Definition Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession NC_005823
Length 4,277,185

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The map label for this gene is aroA

Identifier: 45658292

GI number: 45658292

Start: 2966892

End: 2968214

Strand: Reverse

Name: aroA

Synonym: LIC12449

Alternate gene names: 45658292

Gene position: 2968214-2966892 (Counterclockwise)

Preceding gene: 45658293

Following gene: 45658291

Centisome position: 69.4

GC content: 38.62

Gene sequence:

>1323_bases
ATGATTCCAAAAAAAACTAAACTCAAATCCAGGGAAATAGAAGTTCCGGGAGATAAATCACTTTCTCACCGTTCCGTTTT
GTTTGCGGCGCTTTCCAAAGGCAAATCCAAAGTAACCGGATTTTTAGAAGCAGAAGACCCTTTGAATACAATGTCCGCAT
TCGCCAAACTAGGATTAAAGGTCCAAAAGGTTAAACCGGGAGAATACGAATTTGAAAGTCCTGGAAAAAACAAACTTGTT
TCGCCTAATGTAGATTTGGATTTCGGAAACGCAGGAACTGGAATTCGATTGTCCGCAGGACTTATTTGTGGACTACCCGG
TATAAACGCTACTTTAACCGGAGACAATTCGCTTAAAAAACGTCCTATGGGAAGAATTATAAAACCCTTAAGTTCTATGG
GGGCTTCGATCGTAGGGCTTGGGGAAAAAGAAACCGCTCCTTTAAAAATCGAAGGAAAAAAATTAAAAGGATTTCGTTAT
GAAAGCCCGATTGCGAGCGCACAAGTCAAATCCTGTCTGATGCTGGCTGCGATTTCGTCTGAAACAGATTTGGAATATTC
GGAAAATATATTATCCAGAGATCATACCGAAAACATGTTTCGTTTTTTAGGAAACAAGATCGAACAAATTTCCCCTTTGC
ATTTTAAAATTAAACCTCCTTACGTTTTGAACGGTGGAGAATTTAGGGTGCCAGGAGATATTTCATCTGCGGCTTTTTTT
CTTGTGCTCGGAGTTTTGGCAAAAGAAGGAAATTTACTCATTAAAAACATAGGACTCAATCCGGCTCGGACGGGGATTTT
AACGGCGCTCCAATCGATGGGAGCAAAAATAGAAATCCAAAACAAACGTATAGAATGTGGTGAGCCTGTAGGGGATTTAA
AAACGTATCCTTCTAATTTAAAAAAATCAAATATTCCAGAATCTTTAATTCCTTCGATTATAGACGAAATACCAATCCTT
TCCGTTGCGGGTTTTTTTGCGGAAGGTGGTTTTGAAATTCGTCATGCGGAAGAACTCAGAGCCAAAGAATCGGATCGAAT
TCATACGATGGTTTCCAATTTTCGCGAACTCGGTATCGAAGTAGAAGAATATACGGACGGATATTCGTTTGATGGGACTT
CTAAAAAATCCTCGGAAGTATGGACTCGACTTTCCACTGTAAAAAAAATTCCAATTCAATCATATATGGATCATAGAATT
GCAATGAGTTTTTTGATTTTTAAAACGCTTTCCGGTTTAGATCTCCAAATTGACGAAACTTCTTGGATTGAGACTTCTTT
TCCTGGTTTTGAAAAGTTACTCGAGAGTTGTATCAATGAATGA

Upstream 100 bases:

>100_bases
TTAGAAAAATTGAATCCAAAAAATACTCTAGATCCGGAAGAATGGGAACGATTTATGGAAATTTCTCGTAGATCTAGAGA
TTTTATTTTGAAGAACCAGG

Downstream 100 bases:

>100_bases
AAACGTAATCGCTTTGGATGGTCCGGCGGGTTCTGGCAAAAGTACGGTAGCAAGACAAATCGCCGAAAAGATAGGATTTA
ATTATTTAGATACGGGCGCT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLKVQKVKPGEYEFESPGKNKLV
SPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKKRPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRY
ESPIASAQVKSCLMLAAISSETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFF
LVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGEPVGDLKTYPSNLKKSNIPESLIPSIIDEIPIL
SVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIEVEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRI
AMSFLIFKTLSGLDLQIDETSWIETSFPGFEKLLESCINE

Sequences:

>Translated_440_residues
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLKVQKVKPGEYEFESPGKNKLV
SPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKKRPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRY
ESPIASAQVKSCLMLAAISSETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFF
LVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGEPVGDLKTYPSNLKKSNIPESLIPSIIDEIPIL
SVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIEVEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRI
AMSFLIFKTLSGLDLQIDETSWIETSFPGFEKLLESCINE
>Mature_440_residues
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLKVQKVKPGEYEFESPGKNKLV
SPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKKRPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRY
ESPIASAQVKSCLMLAAISSETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFF
LVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGEPVGDLKTYPSNLKKSNIPESLIPSIIDEIPIL
SVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIEVEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRI
AMSFLIFKTLSGLDLQIDETSWIETSFPGFEKLLESCINE

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=434, Percent_Identity=28.8018433179723, Blast_Score=131, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=454, Percent_Identity=25.5506607929515, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_LEPIC (Q72PM1)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002378.1
- ProteinModelPortal:   Q72PM1
- SMR:   Q72PM1
- GeneID:   2769618
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12449
- NMPDR:   fig|267671.1.peg.2378
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- BioCyc:   LINT267671:LIC_12449-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 48262; Mature: 48262

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLK
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHHCCE
VQKVKPGEYEFESPGKNKLVSPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKK
EEECCCCCCCCCCCCCCCEECCCCCEECCCCCCCEEEECCEEECCCCCCEEECCCCHHHH
RPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRYESPIASAQVKSCLMLAAISS
CHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHCC
ETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFF
CCCCHHHHHHHHCCHHHHHHHHHCCHHHHCCCCEEEECCCEEECCCCEECCCCCHHHHHH
LVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGEPVGDLKTYPSNL
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCC
KKSNIPESLIPSIIDEIPILSVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIE
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
VEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRIAMSFLIFKTLSGLDLQIDET
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
SWIETSFPGFEKLLESCINE
CCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIPKKTKLKSREIEVPGDKSLSHRSVLFAALSKGKSKVTGFLEAEDPLNTMSAFAKLGLK
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHHCCE
VQKVKPGEYEFESPGKNKLVSPNVDLDFGNAGTGIRLSAGLICGLPGINATLTGDNSLKK
EEECCCCCCCCCCCCCCCEECCCCCEECCCCCCCEEEECCEEECCCCCCEEECCCCHHHH
RPMGRIIKPLSSMGASIVGLGEKETAPLKIEGKKLKGFRYESPIASAQVKSCLMLAAISS
CHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHCC
ETDLEYSENILSRDHTENMFRFLGNKIEQISPLHFKIKPPYVLNGGEFRVPGDISSAAFF
CCCCHHHHHHHHCCHHHHHHHHHCCHHHHCCCCEEEECCCEEECCCCEECCCCCHHHHHH
LVLGVLAKEGNLLIKNIGLNPARTGILTALQSMGAKIEIQNKRIECGEPVGDLKTYPSNL
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCC
KKSNIPESLIPSIIDEIPILSVAGFFAEGGFEIRHAEELRAKESDRIHTMVSNFRELGIE
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
VEEYTDGYSFDGTSKKSSEVWTRLSTVKKIPIQSYMDHRIAMSFLIFKTLSGLDLQIDET
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
SWIETSFPGFEKLLESCINE
CCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA