVTKVSREV
CEEHHHHHHHHHHEEEEECCCCCCCCEEECCCCEEEEEECCCCCCEEEECCCHHHHHHHH
SKEYFHSRPRESQIGALASPQSQKIPDRKFLEGRFQKFTNQYQNKEVDLPNHWGGYAVYP
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
CRIEFWQGRSSRLHDRIVFERDTSSSWEKFRIAP
EEEEEECCCCCCCCCEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA